SEC61G — 3 ClinVar variants
All ClinVar germline SEC61G variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
3 Uncertain significance
Full SEC61G gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All SEC61G variants
Uncertain significance 3
- p.Arg12Gln Single submitter ⚠
- p.Gln34Arg Single submitter
- p.Phe49Leu Single submitter ⚠