SELE — 89 ClinVar variants
All ClinVar germline SELE variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
7 Benign · 6 Likely benign · 76 Uncertain significance
Full SELE gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SELE p.Glu277Lys Uncertain significance Multiple submitters
- SELE p.Ala249Ser Uncertain significance Single submitter
- SELE p.Ala369Thr Uncertain significance Single submitter
- SELE p.Ala432Gly Uncertain significance Single submitter
- SELE p.Ala497Val Uncertain significance Single submitter
- SELE p.Ala563Gly Uncertain significance Single submitter
- SELE p.Arg375Gln Uncertain significance Single submitter
- SELE p.Arg532Gln Uncertain significance Single submitter
- SELE p.Arg579Gln Uncertain significance Single submitter
- SELE p.Arg579Trp Uncertain significance Single submitter
- SELE p.Arg583Gln Uncertain significance Single submitter
- SELE p.Asn159Ser Uncertain significance Single submitter
- SELE p.Asn199Ser Uncertain significance Single submitter
- SELE p.Asp34His Uncertain significance Single submitter
- SELE p.Asp419Asn Uncertain significance Single submitter
- SELE p.Cys165Tyr Uncertain significance Single submitter
- SELE p.Cys174Tyr Uncertain significance Single submitter
- SELE p.Cys193Ser Uncertain significance Single submitter
- SELE p.Cys224Arg Uncertain significance Single submitter
- SELE p.Cys286Arg Uncertain significance Single submitter
- SELE p.Gln223Leu Uncertain significance Single submitter
- SELE p.Gln309Arg Uncertain significance Single submitter
- SELE p.Gln311Arg Uncertain significance Single submitter
- SELE p.Gln472Glu Uncertain significance Single submitter
- SELE p.Gln595Glu Uncertain significance Single submitter
- SELE p.Glu119Lys Uncertain significance Single submitter
- SELE p.Glu374Lys Uncertain significance Single submitter
- SELE p.Glu462Lys Uncertain significance Single submitter
- SELE p.Glu55Asp Uncertain significance Single submitter
- SELE p.Gly213Asp Uncertain significance Single submitter
- SELE p.Gly413Val Uncertain significance Single submitter
- SELE p.Gly464Arg Uncertain significance Single submitter
- SELE p.His188Arg Uncertain significance Single submitter
- SELE p.His46Tyr Uncertain significance Single submitter
- SELE p.Leu135Pro Uncertain significance Single submitter
- SELE p.Leu381Phe Uncertain significance Single submitter
- SELE p.Lys76Arg Uncertain significance Single submitter
- SELE p.Met279Thr Uncertain significance Single submitter
- SELE p.Met378Ile Uncertain significance Single submitter
- SELE p.Pro233Ser Uncertain significance Single submitter
- SELE p.Pro344Gln Uncertain significance Single submitter
- SELE p.Pro437Leu Uncertain significance Single submitter
- SELE p.Pro550Ser Uncertain significance Single submitter
- SELE p.Ser194Ile Uncertain significance Single submitter
- SELE p.Ser393Gly Uncertain significance Single submitter
- SELE p.Ser460Thr Uncertain significance Single submitter
- SELE p.Ser507Asn Uncertain significance Single submitter
- SELE p.Ser596Arg Uncertain significance Single submitter
- SELE p.Ser64Gly Uncertain significance Single submitter
- SELE p.Thr11Ala Uncertain significance Single submitter
- SELE p.Thr368Ala Uncertain significance Single submitter
- SELE p.Thr368Ile Uncertain significance Single submitter
- SELE p.Thr525Met Uncertain significance Single submitter
- SELE p.Val112Met Uncertain significance Single submitter
- SELE p.Val13Ala Uncertain significance Single submitter
-
SELE p.His468Tyr
Uncertain significance
No assertion criteria
IgA nephropathy, susceptibility to
Predictors split 15
The independent predictors disagree with each other — read with care.
- SELE p.Phe325Leu Uncertain significance Multiple submitters
- SELE p.Ala322Pro Uncertain significance Single submitter
- SELE p.Gln411Pro Uncertain significance Single submitter
- SELE p.Glu156Asp Uncertain significance Single submitter
- SELE p.Gly323Arg Uncertain significance Single submitter
- SELE p.Gly416Ala Uncertain significance Single submitter
- SELE p.Gly439Ser Uncertain significance Single submitter
- SELE p.Gly528Asp Uncertain significance Single submitter
- SELE p.Leu410Phe Uncertain significance Single submitter
- SELE p.Pro216Thr Uncertain significance Single submitter
- SELE p.Ser61Phe Uncertain significance Single submitter
- SELE p.Thr91Arg Uncertain significance Single submitter
- SELE p.Tyr453Cys Uncertain significance Single submitter
- SELE p.Val178Gly Uncertain significance Single submitter
- SELE p.Val48Ile Uncertain significance Single submitter
All SELE variants
Benign 7
- p.Asn291= Multiple submitters
- p.Asn420= Multiple submitters
- p.Glu295Lys Multiple submitters
- p.Glu421Gln Multiple submitters
- p.Leu575Phe Multiple submitters coronary artery disorder
- c.38-139T>C Single submitter coronary artery disorder
- p.Leu404= Single submitter
Likely benign 6
- p.Ile208= Single submitter
- p.Ile208Val Single submitter
- p.Lys296Thr Single submitter
- p.Lys438Asn Single submitter
- p.Met219Thr Single submitter
- p.Pro499Leu Single submitter
Uncertain significance 76
- p.Glu277Lys Multiple submitters ⚠
- p.Phe325Leu Multiple submitters ⚠
- c.901+9G>T Single submitter
- p.Ala249Ser Single submitter ⚠
- p.Ala322Pro Single submitter ⚠
- p.Ala369Thr Single submitter ⚠
- p.Ala432Gly Single submitter ⚠
- p.Ala497Val Single submitter ⚠
- p.Ala563Gly Single submitter ⚠
- p.Arg375Gln Single submitter ⚠
- p.Arg532Gln Single submitter ⚠
- p.Arg579Gln Single submitter ⚠
- p.Arg579Trp Single submitter ⚠
- p.Arg583Gln Single submitter ⚠
- p.Asn159Ser Single submitter ⚠
- p.Asn199Ser Single submitter ⚠
- p.Asp34His Single submitter ⚠
- p.Asp419Asn Single submitter ⚠
- p.Cys165Tyr Single submitter ⚠
- p.Cys174Tyr Single submitter ⚠
- p.Cys193Ser Single submitter ⚠
- p.Cys224Arg Single submitter ⚠
- p.Cys286Arg Single submitter ⚠
- p.Gln223Leu Single submitter ⚠
- p.Gln309Arg Single submitter ⚠
- p.Gln311Arg Single submitter ⚠
- p.Gln411Pro Single submitter ⚠
- p.Gln472Glu Single submitter ⚠
- p.Gln595Glu Single submitter ⚠
- p.Glu119Lys Single submitter ⚠
- p.Glu156Asp Single submitter ⚠
- p.Glu374Lys Single submitter ⚠
- p.Glu462Lys Single submitter ⚠
- p.Glu55Asp Single submitter ⚠
- p.Gly213Asp Single submitter ⚠
- p.Gly323Arg Single submitter ⚠
- p.Gly413Val Single submitter ⚠
- p.Gly416Ala Single submitter ⚠
- p.Gly439Ser Single submitter ⚠
- p.Gly464Arg Single submitter ⚠
- p.Gly528Asp Single submitter ⚠
- p.His188Arg Single submitter ⚠
- p.His46Tyr Single submitter ⚠
- p.Ile158Thr Single submitter
- p.Leu135Pro Single submitter ⚠
- p.Leu381Phe Single submitter ⚠
- p.Leu410Phe Single submitter ⚠
- p.Lys132Thr Single submitter
- p.Lys76Arg Single submitter ⚠
- p.Met279Thr Single submitter ⚠
- p.Met378Ile Single submitter ⚠
- p.Phe396Ile Single submitter
- p.Pro216Thr Single submitter ⚠
- p.Pro233Ser Single submitter ⚠
- p.Pro344Gln Single submitter ⚠
- p.Pro437Leu Single submitter ⚠
- p.Pro550Ser Single submitter ⚠
- p.Ser194Ile Single submitter ⚠
- p.Ser289Pro Single submitter
- p.Ser393Gly Single submitter ⚠
- p.Ser460Thr Single submitter ⚠
- p.Ser507Asn Single submitter ⚠
- p.Ser596Arg Single submitter ⚠
- p.Ser61Phe Single submitter ⚠
- p.Ser64Gly Single submitter ⚠
- p.Thr11Ala Single submitter ⚠
- p.Thr368Ala Single submitter ⚠
- p.Thr368Ile Single submitter ⚠
- p.Thr525Met Single submitter ⚠
- p.Thr91Arg Single submitter ⚠
- p.Tyr453Cys Single submitter ⚠
- p.Val112Met Single submitter ⚠
- p.Val13Ala Single submitter ⚠
- p.Val178Gly Single submitter ⚠
- p.Val48Ile Single submitter ⚠
- p.His468Tyr No assertion criteria IgA nephropathy, susceptibility to ⚠