SENP3 — 54 ClinVar variants
All ClinVar germline SENP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
1 Likely benign · 53 Uncertain significance
Full SENP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SENP3 p.Ala303Val Uncertain significance Single submitter
- SENP3 p.Ala382Ser Uncertain significance Single submitter
- SENP3 p.Ala74Thr Uncertain significance Single submitter
- SENP3 p.Arg101Gly Uncertain significance Single submitter
- SENP3 p.Arg157Gln Uncertain significance Single submitter
- SENP3 p.Arg210Gly Uncertain significance Single submitter
- SENP3 p.Arg310Gln Uncertain significance Single submitter
- SENP3 p.Arg31Cys Uncertain significance Single submitter
- SENP3 p.Arg380Gln Uncertain significance Single submitter
- SENP3 p.Asp187His Uncertain significance Single submitter
- SENP3 p.Asp207Gly Uncertain significance Single submitter
- SENP3 p.Asp88Asn Uncertain significance Single submitter
- SENP3 p.Gln252His Uncertain significance Single submitter
- SENP3 p.Glu222Gln Uncertain significance Single submitter
- SENP3 p.Glu222Val Uncertain significance Single submitter
- SENP3 p.Glu258Gln Uncertain significance Single submitter
- SENP3 p.Glu420Gly Uncertain significance Single submitter
- SENP3 p.Glu85Asp Uncertain significance Single submitter
- SENP3 p.Glu92Lys Uncertain significance Single submitter
- SENP3 p.Gly211Ala Uncertain significance Single submitter
- SENP3 p.Gly239Asp Uncertain significance Single submitter
- SENP3 p.Gly304Ser Uncertain significance Single submitter
- SENP3 p.Gly9Trp Uncertain significance Single submitter
- SENP3 p.His118Gln Uncertain significance Single submitter
- SENP3 p.His306Arg Uncertain significance Single submitter
- SENP3 p.His386Tyr Uncertain significance Single submitter
- SENP3 p.Ile320Val Uncertain significance Single submitter
- SENP3 p.Leu137Phe Uncertain significance Single submitter
- SENP3 p.Leu161Phe Uncertain significance Single submitter
- SENP3 p.Leu203Phe Uncertain significance Single submitter
- SENP3 p.Leu240Phe Uncertain significance Single submitter
- SENP3 p.Leu245Val Uncertain significance Single submitter
- SENP3 p.Lys231Glu Uncertain significance Single submitter
- SENP3 p.Phe186Leu Uncertain significance Single submitter
- SENP3 p.Pro180Ser Uncertain significance Single submitter
- SENP3 p.Pro219Ser Uncertain significance Single submitter
- SENP3 p.Pro22Arg Uncertain significance Single submitter
- SENP3 p.Pro233Ala Uncertain significance Single submitter
- SENP3 p.Pro263Leu Uncertain significance Single submitter
- SENP3 p.Pro263Thr Uncertain significance Single submitter
- SENP3 p.Pro27Ala Uncertain significance Single submitter
- SENP3 p.Pro557His Uncertain significance Single submitter
- SENP3 p.Pro66His Uncertain significance Single submitter
- SENP3 p.Ser238Ala Uncertain significance Single submitter
- SENP3 p.Thr229Ile Uncertain significance Single submitter
- SENP3 p.Thr327Arg Uncertain significance Single submitter
-
SENP3 p.Trp515Leu
Uncertain significance
No assertion criteria
myoepithelial tumor
Predictors split 6
The independent predictors disagree with each other — read with care.
- SENP3 p.Arg134Trp Uncertain significance Single submitter
- SENP3 p.Asp224Tyr Uncertain significance Single submitter
- SENP3 p.Glu77Lys Uncertain significance Single submitter
- SENP3 p.Gly248Arg Uncertain significance Single submitter
- SENP3 p.Val273Ala Uncertain significance Single submitter
- SENP3 p.Val317Leu Uncertain significance Single submitter
All SENP3 variants
Likely benign 1
- p.Ile276= Single submitter
Uncertain significance 53
- p.Ala303Val Single submitter ⚠
- p.Ala382Ser Single submitter ⚠
- p.Ala74Thr Single submitter ⚠
- p.Arg101Gly Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg157Gln Single submitter ⚠
- p.Arg210Gly Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg380Gln Single submitter ⚠
- p.Asp187His Single submitter ⚠
- p.Asp207Gly Single submitter ⚠
- p.Asp224Tyr Single submitter ⚠
- p.Asp88Asn Single submitter ⚠
- p.Gln252His Single submitter ⚠
- p.Glu222Gln Single submitter ⚠
- p.Glu222Val Single submitter ⚠
- p.Glu258Gln Single submitter ⚠
- p.Glu420Gly Single submitter ⚠
- p.Glu77Lys Single submitter ⚠
- p.Glu85Asp Single submitter ⚠
- p.Glu92Lys Single submitter ⚠
- p.Gly211Ala Single submitter ⚠
- p.Gly239Asp Single submitter ⚠
- p.Gly248Arg Single submitter ⚠
- p.Gly304Ser Single submitter ⚠
- p.Gly9Trp Single submitter ⚠
- p.His118Gln Single submitter ⚠
- p.His306Arg Single submitter ⚠
- p.His386Tyr Single submitter ⚠
- p.Ile320Val Single submitter ⚠
- p.Leu137Phe Single submitter ⚠
- p.Leu161Phe Single submitter ⚠
- p.Leu203Phe Single submitter ⚠
- p.Leu240Phe Single submitter ⚠
- p.Leu245Val Single submitter ⚠
- p.Lys231Glu Single submitter ⚠
- p.Phe186Leu Single submitter ⚠
- p.Pro180Ser Single submitter ⚠
- p.Pro219Ser Single submitter ⚠
- p.Pro22Arg Single submitter ⚠
- p.Pro233Ala Single submitter ⚠
- p.Pro263Leu Single submitter ⚠
- p.Pro263Thr Single submitter ⚠
- p.Pro27Ala Single submitter ⚠
- p.Pro557His Single submitter ⚠
- p.Pro66His Single submitter ⚠
- p.Ser238Ala Single submitter ⚠
- p.Thr229Ile Single submitter ⚠
- p.Thr327Arg Single submitter ⚠
- p.Val273Ala Single submitter ⚠
- p.Val317Leu Single submitter ⚠
- p.Trp515Leu No assertion criteria myoepithelial tumor ⚠