SENP8 — 15 ClinVar variants
All ClinVar germline SENP8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
15 Uncertain significance
Full SENP8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SENP8 p.Ala35Val Uncertain significance Single submitter
- SENP8 p.Ala98Ser Uncertain significance Single submitter
- SENP8 p.Asp204Ala Uncertain significance Single submitter
- SENP8 p.Met73Leu Uncertain significance Single submitter
- SENP8 p.Pro3Ala Uncertain significance Single submitter
- SENP8 p.Ser114Asn Uncertain significance Single submitter
- SENP8 p.Val150Met Uncertain significance Single submitter
- SENP8 p.Val51Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All SENP8 variants
Uncertain significance 15
- p.Ala35Val Single submitter ⚠
- p.Ala98Ser Single submitter ⚠
- p.Arg14Trp Single submitter
- p.Asp204Ala Single submitter ⚠
- p.Met73Leu Single submitter ⚠
- p.Phe139Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro3Ala Single submitter ⚠
- p.Ser114Asn Single submitter ⚠
- p.Ser16Leu Single submitter
- p.Ser94Tyr Single submitter ⚠
- p.Thr191Pro Single submitter ⚠
- p.Val150Met Single submitter ⚠
- p.Val51Ile Single submitter ⚠
- p.Trp202Ter No assertion criteria Neurodevelopmental abnormality