SERPINB10 — 58 ClinVar variants
All ClinVar germline SERPINB10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
4 Likely benign · 54 Uncertain significance
Full SERPINB10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SERPINB10 p.Ala113Val Uncertain significance Single submitter
- SERPINB10 p.Ala12Ser Uncertain significance Single submitter
- SERPINB10 p.Ala320Val Uncertain significance Single submitter
- SERPINB10 p.Ala351Val Uncertain significance Single submitter
- SERPINB10 p.Arg246His Uncertain significance Single submitter
- SERPINB10 p.Arg364Ile Uncertain significance Single submitter
- SERPINB10 p.Asn330Ser Uncertain significance Single submitter
- SERPINB10 p.Asn335Ser Uncertain significance Single submitter
- SERPINB10 p.Asn345Ser Uncertain significance Single submitter
- SERPINB10 p.Asn371Ser Uncertain significance Single submitter
- SERPINB10 p.Asn84Ser Uncertain significance Single submitter
- SERPINB10 p.Asp172Val Uncertain significance Single submitter
- SERPINB10 p.Gln161Glu Uncertain significance Single submitter
- SERPINB10 p.Gln288His Uncertain significance Single submitter
- SERPINB10 p.Glu137Asp Uncertain significance Single submitter
- SERPINB10 p.Glu358Asp Uncertain significance Single submitter
- SERPINB10 p.Gly354Ser Uncertain significance Single submitter
- SERPINB10 p.His195Gln Uncertain significance Single submitter
- SERPINB10 p.Ile154Val Uncertain significance Single submitter
- SERPINB10 p.Ile192Met Uncertain significance Single submitter
- SERPINB10 p.Ile359Thr Uncertain significance Single submitter
- SERPINB10 p.Ile88Val Uncertain significance Single submitter
- SERPINB10 p.Phe294Ser Uncertain significance Single submitter
- SERPINB10 p.Pro216Gln Uncertain significance Single submitter
- SERPINB10 p.Pro216Ser Uncertain significance Single submitter
- SERPINB10 p.Pro366Leu Uncertain significance Single submitter
- SERPINB10 p.Pro366Ser Uncertain significance Single submitter
- SERPINB10 p.Pro70Thr Uncertain significance Single submitter
- SERPINB10 p.Ser278Arg Uncertain significance Single submitter
- SERPINB10 p.Ser308Asn Uncertain significance Single submitter
- SERPINB10 p.Ser31Phe Uncertain significance Single submitter
- SERPINB10 p.Ser326Phe Uncertain significance Single submitter
- SERPINB10 p.Ser326Pro Uncertain significance Single submitter
- SERPINB10 p.Ser367Phe Uncertain significance Single submitter
- SERPINB10 p.Ser85Leu Uncertain significance Single submitter
- SERPINB10 p.Thr203Ala Uncertain significance Single submitter
- SERPINB10 p.Trp193Arg Uncertain significance Single submitter
- SERPINB10 p.Tyr115His Uncertain significance Single submitter
- SERPINB10 p.Val141Ile Uncertain significance Single submitter
- SERPINB10 p.Val184Gly Uncertain significance Single submitter
- SERPINB10 p.Val336Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- SERPINB10 p.Ala12Val Uncertain significance Single submitter
- SERPINB10 p.Ala186Thr Uncertain significance Single submitter
- SERPINB10 p.Ala314Thr Uncertain significance Single submitter
- SERPINB10 p.Gly48Ser Uncertain significance Single submitter
- SERPINB10 p.Leu39Phe Uncertain significance Single submitter
- SERPINB10 p.Lys339Arg Uncertain significance Single submitter
- SERPINB10 p.Met181Ile Uncertain significance Single submitter
- SERPINB10 p.Met54Leu Uncertain significance Single submitter
- SERPINB10 p.Phe378Leu Uncertain significance Single submitter
- SERPINB10 p.Ser396Cys Uncertain significance Single submitter
- SERPINB10 p.Thr179Ala Uncertain significance Single submitter
All SERPINB10 variants
Likely benign 4
- p.Glu211Lys Single submitter
- p.Leu394Phe Single submitter
- p.Ser245Asn Single submitter
- p.Ser32Pro Single submitter
Uncertain significance 54
- p.Ala113Val Single submitter ⚠
- p.Ala12Ser Single submitter ⚠
- p.Ala12Val Single submitter ⚠
- p.Ala186Thr Single submitter ⚠
- p.Ala314Thr Single submitter ⚠
- p.Ala320Val Single submitter ⚠
- p.Ala351Val Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg364Ile Single submitter ⚠
- p.Asn330Ser Single submitter ⚠
- p.Asn335Ser Single submitter ⚠
- p.Asn345Ser Single submitter ⚠
- p.Asn371Ser Single submitter ⚠
- p.Asn84Ser Single submitter ⚠
- p.Asp172Val Single submitter ⚠
- p.Gln161Glu Single submitter ⚠
- p.Gln288His Single submitter ⚠
- p.Glu137Asp Single submitter ⚠
- p.Glu358Asp Single submitter ⚠
- p.Gly354Ser Single submitter ⚠
- p.Gly48Ala Single submitter
- p.Gly48Ser Single submitter ⚠
- p.His195Gln Single submitter ⚠
- p.Ile154Val Single submitter ⚠
- p.Ile192Met Single submitter ⚠
- p.Ile359Thr Single submitter ⚠
- p.Ile88Val Single submitter ⚠
- p.Leu39Phe Single submitter ⚠
- p.Lys339Arg Single submitter ⚠
- p.Met181Ile Single submitter ⚠
- p.Met54Leu Single submitter ⚠
- p.Phe294Ser Single submitter ⚠
- p.Phe378Leu Single submitter ⚠
- p.Pro216Gln Single submitter ⚠
- p.Pro216Ser Single submitter ⚠
- p.Pro366Leu Single submitter ⚠
- p.Pro366Ser Single submitter ⚠
- p.Pro70Thr Single submitter ⚠
- p.Ser278Arg Single submitter ⚠
- p.Ser308Asn Single submitter ⚠
- p.Ser31Phe Single submitter ⚠
- p.Ser326Phe Single submitter ⚠
- p.Ser326Pro Single submitter ⚠
- p.Ser367Phe Single submitter ⚠
- p.Ser396Cys Single submitter ⚠
- p.Ser85Leu Single submitter ⚠
- p.Thr179Ala Single submitter ⚠
- p.Thr203Ala Single submitter ⚠
- p.Trp193Arg Single submitter ⚠
- p.Tyr115His Single submitter ⚠
- p.Val141Ile Single submitter ⚠
- p.Val184Gly Single submitter ⚠
- p.Val336Ile Single submitter ⚠
- p.Val57Met Single submitter