SGK1 — 33 ClinVar variants
All ClinVar germline SGK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely pathogenic · 1 Benign · 4 Likely benign · 27 Uncertain significance
Full SGK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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SGK1 p.Asn460Ser
Likely pathogenic
No assertion criteria
plasma cell myeloma
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SGK1 p.Ala519Val Uncertain significance Single submitter
- SGK1 p.Arg293Trp Uncertain significance Single submitter
- SGK1 p.Arg295His Uncertain significance Single submitter
- SGK1 p.Arg395Gly Uncertain significance Single submitter
- SGK1 p.Asp326Glu Uncertain significance Single submitter
- SGK1 p.Glu483Lys Uncertain significance Single submitter
- SGK1 p.Glu486Lys Uncertain significance Single submitter
- SGK1 p.Glu487Gln Uncertain significance Single submitter
- SGK1 p.Gly425Asp Uncertain significance Single submitter
- SGK1 p.Gly436Arg Uncertain significance Single submitter
- SGK1 p.His212Gln Uncertain significance Single submitter
- SGK1 p.His365Tyr Uncertain significance Single submitter
- SGK1 p.Ile152Val Uncertain significance Single submitter
- SGK1 p.Ile343Val Uncertain significance Single submitter
- SGK1 p.Lys233Arg Uncertain significance Single submitter
- SGK1 p.Phe253Leu Uncertain significance Single submitter
- SGK1 p.Pro186Leu Uncertain significance Single submitter
- SGK1 p.Tyr281Phe Uncertain significance Single submitter
- SGK1 p.Tyr297Cys Uncertain significance Single submitter
- SGK1 p.Tyr383Cys Uncertain significance Single submitter
- SGK1 p.Val506Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All SGK1 variants
Likely pathogenic 1
- p.Asn460Ser No assertion criteria plasma cell myeloma ⚠
Benign 1
- p.Ala510= Single submitter
Likely benign 4
- c.362-10T>C Single submitter
- p.Asn83Lys Single submitter
- p.Val500Ile Single submitter
- p.Val502Ile Single submitter
Uncertain significance 27
- p.Ala519Val Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg295His Single submitter ⚠
- p.Arg395Gln Single submitter ⚠
- p.Arg395Gly Single submitter ⚠
- p.Asp326Glu Single submitter ⚠
- p.Cys288Trp Single submitter ⚠
- p.Glu483Lys Single submitter ⚠
- p.Glu486Lys Single submitter ⚠
- p.Glu487Gln Single submitter ⚠
- p.Gly425Asp Single submitter ⚠
- p.Gly436Arg Single submitter ⚠
- p.His212Gln Single submitter ⚠
- p.His258Tyr Single submitter
- p.His365Tyr Single submitter ⚠
- p.Ile152Val Single submitter ⚠
- p.Ile343Val Single submitter ⚠
- p.Lys233Arg Single submitter ⚠
- p.Phe253Leu Single submitter ⚠
- p.Pro182Leu Single submitter
- p.Pro186Leu Single submitter ⚠
- p.Tyr281Phe Single submitter ⚠
- p.Tyr297Cys Single submitter ⚠
- p.Tyr383Cys Single submitter ⚠
- p.Tyr387His Single submitter ⚠
- p.Val363Met Single submitter ⚠
- p.Val506Ile Single submitter ⚠