SIRT4 — 49 ClinVar variants
All ClinVar germline SIRT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
2 Benign · 3 Likely benign · 44 Uncertain significance
Full SIRT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SIRT4 p.Ala107Val Uncertain significance Single submitter
- SIRT4 p.Ala18Thr Uncertain significance Single submitter
- SIRT4 p.Arg102His Uncertain significance Single submitter
- SIRT4 p.Arg156His Uncertain significance Single submitter
- SIRT4 p.Asp230Glu Uncertain significance Single submitter
- SIRT4 p.Cys172Gly Uncertain significance Single submitter
- SIRT4 p.Gln175Pro Uncertain significance Single submitter
- SIRT4 p.Gln211His Uncertain significance Single submitter
- SIRT4 p.Glu132Lys Uncertain significance Single submitter
- SIRT4 p.Glu252Ala Uncertain significance Single submitter
- SIRT4 p.Gly153Trp Uncertain significance Single submitter
- SIRT4 p.Gly288Ala Uncertain significance Single submitter
- SIRT4 p.Leu207Val Uncertain significance Single submitter
- SIRT4 p.Lys248Glu Uncertain significance Single submitter
- SIRT4 p.Lys279Gln Uncertain significance Single submitter
- SIRT4 p.Met164Thr Uncertain significance Single submitter
- SIRT4 p.Pro23Leu Uncertain significance Single submitter
- SIRT4 p.Pro72Leu Uncertain significance Single submitter
- SIRT4 p.Ser154Asn Uncertain significance Single submitter
- SIRT4 p.Ser21Arg Uncertain significance Single submitter
- SIRT4 p.Ser69Leu Uncertain significance Single submitter
- SIRT4 p.Thr219Asn Uncertain significance Single submitter
- SIRT4 p.Tyr269Ser Uncertain significance Single submitter
- SIRT4 p.Val111Ile Uncertain significance Single submitter
- SIRT4 p.Val232Ile Uncertain significance Single submitter
- SIRT4 p.Val259Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- SIRT4 p.Arg102Cys Benign Multiple submitters
- SIRT4 p.Arg184Cys Uncertain significance Single submitter
- SIRT4 p.Arg303Cys Uncertain significance Single submitter
- SIRT4 p.Arg303His Uncertain significance Single submitter
- SIRT4 p.Arg49Pro Uncertain significance Single submitter
- SIRT4 p.Arg84Leu Uncertain significance Single submitter
- SIRT4 p.Arg97Trp Uncertain significance Single submitter
- SIRT4 p.Asp254Asn Uncertain significance Single submitter
- SIRT4 p.Gly135Arg Uncertain significance Single submitter
- SIRT4 p.Ile282Thr Uncertain significance Single submitter
- SIRT4 p.Leu128Phe Uncertain significance Single submitter
- SIRT4 p.Met164Lys Uncertain significance Single submitter
- SIRT4 p.Phe116Leu Uncertain significance Single submitter
- SIRT4 p.Phe245Leu Uncertain significance Single submitter
- SIRT4 p.Tyr269Cys Uncertain significance Single submitter
- SIRT4 p.Val243Ala Uncertain significance Single submitter
All SIRT4 variants
Benign 2
- p.Arg102Cys Multiple submitters ⚠
- p.Ile284= Multiple submitters
Likely benign 3
- p.Arg155Gln Single submitter
- p.Ile29Thr Single submitter
- p.Val205Ile Single submitter
Uncertain significance 44
- p.Ala107Val Single submitter ⚠
- p.Ala152Val Single submitter
- p.Ala18Thr Single submitter ⚠
- p.Arg102His Single submitter ⚠
- p.Arg156His Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg291Trp Single submitter
- p.Arg303Cys Single submitter ⚠
- p.Arg303His Single submitter ⚠
- p.Arg49Pro Single submitter ⚠
- p.Arg84Leu Single submitter ⚠
- p.Arg97Trp Single submitter ⚠
- p.Asp230Glu Single submitter ⚠
- p.Asp254Asn Single submitter ⚠
- p.Cys172Gly Single submitter ⚠
- p.Gln175Pro Single submitter ⚠
- p.Gln211His Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Glu252Ala Single submitter ⚠
- p.Gly135Arg Single submitter ⚠
- p.Gly153Trp Single submitter ⚠
- p.Gly288Ala Single submitter ⚠
- p.Ile282Thr Single submitter ⚠
- p.Leu128Phe Single submitter ⚠
- p.Leu207Val Single submitter ⚠
- p.Lys248Glu Single submitter ⚠
- p.Lys279Gln Single submitter ⚠
- p.Met164Lys Single submitter ⚠
- p.Met164Thr Single submitter ⚠
- p.Phe116Leu Single submitter ⚠
- p.Phe245Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Ser154Asn Single submitter ⚠
- p.Ser21Arg Single submitter ⚠
- p.Ser69Leu Single submitter ⚠
- p.Thr219Asn Single submitter ⚠
- p.Tyr269Cys Single submitter ⚠
- p.Tyr269Ser Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val232Ile Single submitter ⚠
- p.Val243Ala Single submitter ⚠
- p.Val258Ala Single submitter
- p.Val259Met Single submitter ⚠