SIRT5 — 55 ClinVar variants
All ClinVar germline SIRT5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
5 Likely benign · 50 Uncertain significance
Full SIRT5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SIRT5 p.Ala116Thr Uncertain significance Single submitter
- SIRT5 p.Ala149Thr Uncertain significance Single submitter
- SIRT5 p.Ala173Thr Uncertain significance Single submitter
- SIRT5 p.Ala230Thr Uncertain significance Single submitter
- SIRT5 p.Ala230Val Uncertain significance Single submitter
- SIRT5 p.Ala240Thr Uncertain significance Single submitter
- SIRT5 p.Arg105Gln Uncertain significance Single submitter
- SIRT5 p.Arg105Trp Uncertain significance Single submitter
- SIRT5 p.Arg106Pro Uncertain significance Single submitter
- SIRT5 p.Arg106Trp Uncertain significance Single submitter
- SIRT5 p.Arg119His Uncertain significance Single submitter
- SIRT5 p.Arg147His Uncertain significance Single submitter
- SIRT5 p.Arg147Ser Uncertain significance Single submitter
- SIRT5 p.Arg217Gln Uncertain significance Single submitter
- SIRT5 p.Asp143Asn Uncertain significance Single submitter
- SIRT5 p.Cys30Phe Uncertain significance Single submitter
- SIRT5 p.Gln28Arg Uncertain significance Single submitter
- SIRT5 p.Gln5Arg Uncertain significance Single submitter
- SIRT5 p.Glu123Asp Uncertain significance Single submitter
- SIRT5 p.Glu123Gln Uncertain significance Single submitter
- SIRT5 p.Glu208Lys Uncertain significance Single submitter
- SIRT5 p.Glu209Lys Uncertain significance Single submitter
- SIRT5 p.Gly117Arg Uncertain significance Single submitter
- SIRT5 p.Gly193Val Uncertain significance Single submitter
- SIRT5 p.Gly213Arg Uncertain significance Single submitter
- SIRT5 p.Leu128Val Uncertain significance Single submitter
- SIRT5 p.Leu301Pro Uncertain significance Single submitter
- SIRT5 p.Lys177Arg Uncertain significance Single submitter
- SIRT5 p.Phe101Leu Uncertain significance Single submitter
- SIRT5 p.Pro218Arg Uncertain significance Single submitter
- SIRT5 p.Pro21Leu Uncertain significance Single submitter
- SIRT5 p.Pro229Ser Uncertain significance Single submitter
- SIRT5 p.Pro68Leu Uncertain significance Single submitter
- SIRT5 p.Pro68Ser Uncertain significance Single submitter
- SIRT5 p.Ser96Phe Uncertain significance Single submitter
- SIRT5 p.Thr250Ala Uncertain significance Single submitter
- SIRT5 p.Thr295Arg Uncertain significance Single submitter
- SIRT5 p.Tyr102Cys Uncertain significance Single submitter
- SIRT5 p.Val171Ile Uncertain significance Single submitter
- SIRT5 p.Val221Met Uncertain significance Single submitter
- SIRT5 p.Val264Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SIRT5 p.Arg127Gln Uncertain significance Single submitter
- SIRT5 p.Asp236Asn Uncertain significance Single submitter
- SIRT5 p.Leu184Phe Uncertain significance Single submitter
- SIRT5 p.Leu297Val Uncertain significance Single submitter
- SIRT5 p.Lys51Glu Uncertain significance Single submitter
- SIRT5 p.Ser185Pro Uncertain significance Single submitter
- SIRT5 p.Val172Met Uncertain significance Single submitter
- SIRT5 p.Val269Met Uncertain significance Single submitter
All SIRT5 variants
Likely benign 5
- p.Arg26Gln Single submitter
- p.Arg97Gln Single submitter
- p.Thr276Met Single submitter
- p.Val136Met Single submitter
- p.Thr295Met No assertion criteria SIRT5-related disorder
Uncertain significance 50
- p.Ala116Thr Single submitter ⚠
- p.Ala149Thr Single submitter ⚠
- p.Ala173Thr Single submitter ⚠
- p.Ala230Thr Single submitter ⚠
- p.Ala230Val Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Arg105Gln Single submitter ⚠
- p.Arg105Trp Single submitter ⚠
- p.Arg106Pro Single submitter ⚠
- p.Arg106Trp Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg147His Single submitter ⚠
- p.Arg147Ser Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Asn175Ser Single submitter
- p.Asp143Asn Single submitter ⚠
- p.Asp236Asn Single submitter ⚠
- p.Cys30Phe Single submitter ⚠
- p.Gln28Arg Single submitter ⚠
- p.Gln5Arg Single submitter ⚠
- p.Glu123Asp Single submitter ⚠
- p.Glu123Gln Single submitter ⚠
- p.Glu208Lys Single submitter ⚠
- p.Glu209Lys Single submitter ⚠
- p.Gly117Arg Single submitter ⚠
- p.Gly193Val Single submitter ⚠
- p.Gly213Arg Single submitter ⚠
- p.Leu128Val Single submitter ⚠
- p.Leu184Phe Single submitter ⚠
- p.Leu297Val Single submitter ⚠
- p.Leu301Pro Single submitter ⚠
- p.Lys177Arg Single submitter ⚠
- p.Lys51Glu Single submitter ⚠
- p.Phe101Leu Single submitter ⚠
- p.Pro218Arg Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro229Ser Single submitter ⚠
- p.Pro68Leu Single submitter ⚠
- p.Pro68Ser Single submitter ⚠
- p.Ser185Pro Single submitter ⚠
- p.Ser96Phe Single submitter ⚠
- p.Thr250Ala Single submitter ⚠
- p.Thr295Arg Single submitter ⚠
- p.Tyr102Cys Single submitter ⚠
- p.Val171Ile Single submitter ⚠
- p.Val172Met Single submitter ⚠
- p.Val221Met Single submitter ⚠
- p.Val264Ala Single submitter ⚠
- p.Val269Met Single submitter ⚠