Sugi Variant

Sugi Variant/SLC10A2

SLC10A2 — 408 ClinVar variants

All ClinVar germline SLC10A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 215 flagged for review →

1 Pathogenic · 2 Likely pathogenic · 23 Conflicting · 12 Benign · 6 Benign/Likely benign · 99 Likely benign · 265 Uncertain significance

Full SLC10A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 215

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 164

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 164

Predictors split 43

The independent predictors disagree with each other — read with care.

All SLC10A2 variants

Pathogenic 1

  • c.584_585+1inv No assertion criteria bile acid malabsorption, primary, 1

Likely pathogenic 2

Conflicting classifications of pathogenicity 23

Benign 12

Benign/Likely benign 6

Likely benign 99

Uncertain significance 265