SLC10A6 — 54 ClinVar variants
All ClinVar germline SLC10A6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
6 Likely benign · 48 Uncertain significance
Full SLC10A6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC10A6 p.Ala198Ser Uncertain significance Single submitter
- SLC10A6 p.Ala216Val Uncertain significance Single submitter
- SLC10A6 p.Ala99Gly Uncertain significance Single submitter
- SLC10A6 p.Arg63Lys Uncertain significance Single submitter
- SLC10A6 p.Asn348Ser Uncertain significance Single submitter
- SLC10A6 p.Asp122Val Uncertain significance Single submitter
- SLC10A6 p.Asp300Gly Uncertain significance Single submitter
- SLC10A6 p.Asp362Ala Uncertain significance Single submitter
- SLC10A6 p.Gln156Glu Uncertain significance Single submitter
- SLC10A6 p.Glu368Lys Uncertain significance Single submitter
- SLC10A6 p.Gly212Val Uncertain significance Single submitter
- SLC10A6 p.Gly77Arg Uncertain significance Single submitter
- SLC10A6 p.His372Tyr Uncertain significance Single submitter
- SLC10A6 p.Ile145Val Uncertain significance Single submitter
- SLC10A6 p.Ile160Val Uncertain significance Single submitter
- SLC10A6 p.Leu20Pro Uncertain significance Single submitter
- SLC10A6 p.Leu24Val Uncertain significance Single submitter
- SLC10A6 p.Leu283Phe Uncertain significance Single submitter
- SLC10A6 p.Leu315Trp Uncertain significance Single submitter
- SLC10A6 p.Leu367Phe Uncertain significance Single submitter
- SLC10A6 p.Lys191Gln Uncertain significance Single submitter
- SLC10A6 p.Lys321Arg Uncertain significance Single submitter
- SLC10A6 p.Lys322Arg Uncertain significance Single submitter
- SLC10A6 p.Lys93Arg Uncertain significance Single submitter
- SLC10A6 p.Met361Val Uncertain significance Single submitter
- SLC10A6 p.Met46Val Uncertain significance Single submitter
- SLC10A6 p.Phe242Val Uncertain significance Single submitter
- SLC10A6 p.Pro12Ser Uncertain significance Single submitter
- SLC10A6 p.Pro360Thr Uncertain significance Single submitter
- SLC10A6 p.Ser153Gly Uncertain significance Single submitter
- SLC10A6 p.Ser16Ala Uncertain significance Single submitter
- SLC10A6 p.Thr168Ala Uncertain significance Single submitter
- SLC10A6 p.Thr225Ala Uncertain significance Single submitter
- SLC10A6 p.Thr240Met Uncertain significance Single submitter
- SLC10A6 p.Thr332Arg Uncertain significance Single submitter
- SLC10A6 p.Thr332Met Uncertain significance Single submitter
- SLC10A6 p.Val203Phe Uncertain significance Single submitter
- SLC10A6 p.Val33Ala Uncertain significance Single submitter
- SLC10A6 p.Val33Ile Uncertain significance Single submitter
- SLC10A6 p.Val370Ile Uncertain significance Single submitter
- SLC10A6 p.Val37Leu Uncertain significance Single submitter
- SLC10A6 p.Val70Glu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All SLC10A6 variants
Likely benign 6
- p.Arg56Gln Single submitter
- p.Ser335Leu Single submitter
- p.Thr310Met Single submitter
- p.Thr82Ile Single submitter
- p.Tyr181Cys Single submitter
- p.Val26Ala Single submitter
Uncertain significance 48
- p.Ala198Ser Single submitter ⚠
- p.Ala216Val Single submitter ⚠
- p.Ala99Gly Single submitter ⚠
- p.Arg63Lys Single submitter ⚠
- p.Asn348Ser Single submitter ⚠
- p.Asp122Val Single submitter ⚠
- p.Asp300Gly Single submitter ⚠
- p.Asp362Ala Single submitter ⚠
- p.Gln156Glu Single submitter ⚠
- p.Glu368Lys Single submitter ⚠
- p.Gly108Ala Single submitter ⚠
- p.Gly212Val Single submitter ⚠
- p.Gly77Arg Single submitter ⚠
- p.His372Tyr Single submitter ⚠
- p.Ile145Val Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Leu20Pro Single submitter ⚠
- p.Leu24Val Single submitter ⚠
- p.Leu283Phe Single submitter ⚠
- p.Leu315Trp Single submitter ⚠
- p.Leu367Phe Single submitter ⚠
- p.Lys191Gln Single submitter ⚠
- p.Lys321Arg Single submitter ⚠
- p.Lys322Arg Single submitter ⚠
- p.Lys93Arg Single submitter ⚠
- p.Met361Val Single submitter ⚠
- p.Met46Val Single submitter ⚠
- p.Phe242Cys Single submitter ⚠
- p.Phe242Val Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro360Thr Single submitter ⚠
- p.Ser153Gly Single submitter ⚠
- p.Ser16Ala Single submitter ⚠
- p.Ser89Arg Single submitter ⚠
- p.Thr131Asn Single submitter ⚠
- p.Thr168Ala Single submitter ⚠
- p.Thr225Ala Single submitter ⚠
- p.Thr240Met Single submitter ⚠
- p.Thr332Arg Single submitter ⚠
- p.Thr332Met Single submitter ⚠
- p.Tyr162His Single submitter
- p.Tyr162Ser Single submitter ⚠
- p.Val203Phe Single submitter ⚠
- p.Val33Ala Single submitter ⚠
- p.Val33Ile Single submitter ⚠
- p.Val370Ile Single submitter ⚠
- p.Val37Leu Single submitter ⚠
- p.Val70Glu Single submitter ⚠