SLC16A3 — 108 ClinVar variants
All ClinVar germline SLC16A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
2 Benign · 15 Likely benign · 91 Uncertain significance
Full SLC16A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC16A3 p.Ala127Val Uncertain significance Single submitter
- SLC16A3 p.Ala235Thr Uncertain significance Single submitter
- SLC16A3 p.Ala281Val Uncertain significance Single submitter
- SLC16A3 p.Ala308Ser Uncertain significance Single submitter
- SLC16A3 p.Ala308Val Uncertain significance Single submitter
- SLC16A3 p.Ala380Gly Uncertain significance Single submitter
- SLC16A3 p.Ala424Thr Uncertain significance Single submitter
- SLC16A3 p.Arg109Gln Uncertain significance Single submitter
- SLC16A3 p.Arg145Cys Uncertain significance Single submitter
- SLC16A3 p.Arg216His Uncertain significance Single submitter
- SLC16A3 p.Arg216Leu Uncertain significance Single submitter
- SLC16A3 p.Arg226Cys Uncertain significance Single submitter
- SLC16A3 p.Arg226His Uncertain significance Single submitter
- SLC16A3 p.Arg291Gln Uncertain significance Single submitter
- SLC16A3 p.Arg411Lys Uncertain significance Single submitter
- SLC16A3 p.Arg441Pro Uncertain significance Single submitter
- SLC16A3 p.Asp225Gly Uncertain significance Single submitter
- SLC16A3 p.Asp260Asn Uncertain significance Single submitter
- SLC16A3 p.Asp317Asn Uncertain significance Single submitter
- SLC16A3 p.Asp435Glu Uncertain significance Single submitter
- SLC16A3 p.Asp439His Uncertain significance Single submitter
- SLC16A3 p.Cys78Tyr Uncertain significance Single submitter
- SLC16A3 p.Gln418Lys Uncertain significance Single submitter
- SLC16A3 p.Glu425Lys Uncertain significance Single submitter
- SLC16A3 p.Glu426Lys Uncertain significance Single submitter
- SLC16A3 p.Gly179Ser Uncertain significance Single submitter
- SLC16A3 p.Gly209Glu Uncertain significance Single submitter
- SLC16A3 p.Gly227Ser Uncertain significance Single submitter
- SLC16A3 p.Gly370Arg Uncertain significance Single submitter
- SLC16A3 p.Gly3Val Uncertain significance Single submitter
- SLC16A3 p.Gly455Glu Uncertain significance Single submitter
- SLC16A3 p.Gly56Arg Uncertain significance Single submitter
- SLC16A3 p.Ile135Val Uncertain significance Single submitter
- SLC16A3 p.Ile273Thr Uncertain significance Single submitter
- SLC16A3 p.Ile273Val Uncertain significance Single submitter
- SLC16A3 p.Leu218Ile Uncertain significance Single submitter
- SLC16A3 p.Leu310Val Uncertain significance Single submitter
- SLC16A3 p.Leu396Arg Uncertain significance Single submitter
- SLC16A3 p.Leu402Phe Uncertain significance Single submitter
- SLC16A3 p.Met197Thr Uncertain significance Single submitter
- SLC16A3 p.Met385Thr Uncertain significance Single submitter
- SLC16A3 p.Phe407Tyr Uncertain significance Single submitter
- SLC16A3 p.Pro165Leu Uncertain significance Single submitter
- SLC16A3 p.Pro211Arg Uncertain significance Single submitter
- SLC16A3 p.Pro213His Uncertain significance Single submitter
- SLC16A3 p.Pro245Leu Uncertain significance Single submitter
- SLC16A3 p.Pro279Leu Uncertain significance Single submitter
- SLC16A3 p.Pro419Leu Uncertain significance Single submitter
- SLC16A3 p.Pro461Ala Uncertain significance Single submitter
- SLC16A3 p.Pro461Leu Uncertain significance Single submitter
- SLC16A3 p.Ser133Leu Uncertain significance Single submitter
- SLC16A3 p.Ser373Leu Uncertain significance Single submitter
- SLC16A3 p.Ser64Phe Uncertain significance Single submitter
- SLC16A3 p.Ser99Leu Uncertain significance Single submitter
- SLC16A3 p.Thr203Met Uncertain significance Single submitter
- SLC16A3 p.Trp176Arg Uncertain significance Single submitter
- SLC16A3 p.Trp62Cys Uncertain significance Single submitter
- SLC16A3 p.Tyr174Asp Uncertain significance Single submitter
- SLC16A3 p.Tyr231His Uncertain significance Single submitter
- SLC16A3 p.Val233Met Uncertain significance Single submitter
- SLC16A3 p.Val239Ala Uncertain significance Single submitter
- SLC16A3 p.Val24Met Uncertain significance Single submitter
- SLC16A3 p.Val250Met Uncertain significance Single submitter
- SLC16A3 p.Val258Leu Uncertain significance Single submitter
- SLC16A3 p.Val438Met Uncertain significance Single submitter
- SLC16A3 p.Val5Met Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- SLC16A3 p.Ala391Val Uncertain significance Single submitter
- SLC16A3 p.Arg173Cys Uncertain significance Single submitter
- SLC16A3 p.Arg216Cys Uncertain significance Single submitter
- SLC16A3 p.Arg84His Uncertain significance Single submitter
- SLC16A3 p.Asn138Lys Uncertain significance Single submitter
- SLC16A3 p.Asp260Val Uncertain significance Single submitter
- SLC16A3 p.Cys191Gly Uncertain significance Single submitter
- SLC16A3 p.Gly175Ser Uncertain significance Single submitter
- SLC16A3 p.Gly437Arg Likely benign Single submitter
- SLC16A3 p.Ile182Phe Uncertain significance Single submitter
- SLC16A3 p.Leu71Phe Uncertain significance Single submitter
- SLC16A3 p.Phe276Leu Uncertain significance Single submitter
- SLC16A3 p.Phe300Leu Uncertain significance Single submitter
- SLC16A3 p.Phe34Leu Uncertain significance Single submitter
- SLC16A3 p.Pro371Ser Uncertain significance Single submitter
- SLC16A3 p.Ser313Pro Uncertain significance Single submitter
- SLC16A3 p.Ser398Thr Uncertain significance Single submitter
- SLC16A3 p.Thr32Ile Uncertain significance Single submitter
- SLC16A3 p.Val247Met Uncertain significance Single submitter
- SLC16A3 p.Val387Met Uncertain significance Single submitter
All SLC16A3 variants
Benign 2
- p.Ala15Val Multiple submitters
- p.Ala277= Single submitter
Likely benign 15
- p.Pro89= Multiple submitters
- p.Ala308Thr Single submitter
- p.Ala422Val Single submitter
- p.Arg173His Single submitter
- p.Asn454= Single submitter
- p.Gln205Arg Single submitter
- p.Gln51Arg Single submitter
- p.Glu425= Single submitter
- p.Gly437Arg Single submitter ⚠
- p.Pro210Leu Single submitter
- p.Ser58= Single submitter
- p.Ser99= Single submitter
- p.Val13Ile Single submitter
- p.Val244Ile Single submitter
- p.Val369Ile Single submitter
Uncertain significance 91
- p.Ala127Val Single submitter ⚠
- p.Ala235Thr Single submitter ⚠
- p.Ala277Thr Single submitter
- p.Ala281Val Single submitter ⚠
- p.Ala308Ser Single submitter ⚠
- p.Ala308Val Single submitter ⚠
- p.Ala380Gly Single submitter ⚠
- p.Ala391Val Single submitter ⚠
- p.Ala424Thr Single submitter ⚠
- p.Arg109Gln Single submitter ⚠
- p.Arg145Cys Single submitter ⚠
- p.Arg173Cys Single submitter ⚠
- p.Arg216Cys Single submitter ⚠
- p.Arg216His Single submitter ⚠
- p.Arg216Leu Single submitter ⚠
- p.Arg226Cys Single submitter ⚠
- p.Arg226His Single submitter ⚠
- p.Arg291Gln Single submitter ⚠
- p.Arg411Lys Single submitter ⚠
- p.Arg441Pro Single submitter ⚠
- p.Arg84His Single submitter ⚠
- p.Asn138Lys Single submitter ⚠
- p.Asn305Ser Single submitter
- p.Asp225Gly Single submitter ⚠
- p.Asp260Asn Single submitter ⚠
- p.Asp260Val Single submitter ⚠
- p.Asp317Asn Single submitter ⚠
- p.Asp435Glu Single submitter ⚠
- p.Asp439His Single submitter ⚠
- p.Cys191Gly Single submitter ⚠
- p.Cys78Tyr Single submitter ⚠
- p.Gln418Lys Single submitter ⚠
- p.Glu425Lys Single submitter ⚠
- p.Glu426Lys Single submitter ⚠
- p.Gly175Ser Single submitter ⚠
- p.Gly179Ser Single submitter ⚠
- p.Gly209Glu Single submitter ⚠
- p.Gly227Ser Single submitter ⚠
- p.Gly27Ser Single submitter
- p.Gly370Arg Single submitter ⚠
- p.Gly3Val Single submitter ⚠
- p.Gly455Glu Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.Ile135Val Single submitter ⚠
- p.Ile182Phe Single submitter ⚠
- p.Ile273Thr Single submitter ⚠
- p.Ile273Val Single submitter ⚠
- p.Leu218Ile Single submitter ⚠
- p.Leu310Val Single submitter ⚠
- p.Leu396Arg Single submitter ⚠
- p.Leu402Phe Single submitter ⚠
- p.Leu71Phe Single submitter ⚠
- p.Met197Thr Single submitter ⚠
- p.Met385Thr Single submitter ⚠
- p.Phe276Leu Single submitter ⚠
- p.Phe300Leu Single submitter ⚠
- p.Phe34Leu Single submitter ⚠
- p.Phe407Tyr Single submitter ⚠
- p.Pro165Leu Single submitter ⚠
- p.Pro211Arg Single submitter ⚠
- p.Pro213His Single submitter ⚠
- p.Pro245Leu Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro292Leu Single submitter
- p.Pro371Ser Single submitter ⚠
- p.Pro419Leu Single submitter ⚠
- p.Pro461Ala Single submitter ⚠
- p.Pro461Leu Single submitter ⚠
- p.Ser133Leu Single submitter ⚠
- p.Ser313Pro Single submitter ⚠
- p.Ser35Cys Single submitter
- p.Ser373Leu Single submitter ⚠
- p.Ser398Thr Single submitter ⚠
- p.Ser64Phe Single submitter ⚠
- p.Ser99Leu Single submitter ⚠
- p.Thr122Met Single submitter
- p.Thr203Met Single submitter ⚠
- p.Thr32Ile Single submitter ⚠
- p.Trp176Arg Single submitter ⚠
- p.Trp62Cys Single submitter ⚠
- p.Tyr174Asp Single submitter ⚠
- p.Tyr231His Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val239Ala Single submitter ⚠
- p.Val247Met Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val250Met Single submitter ⚠
- p.Val258Leu Single submitter ⚠
- p.Val387Met Single submitter ⚠
- p.Val438Met Single submitter ⚠
- p.Val5Met Single submitter ⚠