SLC16A6 — 85 ClinVar variants
All ClinVar germline SLC16A6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
2 Benign · 14 Likely benign · 69 Uncertain significance
Full SLC16A6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC16A6 p.Ala209Val Uncertain significance Single submitter
- SLC16A6 p.Ala281Ser Uncertain significance Single submitter
- SLC16A6 p.Ala281Val Uncertain significance Single submitter
- SLC16A6 p.Ala304Val Uncertain significance Single submitter
- SLC16A6 p.Arg148Cys Uncertain significance Single submitter
- SLC16A6 p.Arg176His Uncertain significance Single submitter
- SLC16A6 p.Arg176Ser Uncertain significance Single submitter
- SLC16A6 p.Arg206Gly Uncertain significance Single submitter
- SLC16A6 p.Arg219Gln Uncertain significance Single submitter
- SLC16A6 p.Asn13Ser Uncertain significance Single submitter
- SLC16A6 p.Asn512Ser Uncertain significance Single submitter
- SLC16A6 p.Asn512Thr Uncertain significance Single submitter
- SLC16A6 p.Asn60Ser Uncertain significance Single submitter
- SLC16A6 p.Gln112Lys Uncertain significance Single submitter
- SLC16A6 p.Gln216Arg Uncertain significance Single submitter
- SLC16A6 p.Glu258Gln Uncertain significance Single submitter
- SLC16A6 p.Glu278Lys Uncertain significance Single submitter
- SLC16A6 p.Glu362Val Uncertain significance Single submitter
- SLC16A6 p.Gly128Glu Uncertain significance Single submitter
- SLC16A6 p.Gly207Arg Uncertain significance Single submitter
- SLC16A6 p.Gly89Arg Uncertain significance Single submitter
- SLC16A6 p.Gly98Glu Uncertain significance Single submitter
- SLC16A6 p.His514Gln Uncertain significance Single submitter
- SLC16A6 p.Ile193Val Uncertain significance Single submitter
- SLC16A6 p.Ile238Val Uncertain significance Single submitter
- SLC16A6 p.Ile315Ser Uncertain significance Single submitter
- SLC16A6 p.Leu302Ile Uncertain significance Single submitter
- SLC16A6 p.Met265Thr Uncertain significance Single submitter
- SLC16A6 p.Met476Thr Uncertain significance Single submitter
- SLC16A6 p.Phe303Leu Uncertain significance Single submitter
- SLC16A6 p.Phe45Ser Uncertain significance Single submitter
- SLC16A6 p.Pro311Ser Uncertain significance Single submitter
- SLC16A6 p.Ser277Arg Uncertain significance Single submitter
- SLC16A6 p.Ser277Asn Uncertain significance Single submitter
- SLC16A6 p.Ser55Thr Uncertain significance Single submitter
- SLC16A6 p.Ser59Phe Uncertain significance Single submitter
- SLC16A6 p.Ser85Cys Uncertain significance Single submitter
- SLC16A6 p.Thr245Pro Uncertain significance Single submitter
- SLC16A6 p.Thr246Pro Uncertain significance Single submitter
- SLC16A6 p.Thr272Asn Uncertain significance Single submitter
- SLC16A6 p.Thr2Ser Uncertain significance Single submitter
- SLC16A6 p.Thr402Asn Uncertain significance Single submitter
- SLC16A6 p.Tyr297His Uncertain significance Single submitter
- SLC16A6 p.Val154Ala Uncertain significance Single submitter
- SLC16A6 p.Val29Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- SLC16A6 p.Ala162Thr Uncertain significance Single submitter
- SLC16A6 p.Ala26Thr Uncertain significance Single submitter
- SLC16A6 p.Ala329Thr Uncertain significance Single submitter
- SLC16A6 p.Ala339Thr Likely benign Single submitter
- SLC16A6 p.Arg219Trp Uncertain significance Single submitter
- SLC16A6 p.Arg232Gln Uncertain significance Single submitter
- SLC16A6 p.Arg328Cys Uncertain significance Single submitter
- SLC16A6 p.Arg493Cys Uncertain significance Single submitter
- SLC16A6 p.Arg87His Uncertain significance Single submitter
- SLC16A6 p.Arg91His Uncertain significance Single submitter
- SLC16A6 p.Gln142Arg Uncertain significance Single submitter
- SLC16A6 p.Glu291Gln Uncertain significance Single submitter
- SLC16A6 p.Ile203Met Uncertain significance Single submitter
- SLC16A6 p.Ile338Thr Uncertain significance Single submitter
- SLC16A6 p.Ile345Met Uncertain significance Single submitter
- SLC16A6 p.Ile431Met Uncertain significance Single submitter
- SLC16A6 p.Leu226Val Uncertain significance Single submitter
- SLC16A6 p.Met117Thr Uncertain significance Single submitter
- SLC16A6 p.Phe110Val Uncertain significance Single submitter
- SLC16A6 p.Phe37Leu Uncertain significance Single submitter
- SLC16A6 p.Pro282Leu Uncertain significance Single submitter
- SLC16A6 p.Ser85Ile Uncertain significance Single submitter
- SLC16A6 p.Thr245Ile Uncertain significance Single submitter
- SLC16A6 p.Val194Gly Uncertain significance Single submitter
- SLC16A6 p.Val366Ile Uncertain significance Single submitter
- SLC16A6 p.Val518Met Likely benign Single submitter
All SLC16A6 variants
Likely benign 14
- p.Ala120Thr Single submitter
- p.Ala222Val Single submitter
- p.Ala26= Single submitter
- p.Ala26Val Single submitter
- p.Ala339Thr Single submitter ⚠
- p.Ile195Val Single submitter
- p.Ile213Thr Single submitter
- p.Ile404= Single submitter
- p.Leu183= Single submitter
- p.Leu257Pro Single submitter
- p.Thr103= Single submitter
- p.Val268Ile Single submitter
- p.Val34Ile Single submitter
- p.Val518Met Single submitter ⚠
Uncertain significance 69
- p.Ala162Thr Single submitter ⚠
- p.Ala209Val Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Ala281Ser Single submitter ⚠
- p.Ala281Val Single submitter ⚠
- p.Ala304Val Single submitter ⚠
- p.Ala329Thr Single submitter ⚠
- p.Arg148Cys Single submitter ⚠
- p.Arg176His Single submitter ⚠
- p.Arg176Ser Single submitter ⚠
- p.Arg206Gly Single submitter ⚠
- p.Arg219Gln Single submitter ⚠
- p.Arg219Trp Single submitter ⚠
- p.Arg232Gln Single submitter ⚠
- p.Arg328Cys Single submitter ⚠
- p.Arg493Cys Single submitter ⚠
- p.Arg87His Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Asn13Ser Single submitter ⚠
- p.Asn512Ser Single submitter ⚠
- p.Asn512Thr Single submitter ⚠
- p.Asn60Ser Single submitter ⚠
- p.Gln112Lys Single submitter ⚠
- p.Gln142Arg Single submitter ⚠
- p.Gln216Arg Single submitter ⚠
- p.Glu258Gln Single submitter ⚠
- p.Glu278Lys Single submitter ⚠
- p.Glu291Gln Single submitter ⚠
- p.Glu362Val Single submitter ⚠
- p.Gly128Glu Single submitter ⚠
- p.Gly207Arg Single submitter ⚠
- p.Gly89Arg Single submitter ⚠
- p.Gly98Glu Single submitter ⚠
- p.His514Gln Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Ile203Met Single submitter ⚠
- p.Ile238Val Single submitter ⚠
- p.Ile315Ser Single submitter ⚠
- p.Ile338Thr Single submitter ⚠
- p.Ile345Met Single submitter ⚠
- p.Ile431Met Single submitter ⚠
- p.Leu226Val Single submitter ⚠
- p.Leu302Ile Single submitter ⚠
- p.Met117Thr Single submitter ⚠
- p.Met265Thr Single submitter ⚠
- p.Met476Thr Single submitter ⚠
- p.Phe110Val Single submitter ⚠
- p.Phe303Leu Single submitter ⚠
- p.Phe37Leu Single submitter ⚠
- p.Phe45Ser Single submitter ⚠
- p.Pro282Leu Single submitter ⚠
- p.Pro311Ser Single submitter ⚠
- p.Ser277Arg Single submitter ⚠
- p.Ser277Asn Single submitter ⚠
- p.Ser55Thr Single submitter ⚠
- p.Ser59Phe Single submitter ⚠
- p.Ser85Cys Single submitter ⚠
- p.Ser85Ile Single submitter ⚠
- p.Thr245Ile Single submitter ⚠
- p.Thr245Pro Single submitter ⚠
- p.Thr246Pro Single submitter ⚠
- p.Thr272Asn Single submitter ⚠
- p.Thr2Ser Single submitter ⚠
- p.Thr402Asn Single submitter ⚠
- p.Tyr297His Single submitter ⚠
- p.Val154Ala Single submitter ⚠
- p.Val194Gly Single submitter ⚠
- p.Val29Ile Single submitter ⚠
- p.Val366Ile Single submitter ⚠