SLC2A8 — 62 ClinVar variants
All ClinVar germline SLC2A8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
2 Benign · 3 Likely benign · 57 Uncertain significance
Full SLC2A8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC2A8 p.Ala175Pro Uncertain significance Single submitter
- SLC2A8 p.Ala220Val Uncertain significance Single submitter
- SLC2A8 p.Ala239Asp Uncertain significance Single submitter
- SLC2A8 p.Arg127Cys Uncertain significance Single submitter
- SLC2A8 p.Arg182Cys Uncertain significance Single submitter
- SLC2A8 p.Arg207Cys Uncertain significance Single submitter
- SLC2A8 p.Arg249Trp Uncertain significance Single submitter
- SLC2A8 p.Arg318Trp Uncertain significance Single submitter
- SLC2A8 p.Asp66Tyr Uncertain significance Single submitter
- SLC2A8 p.Gln302Pro Uncertain significance Single submitter
- SLC2A8 p.Gln362Lys Uncertain significance Single submitter
- SLC2A8 p.Glu217Asp Uncertain significance Single submitter
- SLC2A8 p.Gly155Glu Uncertain significance Single submitter
- SLC2A8 p.Gly155Val Uncertain significance Single submitter
- SLC2A8 p.Gly168Ser Uncertain significance Single submitter
- SLC2A8 p.Gly252Cys Uncertain significance Single submitter
- SLC2A8 p.Gly252Ser Uncertain significance Single submitter
- SLC2A8 p.Gly384Asp Uncertain significance Single submitter
- SLC2A8 p.His352Gln Uncertain significance Single submitter
- SLC2A8 p.His404Asn Uncertain significance Single submitter
- SLC2A8 p.Ile259Val Uncertain significance Single submitter
- SLC2A8 p.Leu179Pro Uncertain significance Single submitter
- SLC2A8 p.Leu248Pro Uncertain significance Single submitter
- SLC2A8 p.Leu324Phe Uncertain significance Single submitter
- SLC2A8 p.Lys287Thr Uncertain significance Single submitter
- SLC2A8 p.Phe381Leu Uncertain significance Single submitter
- SLC2A8 p.Phe428Cys Uncertain significance Single submitter
- SLC2A8 p.Phe457Leu Uncertain significance Single submitter
- SLC2A8 p.Pro235Ala Uncertain significance Single submitter
- SLC2A8 p.Pro236Arg Uncertain significance Single submitter
- SLC2A8 p.Pro347Ser Uncertain significance Single submitter
- SLC2A8 p.Ser242Thr Uncertain significance Single submitter
- SLC2A8 p.Ser270Leu Uncertain significance Single submitter
- SLC2A8 p.Ser270Trp Uncertain significance Single submitter
- SLC2A8 p.Ser332Arg Uncertain significance Single submitter
- SLC2A8 p.Thr455Ala Uncertain significance Single submitter
- SLC2A8 p.Val190Met Uncertain significance Single submitter
- SLC2A8 p.Val308Met Uncertain significance Single submitter
- SLC2A8 p.Val368Leu Uncertain significance Single submitter
- SLC2A8 p.Val408Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- SLC2A8 p.Arg207His Uncertain significance Single submitter
- SLC2A8 p.Cys160Tyr Uncertain significance Single submitter
- SLC2A8 p.Glu204Lys Uncertain significance Single submitter
- SLC2A8 p.Glu217Lys Uncertain significance Single submitter
- SLC2A8 p.Gly384Ala Uncertain significance Single submitter
- SLC2A8 p.Gly476Glu Uncertain significance Single submitter
- SLC2A8 p.His213Tyr Uncertain significance Single submitter
- SLC2A8 p.Ile145Asn Uncertain significance Single submitter
- SLC2A8 p.Leu396Phe Uncertain significance Single submitter
- SLC2A8 p.Lys426Arg Uncertain significance Single submitter
- SLC2A8 p.Met199Ile Uncertain significance Single submitter
- SLC2A8 p.Met276Thr Uncertain significance Single submitter
- SLC2A8 p.Ser351Leu Uncertain significance Single submitter
- SLC2A8 p.Trp183Arg Uncertain significance Single submitter
All SLC2A8 variants
Benign 2
- p.Ile237fs Single submitter
- p.Ser193Phe Single submitter
Likely benign 3
- p.Ala338Thr Single submitter
- p.Leu132= Single submitter
- p.Val353Met Single submitter
Uncertain significance 57
- p.Ala175Pro Single submitter ⚠
- p.Ala220Val Single submitter ⚠
- p.Ala239Asp Single submitter ⚠
- p.Arg127Cys Single submitter ⚠
- p.Arg182Cys Single submitter ⚠
- p.Arg207Cys Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg249Trp Single submitter ⚠
- p.Arg318Trp Single submitter ⚠
- p.Asp66Tyr Single submitter ⚠
- p.Cys160Tyr Single submitter ⚠
- p.Gln302Pro Single submitter ⚠
- p.Gln362Lys Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Glu217Asp Single submitter ⚠
- p.Glu217Lys Single submitter ⚠
- p.Gly155Glu Single submitter ⚠
- p.Gly155Val Single submitter ⚠
- p.Gly168Ser Single submitter ⚠
- p.Gly252Cys Single submitter ⚠
- p.Gly252Ser Single submitter ⚠
- p.Gly384Ala Single submitter ⚠
- p.Gly384Asp Single submitter ⚠
- p.Gly476Glu Single submitter ⚠
- p.His213Tyr Single submitter ⚠
- p.His352Gln Single submitter ⚠
- p.His404Asn Single submitter ⚠
- p.Ile145Asn Single submitter ⚠
- p.Ile253Asn Single submitter
- p.Ile259Val Single submitter ⚠
- p.Leu179Pro Single submitter ⚠
- p.Leu248Pro Single submitter ⚠
- p.Leu324Phe Single submitter ⚠
- p.Leu396Phe Single submitter ⚠
- p.Lys287Thr Single submitter ⚠
- p.Lys426Arg Single submitter ⚠
- p.Met199Ile Single submitter ⚠
- p.Met276Thr Single submitter ⚠
- p.Phe201Leu Single submitter
- p.Phe381Leu Single submitter ⚠
- p.Phe428Cys Single submitter ⚠
- p.Phe457Leu Single submitter ⚠
- p.Pro151Arg Single submitter
- p.Pro235Ala Single submitter ⚠
- p.Pro236Arg Single submitter ⚠
- p.Pro347Ser Single submitter ⚠
- p.Ser242Thr Single submitter ⚠
- p.Ser270Leu Single submitter ⚠
- p.Ser270Trp Single submitter ⚠
- p.Ser332Arg Single submitter ⚠
- p.Ser351Leu Single submitter ⚠
- p.Thr455Ala Single submitter ⚠
- p.Trp183Arg Single submitter ⚠
- p.Val190Met Single submitter ⚠
- p.Val308Met Single submitter ⚠
- p.Val368Leu Single submitter ⚠
- p.Val408Leu Single submitter ⚠