SLC38A7 — 52 ClinVar variants
All ClinVar germline SLC38A7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
3 Benign · 49 Uncertain significance
Full SLC38A7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC38A7 p.Ala104Ser Uncertain significance Single submitter
- SLC38A7 p.Ala289Thr Uncertain significance Single submitter
- SLC38A7 p.Ala403Ser Uncertain significance Single submitter
- SLC38A7 p.Arg24Pro Uncertain significance Single submitter
- SLC38A7 p.Arg353His Uncertain significance Single submitter
- SLC38A7 p.Arg367Gln Uncertain significance Single submitter
- SLC38A7 p.Asn454Ser Uncertain significance Single submitter
- SLC38A7 p.Cys106Tyr Uncertain significance Single submitter
- SLC38A7 p.Cys123Arg Uncertain significance Single submitter
- SLC38A7 p.Gln27Lys Uncertain significance Single submitter
- SLC38A7 p.Gln355His Uncertain significance Single submitter
- SLC38A7 p.Gly167Arg Uncertain significance Single submitter
- SLC38A7 p.Gly232Ala Uncertain significance Single submitter
- SLC38A7 p.Gly392Ser Uncertain significance Single submitter
- SLC38A7 p.Gly66Val Uncertain significance Single submitter
- SLC38A7 p.Gly81Cys Uncertain significance Single submitter
- SLC38A7 p.Ile219Thr Uncertain significance Single submitter
- SLC38A7 p.Leu460Phe Uncertain significance Single submitter
- SLC38A7 p.Leu65Arg Uncertain significance Single submitter
- SLC38A7 p.Lys177Arg Uncertain significance Single submitter
- SLC38A7 p.Lys36Arg Uncertain significance Single submitter
- SLC38A7 p.Met248Val Uncertain significance Single submitter
- SLC38A7 p.Met319Thr Uncertain significance Single submitter
- SLC38A7 p.Phe407Ser Uncertain significance Single submitter
- SLC38A7 p.Pro238Ser Uncertain significance Single submitter
- SLC38A7 p.Ser267Gly Uncertain significance Single submitter
- SLC38A7 p.Ser316Leu Uncertain significance Single submitter
- SLC38A7 p.Thr17Met Uncertain significance Single submitter
- SLC38A7 p.Thr374Met Uncertain significance Single submitter
- SLC38A7 p.Thr452Lys Uncertain significance Single submitter
- SLC38A7 p.Thr50Ile Uncertain significance Single submitter
- SLC38A7 p.Trp276Leu Uncertain significance Single submitter
- SLC38A7 p.Val323Ile Uncertain significance Single submitter
- SLC38A7 p.Val359Met Uncertain significance Single submitter
- SLC38A7 p.Val394Leu Uncertain significance Single submitter
- SLC38A7 p.Val60Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- SLC38A7 p.Ala184Val Uncertain significance Single submitter
- SLC38A7 p.Ala283Thr Uncertain significance Single submitter
- SLC38A7 p.Ala403Thr Uncertain significance Single submitter
- SLC38A7 p.Ala455Val Uncertain significance Single submitter
- SLC38A7 p.Ala63Thr Uncertain significance Single submitter
- SLC38A7 p.Gln373Lys Uncertain significance Single submitter
- SLC38A7 p.Gly449Ser Uncertain significance Single submitter
- SLC38A7 p.Phe448Val Uncertain significance Single submitter
- SLC38A7 p.Tyr138His Uncertain significance Single submitter
- SLC38A7 p.Val306Met Uncertain significance Single submitter
- SLC38A7 p.Val310Met Uncertain significance Single submitter
- SLC38A7 p.Val321Met Uncertain significance Single submitter
All SLC38A7 variants
Benign 3
- p.Asn454= Multiple submitters
- p.Tyr10Cys Multiple submitters
- p.Leu288= Single submitter
Uncertain significance 49
- p.Ala104Ser Single submitter ⚠
- p.Ala184Val Single submitter ⚠
- p.Ala283Thr Single submitter ⚠
- p.Ala289Thr Single submitter ⚠
- p.Ala345Val Single submitter
- p.Ala403Ser Single submitter ⚠
- p.Ala403Thr Single submitter ⚠
- p.Ala455Val Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Arg24Pro Single submitter ⚠
- p.Arg353His Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Asn454Ser Single submitter ⚠
- p.Cys106Tyr Single submitter ⚠
- p.Cys123Arg Single submitter ⚠
- p.Gln27Lys Single submitter ⚠
- p.Gln355His Single submitter ⚠
- p.Gln373Lys Single submitter ⚠
- p.Gly167Arg Single submitter ⚠
- p.Gly232Ala Single submitter ⚠
- p.Gly392Ser Single submitter ⚠
- p.Gly449Ser Single submitter ⚠
- p.Gly66Val Single submitter ⚠
- p.Gly81Cys Single submitter ⚠
- p.Ile219Thr Single submitter ⚠
- p.Leu460Phe Single submitter ⚠
- p.Leu65Arg Single submitter ⚠
- p.Lys177Arg Single submitter ⚠
- p.Lys36Arg Single submitter ⚠
- p.Met248Val Single submitter ⚠
- p.Met319Thr Single submitter ⚠
- p.Phe407Ser Single submitter ⚠
- p.Phe448Val Single submitter ⚠
- p.Pro238Ser Single submitter ⚠
- p.Ser267Gly Single submitter ⚠
- p.Ser316Leu Single submitter ⚠
- p.Thr17Met Single submitter ⚠
- p.Thr374Met Single submitter ⚠
- p.Thr452Lys Single submitter ⚠
- p.Thr50Ile Single submitter ⚠
- p.Trp276Leu Single submitter ⚠
- p.Tyr138His Single submitter ⚠
- p.Val306Met Single submitter ⚠
- p.Val310Met Single submitter ⚠
- p.Val321Met Single submitter ⚠
- p.Val323Ile Single submitter ⚠
- p.Val359Met Single submitter ⚠
- p.Val394Leu Single submitter ⚠
- p.Val60Ile Single submitter ⚠