SLC39A3 — 72 ClinVar variants
All ClinVar germline SLC39A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Benign · 1 Likely benign · 70 Uncertain significance
Full SLC39A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC39A3 p.Ala123Thr Uncertain significance Single submitter
- SLC39A3 p.Ala141Thr Uncertain significance Single submitter
- SLC39A3 p.Ala141Val Uncertain significance Single submitter
- SLC39A3 p.Ala145Thr Uncertain significance Single submitter
- SLC39A3 p.Ala145Val Uncertain significance Single submitter
- SLC39A3 p.Ala165Thr Uncertain significance Single submitter
- SLC39A3 p.Ala187Asp Uncertain significance Single submitter
- SLC39A3 p.Ala229Thr Uncertain significance Single submitter
- SLC39A3 p.Ala229Val Uncertain significance Single submitter
- SLC39A3 p.Ala238Thr Uncertain significance Single submitter
- SLC39A3 p.Ala253Thr Uncertain significance Single submitter
- SLC39A3 p.Ala269Val Uncertain significance Single submitter
- SLC39A3 p.Arg109Cys Uncertain significance Single submitter
- SLC39A3 p.Arg109Leu Uncertain significance Single submitter
- SLC39A3 p.Arg169Cys Uncertain significance Single submitter
- SLC39A3 p.Arg227Gln Uncertain significance Single submitter
- SLC39A3 p.Arg227Trp Uncertain significance Single submitter
- SLC39A3 p.Arg39Cys Uncertain significance Single submitter
- SLC39A3 p.Arg39Pro Uncertain significance Single submitter
- SLC39A3 p.Asp130Asn Uncertain significance Single submitter
- SLC39A3 p.Asp228Glu Uncertain significance Single submitter
- SLC39A3 p.Glu288Gly Uncertain significance Single submitter
- SLC39A3 p.Gly124Arg Uncertain significance Single submitter
- SLC39A3 p.Gly140Asp Uncertain significance Single submitter
- SLC39A3 p.Gly154Cys Uncertain significance Single submitter
- SLC39A3 p.Gly161Asp Uncertain significance Single submitter
- SLC39A3 p.Gly161Ser Uncertain significance Single submitter
- SLC39A3 p.Gly185Cys Uncertain significance Single submitter
- SLC39A3 p.Gly203Arg Uncertain significance Single submitter
- SLC39A3 p.Gly22Ser Uncertain significance Single submitter
- SLC39A3 p.Gly271Ser Uncertain significance Single submitter
- SLC39A3 p.His38Tyr Uncertain significance Single submitter
- SLC39A3 p.Ile250Val Uncertain significance Single submitter
- SLC39A3 p.Ile29Thr Uncertain significance Single submitter
- SLC39A3 p.Leu24Pro Uncertain significance Single submitter
- SLC39A3 p.Lys110Glu Uncertain significance Single submitter
- SLC39A3 p.Lys41Arg Uncertain significance Single submitter
- SLC39A3 p.Met138Ile Uncertain significance Single submitter
- SLC39A3 p.Met224Ile Uncertain significance Single submitter
- SLC39A3 p.Phe17Leu Uncertain significance Single submitter
- SLC39A3 p.Phe55Cys Uncertain significance Single submitter
- SLC39A3 p.Pro113Leu Uncertain significance Single submitter
- SLC39A3 p.Pro225Ser Uncertain significance Single submitter
- SLC39A3 p.Pro225Thr Uncertain significance Single submitter
- SLC39A3 p.Pro257Leu Uncertain significance Single submitter
- SLC39A3 p.Ser125Leu Uncertain significance Single submitter
- SLC39A3 p.Ser135Asn Uncertain significance Single submitter
- SLC39A3 p.Ser158Asn Uncertain significance Single submitter
- SLC39A3 p.Ser163Leu Uncertain significance Single submitter
- SLC39A3 p.Ser222Asn Uncertain significance Single submitter
- SLC39A3 p.Ser252Arg Uncertain significance Single submitter
- SLC39A3 p.Ser252Asn Uncertain significance Single submitter
- SLC39A3 p.Thr49Ile Uncertain significance Single submitter
- SLC39A3 p.Val127Leu Uncertain significance Single submitter
- SLC39A3 p.Val159Ala Uncertain significance Single submitter
- SLC39A3 p.Val202Met Uncertain significance Single submitter
- SLC39A3 p.Val213Met Uncertain significance Single submitter
- SLC39A3 p.Val236Ile Uncertain significance Single submitter
- SLC39A3 p.Val263Met Uncertain significance Single submitter
- SLC39A3 p.Val305Ala Uncertain significance Single submitter
- SLC39A3 p.Val74Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SLC39A3 p.Ala176Val Uncertain significance Single submitter
- SLC39A3 p.Arg142Trp Uncertain significance Single submitter
- SLC39A3 p.Asp130Val Uncertain significance Single submitter
- SLC39A3 p.Glu208Lys Uncertain significance Single submitter
- SLC39A3 p.Gly308Arg Uncertain significance Single submitter
- SLC39A3 p.Phe16Leu Uncertain significance Single submitter
- SLC39A3 p.Phe60Leu Uncertain significance Single submitter
- SLC39A3 p.Val54Leu Uncertain significance Single submitter
All SLC39A3 variants
Benign 1
- p.Arg169His Multiple submitters
Likely benign 1
- p.Val206Ile Single submitter
Uncertain significance 70
- p.Ala123Thr Single submitter ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala141Val Single submitter ⚠
- p.Ala145Thr Single submitter ⚠
- p.Ala145Val Single submitter ⚠
- p.Ala165Thr Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala187Asp Single submitter ⚠
- p.Ala229Thr Single submitter ⚠
- p.Ala229Val Single submitter ⚠
- p.Ala238Thr Single submitter ⚠
- p.Ala253Thr Single submitter ⚠
- p.Ala269Val Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg109Leu Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg169Cys Single submitter ⚠
- p.Arg227Gln Single submitter ⚠
- p.Arg227Trp Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Arg39Pro Single submitter ⚠
- p.Asp130Asn Single submitter ⚠
- p.Asp130Val Single submitter ⚠
- p.Asp228Glu Single submitter ⚠
- p.Glu208Lys Single submitter ⚠
- p.Glu288Gly Single submitter ⚠
- p.Gly124Arg Single submitter ⚠
- p.Gly140Asp Single submitter ⚠
- p.Gly154Cys Single submitter ⚠
- p.Gly161Asp Single submitter ⚠
- p.Gly161Ser Single submitter ⚠
- p.Gly185Cys Single submitter ⚠
- p.Gly203Arg Single submitter ⚠
- p.Gly22Ser Single submitter ⚠
- p.Gly271Ser Single submitter ⚠
- p.Gly308Arg Single submitter ⚠
- p.His38Tyr Single submitter ⚠
- p.Ile250Val Single submitter ⚠
- p.Ile29Thr Single submitter ⚠
- p.Leu24Pro Single submitter ⚠
- p.Lys110Glu Single submitter ⚠
- p.Lys41Arg Single submitter ⚠
- p.Met138Ile Single submitter ⚠
- p.Met224Ile Single submitter ⚠
- p.Phe16Leu Single submitter ⚠
- p.Phe17Leu Single submitter ⚠
- p.Phe55Cys Single submitter ⚠
- p.Phe60Leu Single submitter ⚠
- p.Pro113Leu Single submitter ⚠
- p.Pro225Ser Single submitter ⚠
- p.Pro225Thr Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Ser125Leu Single submitter ⚠
- p.Ser135Asn Single submitter ⚠
- p.Ser158Asn Single submitter ⚠
- p.Ser163Leu Single submitter ⚠
- p.Ser178Leu Single submitter
- p.Ser222Asn Single submitter ⚠
- p.Ser252Arg Single submitter ⚠
- p.Ser252Asn Single submitter ⚠
- p.Thr49Ile Single submitter ⚠
- p.Val127Leu Single submitter ⚠
- p.Val159Ala Single submitter ⚠
- p.Val202Met Single submitter ⚠
- p.Val213Met Single submitter ⚠
- p.Val236Ile Single submitter ⚠
- p.Val263Met Single submitter ⚠
- p.Val305Ala Single submitter ⚠
- p.Val54Leu Single submitter ⚠
- p.Val74Ile Single submitter ⚠