SLC43A3 — 56 ClinVar variants
All ClinVar germline SLC43A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
1 Benign · 1 Likely benign · 54 Uncertain significance
Full SLC43A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC43A3 p.Ala254Val Uncertain significance Single submitter
- SLC43A3 p.Ala261Ser Uncertain significance Single submitter
- SLC43A3 p.Ala410Thr Uncertain significance Single submitter
- SLC43A3 p.Arg210Trp Uncertain significance Single submitter
- SLC43A3 p.Arg268His Uncertain significance Single submitter
- SLC43A3 p.Arg278Cys Uncertain significance Single submitter
- SLC43A3 p.Arg278His Uncertain significance Single submitter
- SLC43A3 p.Arg278Leu Uncertain significance Single submitter
- SLC43A3 p.Arg314Gln Uncertain significance Single submitter
- SLC43A3 p.Asn163Ser Uncertain significance Single submitter
- SLC43A3 p.Asn306Ser Uncertain significance Single submitter
- SLC43A3 p.Gln326Leu Uncertain significance Single submitter
- SLC43A3 p.Gln440Arg Uncertain significance Single submitter
- SLC43A3 p.Glu245Asp Uncertain significance Single submitter
- SLC43A3 p.Glu485Asp Uncertain significance Single submitter
- SLC43A3 p.Ile115Val Uncertain significance Single submitter
- SLC43A3 p.Ile135Thr Uncertain significance Single submitter
- SLC43A3 p.Leu126Pro Uncertain significance Single submitter
- SLC43A3 p.Leu217Pro Uncertain significance Single submitter
- SLC43A3 p.Leu374Val Uncertain significance Single submitter
- SLC43A3 p.Leu375Met Uncertain significance Single submitter
- SLC43A3 p.Leu393Phe Uncertain significance Single submitter
- SLC43A3 p.Lys236Thr Uncertain significance Single submitter
- SLC43A3 p.Lys484Glu Uncertain significance Single submitter
- SLC43A3 p.Met132Leu Uncertain significance Single submitter
- SLC43A3 p.Met132Val Uncertain significance Single submitter
- SLC43A3 p.Met339Leu Uncertain significance Single submitter
- SLC43A3 p.Met461Ile Uncertain significance Single submitter
- SLC43A3 p.Phe192Leu Uncertain significance Single submitter
- SLC43A3 p.Phe275Cys Uncertain significance Single submitter
- SLC43A3 p.Pro219Arg Uncertain significance Single submitter
- SLC43A3 p.Pro386Ser Uncertain significance Single submitter
- SLC43A3 p.Pro473Leu Uncertain significance Single submitter
- SLC43A3 p.Ser170Leu Uncertain significance Single submitter
- SLC43A3 p.Ser222Arg Uncertain significance Single submitter
- SLC43A3 p.Ser373Phe Uncertain significance Single submitter
- SLC43A3 p.Ser403Ala Uncertain significance Single submitter
- SLC43A3 p.Ser437Cys Uncertain significance Single submitter
- SLC43A3 p.Ser450Cys Uncertain significance Single submitter
- SLC43A3 p.Thr118Ser Uncertain significance Single submitter
- SLC43A3 p.Thr134Pro Uncertain significance Single submitter
- SLC43A3 p.Thr325Ala Uncertain significance Single submitter
- SLC43A3 p.Thr357Asn Uncertain significance Single submitter
- SLC43A3 p.Val284Met Uncertain significance Single submitter
- SLC43A3 p.Val476Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SLC43A3 p.Ala410Val Uncertain significance Single submitter
- SLC43A3 p.Arg203Cys Uncertain significance Single submitter
- SLC43A3 p.Arg481Cys Uncertain significance Single submitter
- SLC43A3 p.Ser269Phe Uncertain significance Single submitter
- SLC43A3 p.Tyr221Cys Uncertain significance Single submitter
- SLC43A3 p.Tyr223His Uncertain significance Single submitter
- SLC43A3 p.Tyr294Cys Uncertain significance Single submitter
All SLC43A3 variants
Benign 1
- c.361+3G>T Multiple submitters
Likely benign 1
- p.Ile135Val Single submitter
Uncertain significance 54
- p.Ala254Val Single submitter ⚠
- p.Ala261Ser Single submitter ⚠
- p.Ala410Thr Single submitter ⚠
- p.Ala410Val Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg210Trp Single submitter ⚠
- p.Arg268His Single submitter ⚠
- p.Arg278Cys Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg278Leu Single submitter ⚠
- p.Arg314Gln Single submitter ⚠
- p.Arg481Cys Single submitter ⚠
- p.Asn163Ser Single submitter ⚠
- p.Asn306Ser Single submitter ⚠
- p.Gln326Leu Single submitter ⚠
- p.Gln440Arg Single submitter ⚠
- p.Glu245Asp Single submitter ⚠
- p.Glu485Asp Single submitter ⚠
- p.Ile115Val Single submitter ⚠
- p.Ile135Thr Single submitter ⚠
- p.Ile297Thr Single submitter
- p.Leu126Pro Single submitter ⚠
- p.Leu217Pro Single submitter ⚠
- p.Leu374Val Single submitter ⚠
- p.Leu375Met Single submitter ⚠
- p.Leu393Phe Single submitter ⚠
- p.Leu425Phe Single submitter
- p.Lys236Thr Single submitter ⚠
- p.Lys484Glu Single submitter ⚠
- p.Met132Leu Single submitter ⚠
- p.Met132Val Single submitter ⚠
- p.Met339Leu Single submitter ⚠
- p.Met461Ile Single submitter ⚠
- p.Phe192Leu Single submitter ⚠
- p.Phe275Cys Single submitter ⚠
- p.Pro219Arg Single submitter ⚠
- p.Pro386Ser Single submitter ⚠
- p.Pro473Leu Single submitter ⚠
- p.Ser170Leu Single submitter ⚠
- p.Ser222Arg Single submitter ⚠
- p.Ser269Phe Single submitter ⚠
- p.Ser373Phe Single submitter ⚠
- p.Ser403Ala Single submitter ⚠
- p.Ser437Cys Single submitter ⚠
- p.Ser450Cys Single submitter ⚠
- p.Thr118Ser Single submitter ⚠
- p.Thr134Pro Single submitter ⚠
- p.Thr325Ala Single submitter ⚠
- p.Thr357Asn Single submitter ⚠
- p.Tyr221Cys Single submitter ⚠
- p.Tyr223His Single submitter ⚠
- p.Tyr294Cys Single submitter ⚠
- p.Val284Met Single submitter ⚠
- p.Val476Ile Single submitter ⚠