Sugi Variant

Sugi Variant/SLMAP

SLMAP — 673 ClinVar variants

All ClinVar germline SLMAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 314 flagged for review →

7 Conflicting · 38 Benign · 10 Benign/Likely benign · 265 Likely benign · 353 Uncertain significance

Full SLMAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 314

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 243

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 243

Predictors split 68

The independent predictors disagree with each other — read with care.

All SLMAP variants

Conflicting classifications of pathogenicity 7

Benign 38

Benign/Likely benign 10

  • p.Asp108= Multiple submitters Brugada syndrome
  • p.Asp592= Multiple submitters Brugada syndrome
  • p.Gln715= Multiple submitters Brugada syndrome
  • p.Glu439= Multiple submitters Brugada syndrome
  • p.Leu165= Multiple submitters Brugada syndrome
  • p.Leu217= Multiple submitters Brugada syndrome
  • p.Leu656= Multiple submitters Brugada syndrome
  • p.Ser641= Multiple submitters Brugada syndrome
  • p.Ser99= Multiple submitters Brugada syndrome
  • p.Thr688= Multiple submitters Brugada syndrome

Likely benign 265

Uncertain significance 353

Showing the top 300 by review status; the full set is in the sitemap.