SMOX — 59 ClinVar variants
All ClinVar germline SMOX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
3 Benign · 5 Likely benign · 51 Uncertain significance
Full SMOX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SMOX p.Ala11Val Uncertain significance Single submitter
- SMOX p.Ala247Val Uncertain significance Single submitter
- SMOX p.Ala252Asp Uncertain significance Single submitter
- SMOX p.Ala252Ser Uncertain significance Single submitter
- SMOX p.Ala325Val Uncertain significance Single submitter
- SMOX p.Ala510Val Uncertain significance Single submitter
- SMOX p.Arg129His Uncertain significance Single submitter
- SMOX p.Arg155Trp Uncertain significance Single submitter
- SMOX p.Arg20Gln Uncertain significance Single submitter
- SMOX p.Arg21Thr Uncertain significance Single submitter
- SMOX p.Arg281Gln Uncertain significance Single submitter
- SMOX p.Arg281Trp Uncertain significance Single submitter
- SMOX p.Arg359Ser Uncertain significance Single submitter
- SMOX p.Arg406His Uncertain significance Single submitter
- SMOX p.Arg453His Uncertain significance Single submitter
- SMOX p.Arg466Gln Uncertain significance Single submitter
- SMOX p.Arg523Cys Uncertain significance Single submitter
- SMOX p.Arg63His Uncertain significance Single submitter
- SMOX p.Asn161Ser Uncertain significance Single submitter
- SMOX p.Asp157Asn Uncertain significance Single submitter
- SMOX p.Asp285Asn Uncertain significance Single submitter
- SMOX p.Asp285His Uncertain significance Single submitter
- SMOX p.Gln454Arg Uncertain significance Single submitter
- SMOX p.Glu298Val Uncertain significance Single submitter
- SMOX p.Gly294Asp Uncertain significance Single submitter
- SMOX p.Gly302Arg Uncertain significance Single submitter
- SMOX p.Gly410Ser Uncertain significance Single submitter
- SMOX p.Gly536Ser Uncertain significance Single submitter
- SMOX p.Ile357Thr Uncertain significance Single submitter
- SMOX p.Ile544Thr Uncertain significance Single submitter
- SMOX p.Ser140Gly Uncertain significance Single submitter
- SMOX p.Ser218Thr Uncertain significance Single submitter
- SMOX p.Ser312Leu Uncertain significance Single submitter
- SMOX p.Ser470Leu Uncertain significance Single submitter
- SMOX p.Ser7Ile Uncertain significance Single submitter
- SMOX p.Thr190Ala Uncertain significance Single submitter
- SMOX p.Thr396Ala Uncertain significance Single submitter
- SMOX p.Tyr477Cys Uncertain significance Single submitter
- SMOX p.Val109Met Uncertain significance Single submitter
- SMOX p.Val120Met Uncertain significance Single submitter
- SMOX p.Val336Gly Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- SMOX p.Arg359His Uncertain significance Single submitter
- SMOX p.Arg479Cys Uncertain significance Single submitter
- SMOX p.Asp390Asn Uncertain significance Single submitter
- SMOX p.Gly128Ser Uncertain significance Single submitter
- SMOX p.His422Arg Uncertain significance Single submitter
- SMOX p.Leu76Val Uncertain significance Single submitter
- SMOX p.Pro476His Uncertain significance Single submitter
- SMOX p.Thr449Met Uncertain significance Single submitter
- SMOX p.Tyr123Cys Uncertain significance Single submitter
All SMOX variants
Likely benign 5
- p.Arg17= Single submitter
- p.Gly303Asp Single submitter
- p.His127Arg Single submitter
- p.Ile264Val Single submitter
- p.Ser333= Single submitter
Uncertain significance 51
- p.Ala11Val Single submitter ⚠
- p.Ala247Val Single submitter ⚠
- p.Ala252Asp Single submitter ⚠
- p.Ala252Ser Single submitter ⚠
- p.Ala325Val Single submitter ⚠
- p.Ala510Val Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg155Trp Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg21Thr Single submitter ⚠
- p.Arg281Gln Single submitter ⚠
- p.Arg281Trp Single submitter ⚠
- p.Arg359His Single submitter ⚠
- p.Arg359Ser Single submitter ⚠
- p.Arg406His Single submitter ⚠
- p.Arg453His Single submitter ⚠
- p.Arg466Gln Single submitter ⚠
- p.Arg479Cys Single submitter ⚠
- p.Arg523Cys Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Asn161Ser Single submitter ⚠
- p.Asp157Asn Single submitter ⚠
- p.Asp285Asn Single submitter ⚠
- p.Asp285His Single submitter ⚠
- p.Asp390Asn Single submitter ⚠
- p.Gln454Arg Single submitter ⚠
- p.Glu298Val Single submitter ⚠
- p.Gly128Ser Single submitter ⚠
- p.Gly294Asp Single submitter ⚠
- p.Gly302Arg Single submitter ⚠
- p.Gly410Ser Single submitter ⚠
- p.Gly536Ser Single submitter ⚠
- p.His422Arg Single submitter ⚠
- p.Ile357Thr Single submitter ⚠
- p.Ile544Thr Single submitter ⚠
- p.Leu322Pro Single submitter
- p.Leu76Val Single submitter ⚠
- p.Pro476His Single submitter ⚠
- p.Ser140Gly Single submitter ⚠
- p.Ser218Thr Single submitter ⚠
- p.Ser312Leu Single submitter ⚠
- p.Ser470Leu Single submitter ⚠
- p.Ser7Ile Single submitter ⚠
- p.Thr190Ala Single submitter ⚠
- p.Thr396Ala Single submitter ⚠
- p.Thr449Met Single submitter ⚠
- p.Tyr123Cys Single submitter ⚠
- p.Tyr477Cys Single submitter ⚠
- p.Val109Met Single submitter ⚠
- p.Val120Met Single submitter ⚠
- p.Val336Gly Single submitter ⚠