SNRK — 83 ClinVar variants
All ClinVar germline SNRK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
6 Benign · 5 Likely benign · 72 Uncertain significance
Full SNRK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SNRK p.Ala385Gly Uncertain significance Single submitter
- SNRK p.Ala385Val Uncertain significance Single submitter
- SNRK p.Arg403Gly Uncertain significance Single submitter
- SNRK p.Arg553Trp Uncertain significance Single submitter
- SNRK p.Arg624Cys Uncertain significance Single submitter
- SNRK p.Arg624His Uncertain significance Single submitter
- SNRK p.Arg625Cys Uncertain significance Single submitter
- SNRK p.Arg638Cys Uncertain significance Single submitter
- SNRK p.Arg720Gln Uncertain significance Single submitter
- SNRK p.Arg77His Uncertain significance Single submitter
- SNRK p.Asn588Ser Uncertain significance Single submitter
- SNRK p.Asn615His Uncertain significance Single submitter
- SNRK p.Asn728Ser Uncertain significance Single submitter
- SNRK p.Asn743Asp Uncertain significance Single submitter
- SNRK p.Asp114His Uncertain significance Single submitter
- SNRK p.Asp372Val Uncertain significance Single submitter
- SNRK p.Asp414Gly Uncertain significance Single submitter
- SNRK p.Gln488Glu Uncertain significance Single submitter
- SNRK p.Gln657His Uncertain significance Single submitter
- SNRK p.Glu642Lys Uncertain significance Single submitter
- SNRK p.Glu719Lys Uncertain significance Single submitter
- SNRK p.Gly605Ala Uncertain significance Single submitter
- SNRK p.Gly611Ser Uncertain significance Single submitter
- SNRK p.Gly655Ser Uncertain significance Single submitter
- SNRK p.Gly671Val Uncertain significance Single submitter
- SNRK p.His523Pro Uncertain significance Single submitter
- SNRK p.His710Arg Uncertain significance Single submitter
- SNRK p.Ile104Thr Uncertain significance Single submitter
- SNRK p.Ile666Thr Uncertain significance Single submitter
- SNRK p.Ile740Val Uncertain significance Single submitter
- SNRK p.Leu260Ser Uncertain significance Single submitter
- SNRK p.Leu424His Uncertain significance Single submitter
- SNRK p.Leu424Phe Uncertain significance Single submitter
- SNRK p.Leu467Val Uncertain significance Single submitter
- SNRK p.Leu726Met Uncertain significance Single submitter
- SNRK p.Leu753Met Uncertain significance Single submitter
- SNRK p.Lys724Arg Uncertain significance Single submitter
- SNRK p.Met226Val Uncertain significance Single submitter
- SNRK p.Met633Val Uncertain significance Single submitter
- SNRK p.Met650Val Uncertain significance Single submitter
- SNRK p.Phe707Leu Uncertain significance Single submitter
- SNRK p.Pro699His Uncertain significance Single submitter
- SNRK p.Ser607Gly Uncertain significance Single submitter
- SNRK p.Ser656Ala Uncertain significance Single submitter
- SNRK p.Ser676Arg Uncertain significance Single submitter
- SNRK p.Ser723Asn Uncertain significance Single submitter
- SNRK p.Ser757Thr Uncertain significance Single submitter
- SNRK p.Thr378Arg Uncertain significance Single submitter
- SNRK p.Thr380Ser Uncertain significance Single submitter
- SNRK p.Thr426Met Uncertain significance Single submitter
- SNRK p.Thr54Ala Uncertain significance Single submitter
- SNRK p.Thr684Met Uncertain significance Single submitter
- SNRK p.Tyr280Cys Uncertain significance Single submitter
- SNRK p.Val485Ile Uncertain significance Single submitter
- SNRK p.Gly582Asp Uncertain significance No assertion criteria
Predictors split 13
The independent predictors disagree with each other — read with care.
- SNRK p.Arg252Lys Uncertain significance Single submitter
- SNRK p.Arg301Cys Uncertain significance Single submitter
- SNRK p.Arg310Gly Uncertain significance Single submitter
- SNRK p.Arg525Cys Uncertain significance Single submitter
- SNRK p.Arg534Trp Uncertain significance Single submitter
- SNRK p.Asp19Gly Uncertain significance Single submitter
- SNRK p.Cys688Ser Uncertain significance Single submitter
- SNRK p.Glu737Lys Uncertain significance Single submitter
- SNRK p.Leu187Ile Uncertain significance Single submitter
- SNRK p.Lys243Glu Uncertain significance Single submitter
- SNRK p.Lys41Asn Uncertain significance Single submitter
- SNRK p.Pro213Leu Uncertain significance Single submitter
- SNRK p.Val76Ile Uncertain significance Single submitter
All SNRK variants
Benign 6
Likely benign 5
- p.Ala627= Single submitter
- p.Glu645Gln Single submitter
- p.Gly703Ser Single submitter
- p.Ser610Gly Single submitter
- p.Ser661Gly Single submitter
Uncertain significance 72
- p.Ala385Gly Single submitter ⚠
- p.Ala385Val Single submitter ⚠
- p.Arg252Lys Single submitter ⚠
- p.Arg301Cys Single submitter ⚠
- p.Arg310Gly Single submitter ⚠
- p.Arg403Gly Single submitter ⚠
- p.Arg525Cys Single submitter ⚠
- p.Arg528Gln Single submitter
- p.Arg534Trp Single submitter ⚠
- p.Arg553Trp Single submitter ⚠
- p.Arg624Cys Single submitter ⚠
- p.Arg624His Single submitter ⚠
- p.Arg625Cys Single submitter ⚠
- p.Arg638Cys Single submitter ⚠
- p.Arg720Gln Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Asn588Ser Single submitter ⚠
- p.Asn615His Single submitter ⚠
- p.Asn728Ser Single submitter ⚠
- p.Asn743Asp Single submitter ⚠
- p.Asp114His Single submitter ⚠
- p.Asp19Gly Single submitter ⚠
- p.Asp372Val Single submitter ⚠
- p.Asp414Gly Single submitter ⚠
- p.Cys626Trp Single submitter
- p.Cys688Ser Single submitter ⚠
- p.Gln488Glu Single submitter ⚠
- p.Gln657His Single submitter ⚠
- p.Gln732Pro Single submitter
- p.Glu642Lys Single submitter ⚠
- p.Glu719Lys Single submitter ⚠
- p.Glu737Lys Single submitter ⚠
- p.Gly605Ala Single submitter ⚠
- p.Gly611Ser Single submitter ⚠
- p.Gly655Ser Single submitter ⚠
- p.Gly671Val Single submitter ⚠
- p.His523Pro Single submitter ⚠
- p.His710Arg Single submitter ⚠
- p.Ile104Thr Single submitter ⚠
- p.Ile666Thr Single submitter ⚠
- p.Ile740Val Single submitter ⚠
- p.Leu187Ile Single submitter ⚠
- p.Leu260Ser Single submitter ⚠
- p.Leu424His Single submitter ⚠
- p.Leu424Phe Single submitter ⚠
- p.Leu467Trp Single submitter
- p.Leu467Val Single submitter ⚠
- p.Leu726Met Single submitter ⚠
- p.Leu753Met Single submitter ⚠
- p.Lys243Glu Single submitter ⚠
- p.Lys41Asn Single submitter ⚠
- p.Lys724Arg Single submitter ⚠
- p.Met226Val Single submitter ⚠
- p.Met633Val Single submitter ⚠
- p.Met650Val Single submitter ⚠
- p.Phe707Leu Single submitter ⚠
- p.Pro213Leu Single submitter ⚠
- p.Pro699His Single submitter ⚠
- p.Ser607Gly Single submitter ⚠
- p.Ser656Ala Single submitter ⚠
- p.Ser676Arg Single submitter ⚠
- p.Ser723Asn Single submitter ⚠
- p.Ser757Thr Single submitter ⚠
- p.Thr378Arg Single submitter ⚠
- p.Thr380Ser Single submitter ⚠
- p.Thr426Met Single submitter ⚠
- p.Thr54Ala Single submitter ⚠
- p.Thr684Met Single submitter ⚠
- p.Tyr280Cys Single submitter ⚠
- p.Val485Ile Single submitter ⚠
- p.Val76Ile Single submitter ⚠
- p.Gly582Asp No assertion criteria ⚠