SPATS2L — 86 ClinVar variants
All ClinVar germline SPATS2L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
2 Likely benign · 84 Uncertain significance
Full SPATS2L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 73
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SPATS2L p.Ala16Thr Uncertain significance Single submitter
- SPATS2L p.Ala203Thr Uncertain significance Single submitter
- SPATS2L p.Ala214Gly Uncertain significance Single submitter
- SPATS2L p.Ala334Thr Uncertain significance Single submitter
- SPATS2L p.Ala402Thr Uncertain significance Single submitter
- SPATS2L p.Ala415Ser Uncertain significance Single submitter
- SPATS2L p.Ala424Asp Uncertain significance Single submitter
- SPATS2L p.Ala501Ser Uncertain significance Single submitter
- SPATS2L p.Ala514Thr Uncertain significance Single submitter
- SPATS2L p.Ala546Gly Uncertain significance Single submitter
- SPATS2L p.Arg130Cys Uncertain significance Single submitter
- SPATS2L p.Arg173Thr Uncertain significance Single submitter
- SPATS2L p.Arg239His Uncertain significance Single submitter
- SPATS2L p.Arg289Cys Uncertain significance Single submitter
- SPATS2L p.Arg336Gly Uncertain significance Single submitter
- SPATS2L p.Arg468Cys Uncertain significance Single submitter
- SPATS2L p.Arg510Gln Uncertain significance Single submitter
- SPATS2L p.Arg524Gly Uncertain significance Single submitter
- SPATS2L p.Arg90Met Uncertain significance Single submitter
- SPATS2L p.Asn151Thr Uncertain significance Single submitter
- SPATS2L p.Asn200Ser Uncertain significance Single submitter
- SPATS2L p.Asn23Tyr Uncertain significance Single submitter
- SPATS2L p.Asn262Ser Uncertain significance Single submitter
- SPATS2L p.Asn425Ser Uncertain significance Single submitter
- SPATS2L p.Asn477Ser Uncertain significance Single submitter
- SPATS2L p.Asp119Gly Uncertain significance Single submitter
- SPATS2L p.Asp161Val Uncertain significance Single submitter
- SPATS2L p.Asp516Glu Uncertain significance Single submitter
- SPATS2L p.Gln178Lys Uncertain significance Single submitter
- SPATS2L p.Gln347Arg Uncertain significance Single submitter
- SPATS2L p.Glu112Asp Uncertain significance Single submitter
- SPATS2L p.Glu182Ala Uncertain significance Single submitter
- SPATS2L p.Glu313Lys Uncertain significance Single submitter
- SPATS2L p.Glu500Lys Uncertain significance Single submitter
- SPATS2L p.Gly382Glu Uncertain significance Single submitter
- SPATS2L p.Gly429Ala Uncertain significance Single submitter
- SPATS2L p.Gly478Ser Uncertain significance Single submitter
- SPATS2L p.Gly528Asp Uncertain significance Single submitter
- SPATS2L p.His469Asn Uncertain significance Single submitter
- SPATS2L p.His476Tyr Uncertain significance Single submitter
- SPATS2L p.Ile136Thr Uncertain significance Single submitter
- SPATS2L p.Ile540Thr Uncertain significance Single submitter
- SPATS2L p.Lys165Arg Uncertain significance Single submitter
- SPATS2L p.Lys345Glu Uncertain significance Single submitter
- SPATS2L p.Lys488Arg Uncertain significance Single submitter
- SPATS2L p.Met309Leu Uncertain significance Single submitter
- SPATS2L p.Met349Leu Uncertain significance Single submitter
- SPATS2L p.Pro129Leu Uncertain significance Single submitter
- SPATS2L p.Pro140Ser Uncertain significance Single submitter
- SPATS2L p.Pro166Ser Uncertain significance Single submitter
- SPATS2L p.Pro184His Uncertain significance Single submitter
- SPATS2L p.Pro187Leu Uncertain significance Single submitter
- SPATS2L p.Pro405Arg Uncertain significance Single submitter
- SPATS2L p.Pro417Leu Uncertain significance Single submitter
- SPATS2L p.Pro475Leu Uncertain significance Single submitter
- SPATS2L p.Pro475Ser Uncertain significance Single submitter
- SPATS2L p.Pro499Ala Uncertain significance Single submitter
- SPATS2L p.Pro502Gln Uncertain significance Single submitter
- SPATS2L p.Pro502Leu Uncertain significance Single submitter
- SPATS2L p.Pro502Thr Uncertain significance Single submitter
- SPATS2L p.Pro508Leu Uncertain significance Single submitter
- SPATS2L p.Pro91Arg Uncertain significance Single submitter
- SPATS2L p.Pro98Leu Uncertain significance Single submitter
- SPATS2L p.Ser115Arg Uncertain significance Single submitter
- SPATS2L p.Ser270Leu Uncertain significance Single submitter
- SPATS2L p.Ser418Cys Uncertain significance Single submitter
- SPATS2L p.Ser518Leu Uncertain significance Single submitter
- SPATS2L p.Thr170Pro Uncertain significance Single submitter
- SPATS2L p.Thr498Asn Uncertain significance Single submitter
- SPATS2L p.Trp59Arg Uncertain significance Single submitter
- SPATS2L p.Val147Ile Uncertain significance Single submitter
- SPATS2L p.Val240Ile Uncertain significance Single submitter
- SPATS2L p.Val88Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- SPATS2L p.Ala335Val Uncertain significance Single submitter
- SPATS2L p.Arg435Gln Uncertain significance Single submitter
- SPATS2L p.Arg435Trp Uncertain significance Single submitter
- SPATS2L p.Asn23Lys Uncertain significance Single submitter
- SPATS2L p.Asn428Lys Uncertain significance Single submitter
- SPATS2L p.Asn68Asp Uncertain significance Single submitter
- SPATS2L p.Glu470Lys Uncertain significance Single submitter
- SPATS2L p.Ile285Val Uncertain significance Single submitter
- SPATS2L p.Tyr327His Uncertain significance Single submitter
- SPATS2L p.Val250Leu Uncertain significance Single submitter
All SPATS2L variants
Likely benign 2
- p.Gly150Asp Single submitter
- p.Leu137Pro Single submitter
Uncertain significance 84
- p.Ala16Thr Single submitter ⚠
- p.Ala203Thr Single submitter ⚠
- p.Ala214Gly Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala335Val Single submitter ⚠
- p.Ala402Thr Single submitter ⚠
- p.Ala415Ser Single submitter ⚠
- p.Ala424Asp Single submitter ⚠
- p.Ala501Ser Single submitter ⚠
- p.Ala514Thr Single submitter ⚠
- p.Ala546Gly Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg173Thr Single submitter ⚠
- p.Arg239His Single submitter ⚠
- p.Arg289Cys Single submitter ⚠
- p.Arg336Gly Single submitter ⚠
- p.Arg435Gln Single submitter ⚠
- p.Arg435Trp Single submitter ⚠
- p.Arg468Cys Single submitter ⚠
- p.Arg510Gln Single submitter ⚠
- p.Arg524Gly Single submitter ⚠
- p.Arg90Met Single submitter ⚠
- p.Asn151Thr Single submitter ⚠
- p.Asn200Ser Single submitter ⚠
- p.Asn23Lys Single submitter ⚠
- p.Asn23Tyr Single submitter ⚠
- p.Asn262Ser Single submitter ⚠
- p.Asn425Ser Single submitter ⚠
- p.Asn428Lys Single submitter ⚠
- p.Asn477Ser Single submitter ⚠
- p.Asn68Asp Single submitter ⚠
- p.Asp119Gly Single submitter ⚠
- p.Asp161Val Single submitter ⚠
- p.Asp516Glu Single submitter ⚠
- p.Gln178Lys Single submitter ⚠
- p.Gln347Arg Single submitter ⚠
- p.Glu112Asp Single submitter ⚠
- p.Glu182Ala Single submitter ⚠
- p.Glu313Lys Single submitter ⚠
- p.Glu470Lys Single submitter ⚠
- p.Glu500Lys Single submitter ⚠
- p.Gly382Glu Single submitter ⚠
- p.Gly429Ala Single submitter ⚠
- p.Gly478Ser Single submitter ⚠
- p.Gly528Asp Single submitter ⚠
- p.His469Asn Single submitter ⚠
- p.His476Tyr Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile285Val Single submitter ⚠
- p.Ile540Thr Single submitter ⚠
- p.Lys165Arg Single submitter ⚠
- p.Lys345Glu Single submitter ⚠
- p.Lys488Arg Single submitter ⚠
- p.Met309Leu Single submitter ⚠
- p.Met349Leu Single submitter ⚠
- p.Pro129Leu Single submitter ⚠
- p.Pro140Ser Single submitter ⚠
- p.Pro166Ser Single submitter ⚠
- p.Pro184His Single submitter ⚠
- p.Pro187Leu Single submitter ⚠
- p.Pro405Arg Single submitter ⚠
- p.Pro417Leu Single submitter ⚠
- p.Pro475Leu Single submitter ⚠
- p.Pro475Ser Single submitter ⚠
- p.Pro499Ala Single submitter ⚠
- p.Pro502Gln Single submitter ⚠
- p.Pro502Leu Single submitter ⚠
- p.Pro502Thr Single submitter ⚠
- p.Pro508Leu Single submitter ⚠
- p.Pro91Arg Single submitter ⚠
- p.Pro98Leu Single submitter ⚠
- p.Ser115Arg Single submitter ⚠
- p.Ser270Leu Single submitter ⚠
- p.Ser418Cys Single submitter ⚠
- p.Ser518Leu Single submitter ⚠
- p.Thr170Pro Single submitter ⚠
- p.Thr498Asn Single submitter ⚠
- p.Trp59Arg Single submitter ⚠
- p.Tyr327His Single submitter ⚠
- p.Val147Ile Single submitter ⚠
- p.Val240Ile Single submitter ⚠
- p.Val250Leu Single submitter ⚠
- p.Val250Met Single submitter
- p.Val88Leu Single submitter ⚠