SPIN1 — 9 ClinVar variants
All ClinVar germline SPIN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
9 Uncertain significance
Full SPIN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All SPIN1 variants
Uncertain significance 9
- p.Ala119Val Single submitter ⚠
- p.Ala126Ser Single submitter ⚠
- p.Arg117Gly Single submitter ⚠
- p.Arg37Trp Single submitter ⚠
- p.Asn163Ser Single submitter ⚠
- p.Asp198Tyr Single submitter ⚠
- p.His127Arg Single submitter ⚠
- p.Pro194Ser Single submitter
- p.Val82Leu Single submitter ⚠