SSTR1 — 55 ClinVar variants
All ClinVar germline SSTR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Benign · 1 Likely benign · 53 Uncertain significance
Full SSTR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SSTR1 p.Ala297Val Uncertain significance Single submitter
- SSTR1 p.Ala357Gly Uncertain significance Single submitter
- SSTR1 p.Arg380His Uncertain significance Single submitter
- SSTR1 p.Arg380Pro Uncertain significance Single submitter
- SSTR1 p.Asn345Asp Uncertain significance Single submitter
- SSTR1 p.Asn345Ser Uncertain significance Single submitter
- SSTR1 p.Asn4Ser Uncertain significance Single submitter
- SSTR1 p.Cys21Gly Uncertain significance Single submitter
- SSTR1 p.Cys69Arg Uncertain significance Single submitter
- SSTR1 p.Gly19Asp Uncertain significance Single submitter
- SSTR1 p.Gly24Arg Uncertain significance Single submitter
- SSTR1 p.Gly29Asp Uncertain significance Single submitter
- SSTR1 p.Gly33Ala Uncertain significance Single submitter
- SSTR1 p.Gly376Arg Uncertain significance Single submitter
- SSTR1 p.Gly376Ser Uncertain significance Single submitter
- SSTR1 p.Gly54Ser Uncertain significance Single submitter
- SSTR1 p.Ile246Met Uncertain significance Single submitter
- SSTR1 p.Ile388Ser Uncertain significance Single submitter
- SSTR1 p.Leu151Pro Uncertain significance Single submitter
- SSTR1 p.Leu190Met Uncertain significance Single submitter
- SSTR1 p.Leu255Val Uncertain significance Single submitter
- SSTR1 p.Leu326Val Uncertain significance Single submitter
- SSTR1 p.Leu373Arg Uncertain significance Single submitter
- SSTR1 p.Leu73Val Uncertain significance Single submitter
- SSTR1 p.Lys164Arg Uncertain significance Single submitter
- SSTR1 p.Met230Val Uncertain significance Single submitter
- SSTR1 p.Met78Val Uncertain significance Single submitter
- SSTR1 p.Pro350Ser Uncertain significance Single submitter
- SSTR1 p.Ser15Gly Uncertain significance Single submitter
- SSTR1 p.Ser364Asn Uncertain significance Single submitter
- SSTR1 p.Ser8Cys Uncertain significance Single submitter
- SSTR1 p.Val153Leu Uncertain significance Single submitter
- SSTR1 p.Val157Leu Uncertain significance Single submitter
- SSTR1 p.Val351Ala Uncertain significance Single submitter
- SSTR1 p.Val68Glu Uncertain significance Single submitter
- SSTR1 p.Val82Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- SSTR1 p.Arg264Cys Uncertain significance Single submitter
- SSTR1 p.Arg264Gly Uncertain significance Single submitter
- SSTR1 p.Arg336Ser Uncertain significance Single submitter
- SSTR1 p.Arg85Cys Uncertain significance Single submitter
- SSTR1 p.Asn48Lys Uncertain significance Single submitter
- SSTR1 p.Met230Arg Uncertain significance Single submitter
- SSTR1 p.Met250Thr Uncertain significance Single submitter
- SSTR1 p.Met285Ile Uncertain significance Single submitter
- SSTR1 p.Phe325Cys Uncertain significance Single submitter
- SSTR1 p.Phe63Leu Uncertain significance Single submitter
- SSTR1 p.Val181Leu Uncertain significance Single submitter
All SSTR1 variants
Benign 1
- p.Val136= Multiple submitters
Likely benign 1
- p.Tyr81= Single submitter
Uncertain significance 53
- p.Ala297Val Single submitter ⚠
- p.Ala357Gly Single submitter ⚠
- p.Arg264Cys Single submitter ⚠
- p.Arg264Gly Single submitter ⚠
- p.Arg336Ser Single submitter ⚠
- p.Arg380His Single submitter ⚠
- p.Arg380Pro Single submitter ⚠
- p.Arg387Gly Single submitter
- p.Arg85Cys Single submitter ⚠
- p.Asn345Asp Single submitter ⚠
- p.Asn345Ser Single submitter ⚠
- p.Asn48Lys Single submitter ⚠
- p.Asn4Ser Single submitter ⚠
- p.Asn94del Single submitter
- p.Cys21Gly Single submitter ⚠
- p.Cys69Arg Single submitter ⚠
- p.Gly19Asp Single submitter ⚠
- p.Gly204Asp Single submitter
- p.Gly24Arg Single submitter ⚠
- p.Gly29Asp Single submitter ⚠
- p.Gly33Ala Single submitter ⚠
- p.Gly376Arg Single submitter ⚠
- p.Gly376Ser Single submitter ⚠
- p.Gly54Ser Single submitter ⚠
- p.Ile246Met Single submitter ⚠
- p.Ile388Ser Single submitter ⚠
- p.Leu151Pro Single submitter ⚠
- p.Leu190Met Single submitter ⚠
- p.Leu255Val Single submitter ⚠
- p.Leu326Val Single submitter ⚠
- p.Leu373Arg Single submitter ⚠
- p.Leu73Val Single submitter ⚠
- p.Lys164Arg Single submitter ⚠
- p.Met230Arg Single submitter ⚠
- p.Met230Val Single submitter ⚠
- p.Met250Thr Single submitter ⚠
- p.Met285Ile Single submitter ⚠
- p.Met78Val Single submitter ⚠
- p.Phe325Cys Single submitter ⚠
- p.Phe63Leu Single submitter ⚠
- p.Pro350Ser Single submitter ⚠
- p.Ser15Gly Single submitter ⚠
- p.Ser364Asn Single submitter ⚠
- p.Ser8Cys Single submitter ⚠
- p.Thr143Ser Single submitter
- p.Tyr86His Single submitter
- p.Val153Leu Single submitter ⚠
- p.Val157Leu Single submitter ⚠
- p.Val181Leu Single submitter ⚠
- p.Val236fs Single submitter
- p.Val351Ala Single submitter ⚠
- p.Val68Glu Single submitter ⚠
- p.Val82Leu Single submitter ⚠