ST3GAL1 — 43 ClinVar variants
All ClinVar germline ST3GAL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
3 Benign · 1 Benign/Likely benign · 2 Likely benign · 37 Uncertain significance
Full ST3GAL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ST3GAL1 p.Arg5Leu Uncertain significance Single submitter
- ST3GAL1 p.Arg5Trp Uncertain significance Single submitter
- ST3GAL1 p.Arg7Ser Uncertain significance Single submitter
- ST3GAL1 p.Asn201Asp Uncertain significance Single submitter
- ST3GAL1 p.Asp317Asn Uncertain significance Single submitter
- ST3GAL1 p.Asp95Val Uncertain significance Single submitter
- ST3GAL1 p.Gly199Arg Uncertain significance Single submitter
- ST3GAL1 p.Gly288Cys Uncertain significance Single submitter
- ST3GAL1 p.Gly339Arg Uncertain significance Single submitter
- ST3GAL1 p.Ile19Thr Uncertain significance Single submitter
- ST3GAL1 p.Leu26Arg Uncertain significance Single submitter
- ST3GAL1 p.Lys6Glu Uncertain significance Single submitter
- ST3GAL1 p.Met204Val Uncertain significance Single submitter
- ST3GAL1 p.Met32Val Uncertain significance Single submitter
- ST3GAL1 p.Met42Val Uncertain significance Single submitter
- ST3GAL1 p.Met82Thr Uncertain significance Single submitter
- ST3GAL1 p.Phe337Cys Uncertain significance Single submitter
- ST3GAL1 p.Pro305Leu Uncertain significance Single submitter
- ST3GAL1 p.Ser155Ala Uncertain significance Single submitter
- ST3GAL1 p.Thr116Ile Uncertain significance Single submitter
- ST3GAL1 p.Thr222Ile Uncertain significance Single submitter
- ST3GAL1 p.Thr225Ser Uncertain significance Single submitter
- ST3GAL1 p.Thr325Met Uncertain significance Single submitter
- ST3GAL1 p.Thr62Ile Uncertain significance Single submitter
- ST3GAL1 p.Val128Ala Uncertain significance Single submitter
- ST3GAL1 p.Val16Leu Uncertain significance Single submitter
- ST3GAL1 p.Val16Met Uncertain significance Single submitter
- ST3GAL1 p.Val2Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ST3GAL1 p.Ala307Thr Uncertain significance Single submitter
- ST3GAL1 p.Arg140Trp Uncertain significance Single submitter
- ST3GAL1 p.Arg335Trp Uncertain significance Single submitter
- ST3GAL1 p.Gly126Glu Uncertain significance Single submitter
- ST3GAL1 p.His298Asn Uncertain significance Single submitter
- ST3GAL1 p.Phe276Leu Uncertain significance Single submitter
- ST3GAL1 p.Tyr156Cys Uncertain significance Single submitter
- ST3GAL1 p.Val324Met Uncertain significance Single submitter
All ST3GAL1 variants
Benign 3
- p.Ala91Thr Multiple submitters
- p.Cys64= Multiple submitters
- p.Ser154= Multiple submitters
Benign/Likely benign 1
- c.684-8A>G Multiple submitters
Likely benign 2
- p.Ile65Val Single submitter
- p.Met278Leu Single submitter
Uncertain significance 37
- p.Ala307Thr Single submitter ⚠
- p.Arg140Trp Single submitter ⚠
- p.Arg335Trp Single submitter ⚠
- p.Arg5Leu Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Arg7Ser Single submitter ⚠
- p.Asn201Asp Single submitter ⚠
- p.Asp317Asn Single submitter ⚠
- p.Asp95Val Single submitter ⚠
- p.Gly126Glu Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly288Cys Single submitter ⚠
- p.Gly339Arg Single submitter ⚠
- p.His298Asn Single submitter ⚠
- p.Ile19Thr Single submitter ⚠
- p.Leu26Arg Single submitter ⚠
- p.Lys6Glu Single submitter ⚠
- p.Met204Val Single submitter ⚠
- p.Met32Val Single submitter ⚠
- p.Met42Val Single submitter ⚠
- p.Met82Thr Single submitter ⚠
- p.Phe276Leu Single submitter ⚠
- p.Phe337Cys Single submitter ⚠
- p.Pro305Leu Single submitter ⚠
- p.Pro84Leu Single submitter
- p.Ser155Ala Single submitter ⚠
- p.Thr116Ile Single submitter ⚠
- p.Thr222Ile Single submitter ⚠
- p.Thr225Ser Single submitter ⚠
- p.Thr325Met Single submitter ⚠
- p.Thr62Ile Single submitter ⚠
- p.Tyr156Cys Single submitter ⚠
- p.Val128Ala Single submitter ⚠
- p.Val16Leu Single submitter ⚠
- p.Val16Met Single submitter ⚠
- p.Val2Met Single submitter ⚠
- p.Val324Met Single submitter ⚠