STIP1 — 51 ClinVar variants
All ClinVar germline STIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Benign · 1 Benign/Likely benign · 2 Likely benign · 47 Uncertain significance
Full STIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STIP1 p.Ala266Thr Uncertain significance Single submitter
- STIP1 p.Arg351Gln Uncertain significance Single submitter
- STIP1 p.Asn276Asp Uncertain significance Single submitter
- STIP1 p.Asn276Ser Uncertain significance Single submitter
- STIP1 p.Asp443Gly Uncertain significance Single submitter
- STIP1 p.Asp66Asn Uncertain significance Single submitter
- STIP1 p.Cys370Trp Uncertain significance Single submitter
- STIP1 p.Glu116Lys Uncertain significance Single submitter
- STIP1 p.Glu271Gly Uncertain significance Single submitter
- STIP1 p.Glu6Lys Uncertain significance Single submitter
- STIP1 p.Ile31Val Uncertain significance Single submitter
- STIP1 p.Leu361Met Uncertain significance Single submitter
- STIP1 p.Leu455Val Uncertain significance Single submitter
- STIP1 p.Lys13Arg Uncertain significance Single submitter
- STIP1 p.Lys246Gln Uncertain significance Single submitter
- STIP1 p.Lys513Arg Uncertain significance Single submitter
- STIP1 p.Lys523Arg Uncertain significance Single submitter
- STIP1 p.Met115Val Uncertain significance Single submitter
- STIP1 p.Phe124Cys Uncertain significance Single submitter
- STIP1 p.Pro204Ser Uncertain significance Single submitter
- STIP1 p.Ser459Pro Uncertain significance Single submitter
- STIP1 p.Thr168Ser Uncertain significance Single submitter
- STIP1 p.Thr445Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- STIP1 p.Ala386Gly Uncertain significance Single submitter
- STIP1 p.Ala474Glu Uncertain significance Single submitter
- STIP1 p.Arg174Gln Uncertain significance Single submitter
- STIP1 p.Arg174Trp Uncertain significance Single submitter
- STIP1 p.Arg470His Uncertain significance Single submitter
- STIP1 p.Asp480Asn Uncertain significance Single submitter
- STIP1 p.Asp492Asn Uncertain significance Single submitter
- STIP1 p.Glu280Gln Uncertain significance Single submitter
- STIP1 p.Glu29Lys Uncertain significance Single submitter
- STIP1 p.Glu463Asp Uncertain significance Single submitter
- STIP1 p.Leu182Phe Uncertain significance Single submitter
- STIP1 p.Lys373Asn Uncertain significance Single submitter
- STIP1 p.Met214Val Uncertain significance Single submitter
- STIP1 p.Met499Val Uncertain significance Single submitter
- STIP1 p.Phe88Leu Uncertain significance Single submitter
- STIP1 p.Pro127Leu Uncertain significance Single submitter
- STIP1 p.Pro256Leu Uncertain significance Single submitter
- STIP1 p.Thr260Ala Uncertain significance Single submitter
- STIP1 p.Thr260Ile Uncertain significance Single submitter
- STIP1 p.Thr405Ile Uncertain significance Single submitter
- STIP1 p.Tyr303Cys Uncertain significance Single submitter
- STIP1 p.Tyr310Cys Uncertain significance Single submitter
All STIP1 variants
Benign 1
- p.Ile20= Single submitter
Benign/Likely benign 1
- p.Tyr27= Multiple submitters
Likely benign 2
- p.Ser28= Single submitter
- p.Ser460Asn Single submitter
Uncertain significance 47
- p.Ala266Thr Single submitter ⚠
- p.Ala386Gly Single submitter ⚠
- p.Ala474Glu Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg174Trp Single submitter ⚠
- p.Arg351Gln Single submitter ⚠
- p.Arg470His Single submitter ⚠
- p.Asn276Asp Single submitter ⚠
- p.Asn276Ser Single submitter ⚠
- p.Asn324Tyr Single submitter
- p.Asp443Gly Single submitter ⚠
- p.Asp480Asn Single submitter ⚠
- p.Asp492Asn Single submitter ⚠
- p.Asp66Asn Single submitter ⚠
- p.Asp70Val Single submitter
- p.Cys370Trp Single submitter ⚠
- p.Glu116Lys Single submitter ⚠
- p.Glu271Gly Single submitter ⚠
- p.Glu280Gln Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Glu463Asp Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Ile31Val Single submitter ⚠
- p.Leu182Phe Single submitter ⚠
- p.Leu361Met Single submitter ⚠
- p.Leu455Val Single submitter ⚠
- p.Lys13Arg Single submitter ⚠
- p.Lys246Gln Single submitter ⚠
- p.Lys373Asn Single submitter ⚠
- p.Lys513Arg Single submitter ⚠
- p.Lys523Arg Single submitter ⚠
- p.Met115Val Single submitter ⚠
- p.Met214Val Single submitter ⚠
- p.Met499Val Single submitter ⚠
- p.Phe124Cys Single submitter ⚠
- p.Phe88Leu Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro204Ser Single submitter ⚠
- p.Pro256Leu Single submitter ⚠
- p.Ser459Pro Single submitter ⚠
- p.Thr168Ser Single submitter ⚠
- p.Thr260Ala Single submitter ⚠
- p.Thr260Ile Single submitter ⚠
- p.Thr405Ile Single submitter ⚠
- p.Thr445Ile Single submitter ⚠
- p.Tyr303Cys Single submitter ⚠
- p.Tyr310Cys Single submitter ⚠