STK32C — 68 ClinVar variants
All ClinVar germline STK32C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
6 Benign · 4 Likely benign · 58 Uncertain significance
Full STK32C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK32C p.Ala24Thr Uncertain significance Single submitter
- STK32C p.Ala27Gly Uncertain significance Single submitter
- STK32C p.Ala468Val Uncertain significance Single submitter
- STK32C p.Ala472Thr Uncertain significance Single submitter
- STK32C p.Arg113Gln Uncertain significance Single submitter
- STK32C p.Arg113Trp Uncertain significance Single submitter
- STK32C p.Arg140Gln Uncertain significance Single submitter
- STK32C p.Arg330Gln Uncertain significance Single submitter
- STK32C p.Arg340Gln Uncertain significance Single submitter
- STK32C p.Arg449Lys Uncertain significance Single submitter
- STK32C p.Arg470Cys Uncertain significance Single submitter
- STK32C p.Asn301Lys Uncertain significance Single submitter
- STK32C p.Gln60His Uncertain significance Single submitter
- STK32C p.Gln94Glu Uncertain significance Single submitter
- STK32C p.Glu462Gly Uncertain significance Single submitter
- STK32C p.Gly369Ser Uncertain significance Single submitter
- STK32C p.Gly477Val Uncertain significance Single submitter
- STK32C p.His339Tyr Uncertain significance Single submitter
- STK32C p.Ile130Val Uncertain significance Single submitter
- STK32C p.Ile213Leu Uncertain significance Single submitter
- STK32C p.Ile261Val Uncertain significance Single submitter
- STK32C p.Leu357Pro Uncertain significance Single submitter
- STK32C p.Lys254Arg Uncertain significance Single submitter
- STK32C p.Met118Ile Uncertain significance Single submitter
- STK32C p.Met124Val Uncertain significance Single submitter
- STK32C p.Met475Thr Uncertain significance Single submitter
- STK32C p.Met475Val Uncertain significance Single submitter
- STK32C p.Met72Thr Uncertain significance Single submitter
- STK32C p.Pro32Ser Uncertain significance Single submitter
- STK32C p.Pro32Thr Uncertain significance Single submitter
- STK32C p.Pro36Ser Uncertain significance Single submitter
- STK32C p.Pro38Ala Uncertain significance Single submitter
- STK32C p.Pro43Leu Uncertain significance Single submitter
- STK32C p.Pro453His Uncertain significance Single submitter
- STK32C p.Pro455Arg Uncertain significance Single submitter
- STK32C p.Pro463His Uncertain significance Single submitter
- STK32C p.Pro474Leu Uncertain significance Single submitter
- STK32C p.Pro481Ser Uncertain significance Single submitter
- STK32C p.Ser305Phe Uncertain significance Single submitter
- STK32C p.Ser362Thr Uncertain significance Single submitter
- STK32C p.Thr192Ser Uncertain significance Single submitter
- STK32C p.Val138Ile Uncertain significance Single submitter
- STK32C p.Val151Asp Uncertain significance Single submitter
- STK32C p.Val266Ile Uncertain significance Single submitter
- STK32C p.Val307Met Uncertain significance Single submitter
- STK32C p.Val313Met Uncertain significance Single submitter
- STK32C p.Val315Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- STK32C p.Arg246Gln Uncertain significance Single submitter
- STK32C p.Arg246Trp Uncertain significance Single submitter
- STK32C p.Arg365Met Uncertain significance Single submitter
- STK32C p.Arg376Gly Uncertain significance Single submitter
- STK32C p.Glu134Lys Uncertain significance Single submitter
- STK32C p.Ile241Met Uncertain significance Single submitter
- STK32C p.Leu447Phe Uncertain significance Single submitter
- STK32C p.Pro351Leu Uncertain significance Single submitter
- STK32C p.Pro448Leu Likely benign Single submitter
- STK32C p.Val283Ala Uncertain significance Single submitter
- STK32C p.Val283Leu Uncertain significance Single submitter
All STK32C variants
Benign 6
- p.Arg208= Multiple submitters
- p.Asn66Asp Multiple submitters
- p.Glu467Gly Multiple submitters
- p.Leu447= Multiple submitters
- p.Ser485= Multiple submitters
- p.Leu173= Single submitter
Likely benign 4
- p.Arg470His Single submitter
- p.Pro448Leu Single submitter ⚠
- p.Ser471Pro Single submitter
- p.Val151Leu Single submitter
Uncertain significance 58
- p.Ala24Thr Single submitter ⚠
- p.Ala27Gly Single submitter ⚠
- p.Ala468Val Single submitter ⚠
- p.Ala472Thr Single submitter ⚠
- p.Arg113Gln Single submitter ⚠
- p.Arg113Trp Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg246Trp Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg340Gln Single submitter ⚠
- p.Arg365Met Single submitter ⚠
- p.Arg376Gly Single submitter ⚠
- p.Arg449Lys Single submitter ⚠
- p.Arg470Cys Single submitter ⚠
- p.Asn301Lys Single submitter ⚠
- p.Gln60His Single submitter ⚠
- p.Gln94Glu Single submitter ⚠
- p.Glu131Lys Single submitter
- p.Glu134Lys Single submitter ⚠
- p.Glu462Gly Single submitter ⚠
- p.Gly369Ser Single submitter ⚠
- p.Gly477Val Single submitter ⚠
- p.His339Tyr Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Ile213Leu Single submitter ⚠
- p.Ile241Met Single submitter ⚠
- p.Ile261Val Single submitter ⚠
- p.Leu357Pro Single submitter ⚠
- p.Leu447Phe Single submitter ⚠
- p.Lys254Arg Single submitter ⚠
- p.Met118Ile Single submitter ⚠
- p.Met124Val Single submitter ⚠
- p.Met475Thr Single submitter ⚠
- p.Met475Val Single submitter ⚠
- p.Met72Thr Single submitter ⚠
- p.Pro32Ser Single submitter ⚠
- p.Pro32Thr Single submitter ⚠
- p.Pro351Leu Single submitter ⚠
- p.Pro36Ser Single submitter ⚠
- p.Pro38Ala Single submitter ⚠
- p.Pro43Leu Single submitter ⚠
- p.Pro453His Single submitter ⚠
- p.Pro455Arg Single submitter ⚠
- p.Pro463His Single submitter ⚠
- p.Pro474Leu Single submitter ⚠
- p.Pro481Ser Single submitter ⚠
- p.Ser305Phe Single submitter ⚠
- p.Ser362Thr Single submitter ⚠
- p.Thr192Ser Single submitter ⚠
- p.Val138Ile Single submitter ⚠
- p.Val151Asp Single submitter ⚠
- p.Val266Ile Single submitter ⚠
- p.Val283Ala Single submitter ⚠
- p.Val283Leu Single submitter ⚠
- p.Val307Met Single submitter ⚠
- p.Val313Met Single submitter ⚠
- p.Val315Ile Single submitter ⚠