STRADB — 38 ClinVar variants
All ClinVar germline STRADB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Benign · 1 Likely benign · 36 Uncertain significance
Full STRADB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STRADB p.Ala46Val Uncertain significance Single submitter
- STRADB p.Arg100Cys Uncertain significance Single submitter
- STRADB p.Arg100Leu Uncertain significance Single submitter
- STRADB p.Arg329Gln Uncertain significance Single submitter
- STRADB p.Arg41Cys Uncertain significance Single submitter
- STRADB p.Asn163Ser Uncertain significance Single submitter
- STRADB p.Asp250Gly Uncertain significance Single submitter
- STRADB p.Gln214Arg Uncertain significance Single submitter
- STRADB p.Glu158Lys Uncertain significance Single submitter
- STRADB p.Glu411Lys Uncertain significance Single submitter
- STRADB p.Gly83Arg Uncertain significance Single submitter
- STRADB p.His331Tyr Uncertain significance Single submitter
- STRADB p.Ile291Phe Uncertain significance Single submitter
- STRADB p.Ile380Val Uncertain significance Single submitter
- STRADB p.Leu289Phe Uncertain significance Single submitter
- STRADB p.Leu350Phe Uncertain significance Single submitter
- STRADB p.Pro117Ser Uncertain significance Single submitter
- STRADB p.Ser253Ile Uncertain significance Single submitter
- STRADB p.Ser306Ala Uncertain significance Single submitter
- STRADB p.Ser339Phe Uncertain significance Single submitter
- STRADB p.Ser359Ala Uncertain significance Single submitter
- STRADB p.Ser38Pro Uncertain significance Single submitter
- STRADB p.Ser414Leu Uncertain significance Single submitter
- STRADB p.Thr36Ala Uncertain significance Single submitter
- STRADB p.Val32Ile Uncertain significance Single submitter
- STRADB p.Val32Phe Uncertain significance Single submitter
- STRADB p.Val398Glu Uncertain significance Single submitter
- STRADB p.Val55Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- STRADB p.Ala103Pro Uncertain significance Single submitter
- STRADB p.Arg115Trp Uncertain significance Single submitter
- STRADB p.Asp270Val Uncertain significance Single submitter
- STRADB p.Cys6Tyr Uncertain significance Single submitter
- STRADB p.Gly167Glu Uncertain significance Single submitter
- STRADB p.Lys370Thr Uncertain significance Single submitter
- STRADB p.Val210Asp Uncertain significance Single submitter
All STRADB variants
Benign 1
- p.Cys180= Single submitter
Likely benign 1
- p.His331Gln Single submitter
Uncertain significance 36
- p.Ala103Pro Single submitter ⚠
- p.Ala46Val Single submitter ⚠
- p.Arg100Cys Single submitter ⚠
- p.Arg100Leu Single submitter ⚠
- p.Arg115Trp Single submitter ⚠
- p.Arg329Gln Single submitter ⚠
- p.Arg41Cys Single submitter ⚠
- p.Asn163Ser Single submitter ⚠
- p.Asp250Gly Single submitter ⚠
- p.Asp270Val Single submitter ⚠
- p.Cys6Tyr Single submitter ⚠
- p.Gln214Arg Single submitter ⚠
- p.Glu158Lys Single submitter ⚠
- p.Glu411Lys Single submitter ⚠
- p.Gly167Glu Single submitter ⚠
- p.Gly83Arg Single submitter ⚠
- p.His331Tyr Single submitter ⚠
- p.Ile291Phe Single submitter ⚠
- p.Ile380Val Single submitter ⚠
- p.Leu289Phe Single submitter ⚠
- p.Leu350Phe Single submitter ⚠
- p.Lys370Thr Single submitter ⚠
- p.Pro117Ser Single submitter ⚠
- p.Pro231Leu Single submitter
- p.Ser253Ile Single submitter ⚠
- p.Ser306Ala Single submitter ⚠
- p.Ser339Phe Single submitter ⚠
- p.Ser359Ala Single submitter ⚠
- p.Ser38Pro Single submitter ⚠
- p.Ser414Leu Single submitter ⚠
- p.Thr36Ala Single submitter ⚠
- p.Val210Asp Single submitter ⚠
- p.Val32Ile Single submitter ⚠
- p.Val32Phe Single submitter ⚠
- p.Val398Glu Single submitter ⚠
- p.Val55Ile Single submitter ⚠