STRAP — 23 ClinVar variants
All ClinVar germline STRAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
23 Uncertain significance
Full STRAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STRAP p.Ala149Val Uncertain significance Single submitter
- STRAP p.Ala211Val Uncertain significance Single submitter
- STRAP p.Arg125Cys Uncertain significance Single submitter
- STRAP p.Glu331Asp Uncertain significance Single submitter
- STRAP p.Gly24Arg Uncertain significance Single submitter
- STRAP p.Ile126Val Uncertain significance Single submitter
- STRAP p.Ile192Val Uncertain significance Single submitter
- STRAP p.Ile320Thr Uncertain significance Single submitter
- STRAP p.Leu238Val Uncertain significance Single submitter
- STRAP p.Met189Thr Uncertain significance Single submitter
- STRAP p.Met3Val Uncertain significance Single submitter
- STRAP p.Ser153Arg Uncertain significance Single submitter
- STRAP p.Ser23Asn Uncertain significance Single submitter
- STRAP p.Ser23Gly Uncertain significance Single submitter
- STRAP p.Thr173Ala Uncertain significance Single submitter
- STRAP p.Thr173Ser Uncertain significance Single submitter
- STRAP p.Val166Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All STRAP variants
Uncertain significance 23
- p.Ala149Val Single submitter ⚠
- p.Ala211Val Single submitter ⚠
- p.Ala35Gly Single submitter ⚠
- p.Arg125Cys Single submitter ⚠
- p.Asp163Glu Single submitter ⚠
- p.Glu331Asp Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Ile126Val Single submitter ⚠
- p.Ile192Val Single submitter ⚠
- p.Ile320Thr Single submitter ⚠
- p.Leu123Gln Single submitter ⚠
- p.Leu238Val Single submitter ⚠
- p.Met189Thr Single submitter ⚠
- p.Met3Val Single submitter ⚠
- p.Ser11Cys Single submitter ⚠
- p.Ser153Arg Single submitter ⚠
- p.Ser23Asn Single submitter ⚠
- p.Ser23Gly Single submitter ⚠
- p.Thr109Met Single submitter ⚠
- p.Thr173Ala Single submitter ⚠
- p.Thr173Ser Single submitter ⚠
- p.Val166Leu Single submitter ⚠
- p.Val85Met Single submitter