SULT1E1 — 42 ClinVar variants
All ClinVar germline SULT1E1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Benign · 4 Likely benign · 36 Uncertain significance
Full SULT1E1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SULT1E1 p.Arg102Lys Uncertain significance Single submitter
- SULT1E1 p.Arg186His Uncertain significance Single submitter
- SULT1E1 p.Arg256Thr Uncertain significance Single submitter
- SULT1E1 p.Asn150Ser Uncertain significance Single submitter
- SULT1E1 p.Asn76Lys Uncertain significance Single submitter
- SULT1E1 p.Asp194Tyr Uncertain significance Single submitter
- SULT1E1 p.Asp244Asn Uncertain significance Single submitter
- SULT1E1 p.Asp72Asn Uncertain significance Single submitter
- SULT1E1 p.His225Tyr Uncertain significance Single submitter
- SULT1E1 p.Ile207Val Uncertain significance Single submitter
- SULT1E1 p.Leu18Ile Uncertain significance Single submitter
- SULT1E1 p.Met144Thr Uncertain significance Single submitter
- SULT1E1 p.Ser236Pro Uncertain significance Single submitter
- SULT1E1 p.Val136Ala Uncertain significance Single submitter
- SULT1E1 p.Val187Glu Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- SULT1E1 p.Ala35Gly Uncertain significance Single submitter
- SULT1E1 p.Arg36Thr Uncertain significance Single submitter
- SULT1E1 p.Asn130His Uncertain significance Single submitter
- SULT1E1 p.Cys122Gly Uncertain significance Single submitter
- SULT1E1 p.Gln94His Uncertain significance Single submitter
- SULT1E1 p.Glu245Gly Uncertain significance Single submitter
- SULT1E1 p.Glu293Asp Uncertain significance Single submitter
- SULT1E1 p.Glu4Gly Uncertain significance Single submitter
- SULT1E1 p.His225Arg Uncertain significance Single submitter
- SULT1E1 p.Ile60Val Uncertain significance Single submitter
- SULT1E1 p.Leu218Val Uncertain significance Single submitter
- SULT1E1 p.Lys120Met Uncertain significance Single submitter
- SULT1E1 p.Met255Val Uncertain significance Single submitter
- SULT1E1 p.Phe191Ser Uncertain significance Single submitter
- SULT1E1 p.Pro253Ser Uncertain significance Single submitter
- SULT1E1 p.Ser116Leu Uncertain significance Single submitter
- SULT1E1 p.Ser252Leu Uncertain significance Single submitter
- SULT1E1 p.Thr44Ile Uncertain significance Single submitter
- SULT1E1 p.Tyr139His Uncertain significance Single submitter
- SULT1E1 p.Tyr168Cys Uncertain significance Single submitter
- SULT1E1 p.Val136Ile Uncertain significance Single submitter
All SULT1E1 variants
Likely benign 4
- p.Ala32= Single submitter
- p.Asn150Asp Single submitter
- p.Ser252= Single submitter
- p.Val166= Single submitter
Uncertain significance 36
- p.Ala35Gly Single submitter ⚠
- p.Arg102Lys Single submitter ⚠
- p.Arg186His Single submitter ⚠
- p.Arg256Thr Single submitter ⚠
- p.Arg36Thr Single submitter ⚠
- p.Asn130His Single submitter ⚠
- p.Asn150Ser Single submitter ⚠
- p.Asn76Lys Single submitter ⚠
- p.Asp194Tyr Single submitter ⚠
- p.Asp244Asn Single submitter ⚠
- p.Asp72Asn Single submitter ⚠
- p.Cys122Gly Single submitter ⚠
- p.Gln94His Single submitter ⚠
- p.Glu245Gly Single submitter ⚠
- p.Glu293Asp Single submitter ⚠
- p.Glu4Gly Single submitter ⚠
- p.His225Arg Single submitter ⚠
- p.His225Tyr Single submitter ⚠
- p.Ile207Val Single submitter ⚠
- p.Ile60Val Single submitter ⚠
- p.Leu18Ile Single submitter ⚠
- p.Leu218Val Single submitter ⚠
- p.Lys120Met Single submitter ⚠
- p.Met144Thr Single submitter ⚠
- p.Met255Val Single submitter ⚠
- p.Phe191Ser Single submitter ⚠
- p.Pro253Ser Single submitter ⚠
- p.Ser116Leu Single submitter ⚠
- p.Ser236Pro Single submitter ⚠
- p.Ser252Leu Single submitter ⚠
- p.Thr44Ile Single submitter ⚠
- p.Tyr139His Single submitter ⚠
- p.Tyr168Cys Single submitter ⚠
- p.Val136Ala Single submitter ⚠
- p.Val136Ile Single submitter ⚠
- p.Val187Glu Single submitter ⚠