SULT2A1 — 30 ClinVar variants
All ClinVar germline SULT2A1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Benign · 4 Likely benign · 24 Uncertain significance
Full SULT2A1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SULT2A1 p.Arg19Ser Uncertain significance Single submitter
- SULT2A1 p.Glu209Lys Uncertain significance Single submitter
- SULT2A1 p.Gly130Ser Uncertain significance Single submitter
- SULT2A1 p.Gly17Asp Uncertain significance Single submitter
- SULT2A1 p.Leu50Val Uncertain significance Single submitter
- SULT2A1 p.Lys227Arg Uncertain significance Single submitter
- SULT2A1 p.Lys64Asn Uncertain significance Single submitter
- SULT2A1 p.Met120Thr Uncertain significance Single submitter
- SULT2A1 p.Pro208Ser Uncertain significance Single submitter
- SULT2A1 p.Ser222Asn Uncertain significance Single submitter
- SULT2A1 p.Thr90Met Uncertain significance Single submitter
- SULT2A1 p.Trp152Gly Uncertain significance Single submitter
- SULT2A1 p.Val31Ala Uncertain significance Single submitter
- SULT2A1 p.Val31Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SULT2A1 p.Arg27Cys Uncertain significance Single submitter
- SULT2A1 p.Arg94His Uncertain significance Single submitter
- SULT2A1 p.Gln262Lys Uncertain significance Single submitter
- SULT2A1 p.Phe266Leu Uncertain significance Single submitter
- SULT2A1 p.Pro101Ser Uncertain significance Single submitter
- SULT2A1 p.Pro106Arg Uncertain significance Single submitter
- SULT2A1 p.Ser111Ile Uncertain significance Single submitter
- SULT2A1 p.Tyr184His Uncertain significance Single submitter
All SULT2A1 variants
Benign 2
- p.Ala63Pro Multiple submitters
- p.Ala86= Multiple submitters
Likely benign 4
- p.His168Arg Single submitter
- p.Lys177Glu Single submitter
- p.Lys227Glu Single submitter
- p.Met120Ile Single submitter
Uncertain significance 24
- p.Arg19Ser Single submitter ⚠
- p.Arg27Cys Single submitter ⚠
- p.Arg74Gln Single submitter
- p.Arg94His Single submitter ⚠
- p.Gln262Lys Single submitter ⚠
- p.Glu209Lys Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly17Asp Single submitter ⚠
- p.Leu50Val Single submitter ⚠
- p.Lys227Arg Single submitter ⚠
- p.Lys64Asn Single submitter ⚠
- p.Met120Thr Single submitter ⚠
- p.Phe266Leu Single submitter ⚠
- p.Pro101Ser Single submitter ⚠
- p.Pro106Arg Single submitter ⚠
- p.Pro208Ser Single submitter ⚠
- p.Ser111Ile Single submitter ⚠
- p.Ser183Asn Single submitter
- p.Ser222Asn Single submitter ⚠
- p.Thr90Met Single submitter ⚠
- p.Trp152Gly Single submitter ⚠
- p.Tyr184His Single submitter ⚠
- p.Val31Ala Single submitter ⚠
- p.Val31Met Single submitter ⚠