SUMO3 — 8 ClinVar variants
All ClinVar germline SUMO3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
2 Benign · 1 Likely benign · 5 Uncertain significance
Full SUMO3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 3
The independent predictors disagree with each other — read with care.
All SUMO3 variants
Benign 2
- c.150+39C>T Multiple submitters
- p.Pro94Leu Multiple submitters
Likely benign 1
- p.Ser102Gly Single submitter
Uncertain significance 5
- p.Asp81Gly Single submitter ⚠
- p.Ile66Val Single submitter ⚠
- p.Lys5Thr Single submitter ⚠
- p.Met54Val Single submitter ⚠
- p.Ser40Asn Single submitter ⚠