SURF4 — 21 ClinVar variants
All ClinVar germline SURF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
21 Uncertain significance
Full SURF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SURF4 p.Ala177Thr Uncertain significance Single submitter
- SURF4 p.Ala214Thr Uncertain significance Single submitter
- SURF4 p.Arg135His Uncertain significance Single submitter
- SURF4 p.Arg19Cys Uncertain significance Single submitter
- SURF4 p.Arg19Leu Uncertain significance Single submitter
- SURF4 p.Asn220Ser Uncertain significance Single submitter
- SURF4 p.Asp113Asn Uncertain significance Single submitter
- SURF4 p.Gly96Trp Uncertain significance Single submitter
- SURF4 p.Ile225Val Uncertain significance Single submitter
- SURF4 p.Leu103Val Uncertain significance Single submitter
- SURF4 p.Met148Thr Uncertain significance Single submitter
- SURF4 p.Met262Val Uncertain significance Single submitter
- SURF4 p.Thr171Ile Uncertain significance Single submitter
- SURF4 p.Tyr92His Uncertain significance Single submitter
- SURF4 p.Tyr92Phe Uncertain significance Single submitter
- SURF4 p.Val145Ile Uncertain significance Single submitter
- SURF4 p.Val217Ile Uncertain significance Single submitter
- SURF4 p.Val217Leu Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All SURF4 variants
Uncertain significance 21
- p.Ala177Thr Single submitter ⚠
- p.Ala214Thr Single submitter ⚠
- p.Arg135His Single submitter ⚠
- p.Arg19Cys Single submitter ⚠
- p.Arg19Leu Single submitter ⚠
- p.Asn220Ser Single submitter ⚠
- p.Asp113Asn Single submitter ⚠
- p.Gly62Ser Single submitter ⚠
- p.Gly96Trp Single submitter ⚠
- p.Ile225Val Single submitter ⚠
- p.Leu103Val Single submitter ⚠
- p.Met148Thr Single submitter ⚠
- p.Met262Val Single submitter ⚠
- p.Phe179Cys Single submitter ⚠
- p.Ser49Ile Single submitter ⚠
- p.Thr171Ile Single submitter ⚠
- p.Tyr92His Single submitter ⚠
- p.Tyr92Phe Single submitter ⚠
- p.Val145Ile Single submitter ⚠
- p.Val217Ile Single submitter ⚠
- p.Val217Leu Single submitter ⚠