Sugi Variant

Sugi Variant/SYK

SYK — 98 ClinVar variants

All ClinVar germline SYK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →

1 Pathogenic · 2 Likely pathogenic · 2 Conflicting · 26 Benign · 3 Benign/Likely benign · 16 Likely benign · 48 Uncertain significance

Full SYK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 48

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 31

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 14

The independent predictors disagree with each other — read with care.

All SYK variants

Pathogenic 1

Likely pathogenic 2

Conflicting classifications of pathogenicity 2

Benign 26

Benign/Likely benign 3

Likely benign 16

Uncertain significance 48