SYNGR2 — 25 ClinVar variants
All ClinVar germline SYNGR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
2 Likely benign · 23 Uncertain significance
Full SYNGR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SYNGR2 p.Ala193Asp Uncertain significance Single submitter
- SYNGR2 p.Ala90Thr Uncertain significance Single submitter
- SYNGR2 p.Ala98Thr Uncertain significance Single submitter
- SYNGR2 p.Arg101Pro Uncertain significance Single submitter
- SYNGR2 p.Asp176Asn Uncertain significance Single submitter
- SYNGR2 p.Asp176Gly Uncertain significance Single submitter
- SYNGR2 p.Asp89Asn Uncertain significance Single submitter
- SYNGR2 p.Glu65Asp Uncertain significance Single submitter
- SYNGR2 p.Gly141Glu Uncertain significance Single submitter
- SYNGR2 p.Ile74Thr Uncertain significance Single submitter
- SYNGR2 p.Phe111Leu Uncertain significance Single submitter
- SYNGR2 p.Pro135Leu Uncertain significance Single submitter
- SYNGR2 p.Ser96Arg Uncertain significance Single submitter
- SYNGR2 p.Tyr44Cys Uncertain significance Single submitter
- SYNGR2 p.Val138Met Uncertain significance Single submitter
- SYNGR2 p.Val182Ile Uncertain significance Single submitter
- SYNGR2 p.Val60Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- SYNGR2 p.Ala36Thr Uncertain significance Single submitter
- SYNGR2 p.Asn64Ser Uncertain significance Single submitter
- SYNGR2 p.Asp137Asn Uncertain significance Single submitter
- SYNGR2 p.Leu165Gln Uncertain significance Single submitter
- SYNGR2 p.Phe92Leu Uncertain significance Single submitter
- SYNGR2 p.Val39Met Uncertain significance Single submitter
All SYNGR2 variants
Likely benign 2
- p.Ala90Val Single submitter
- p.Glu53Lys Single submitter
Uncertain significance 23
- p.Ala193Asp Single submitter ⚠
- p.Ala36Thr Single submitter ⚠
- p.Ala90Thr Single submitter ⚠
- p.Ala98Thr Single submitter ⚠
- p.Arg101Pro Single submitter ⚠
- p.Asn64Ser Single submitter ⚠
- p.Asp137Asn Single submitter ⚠
- p.Asp176Asn Single submitter ⚠
- p.Asp176Gly Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Glu65Asp Single submitter ⚠
- p.Gly141Glu Single submitter ⚠
- p.Ile74Thr Single submitter ⚠
- p.Leu165Gln Single submitter ⚠
- p.Phe111Leu Single submitter ⚠
- p.Phe92Leu Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Ser96Arg Single submitter ⚠
- p.Tyr44Cys Single submitter ⚠
- p.Val138Met Single submitter ⚠
- p.Val182Ile Single submitter ⚠
- p.Val39Met Single submitter ⚠
- p.Val60Met Single submitter ⚠