SYPL1 — 38 ClinVar variants
All ClinVar germline SYPL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
38 Uncertain significance
Full SYPL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SYPL1 p.Ser13Gly Uncertain significance Multiple submitters
- SYPL1 p.Arg9His Uncertain significance Single submitter
- SYPL1 p.Asn225Ser Uncertain significance Single submitter
- SYPL1 p.Asp86Glu Uncertain significance Single submitter
-
SYPL1 p.Cys33Tyr
Uncertain significance
Single submitter
intellectual disability
- SYPL1 p.Cys80Gly Uncertain significance Single submitter
- SYPL1 p.Gln232Glu Uncertain significance Single submitter
- SYPL1 p.Glu68Lys Uncertain significance Single submitter
- SYPL1 p.Gly165Ser Uncertain significance Single submitter
- SYPL1 p.Gly16Arg Uncertain significance Single submitter
- SYPL1 p.Gly200Ser Uncertain significance Single submitter
- SYPL1 p.Ile169Thr Uncertain significance Single submitter
- SYPL1 p.Ile42Phe Uncertain significance Single submitter
- SYPL1 p.Ile42Val Uncertain significance Single submitter
- SYPL1 p.Ile5Phe Uncertain significance Single submitter
- SYPL1 p.Ile5Ser Uncertain significance Single submitter
- SYPL1 p.Ile6Met Uncertain significance Single submitter
- SYPL1 p.Leu109Pro Uncertain significance Single submitter
- SYPL1 p.Leu181Val Uncertain significance Single submitter
- SYPL1 p.Leu7Val Uncertain significance Single submitter
- SYPL1 p.Lys54Glu Uncertain significance Single submitter
- SYPL1 p.Met133Thr Uncertain significance Single submitter
- SYPL1 p.Phe30Val Uncertain significance Single submitter
- SYPL1 p.Pro173Leu Uncertain significance Single submitter
- SYPL1 p.Pro73Leu Uncertain significance Single submitter
- SYPL1 p.Thr102Asn Uncertain significance Single submitter
- SYPL1 p.Thr122Lys Uncertain significance Single submitter
- SYPL1 p.Thr59Ser Uncertain significance Single submitter
- SYPL1 p.Tyr215Cys Uncertain significance Single submitter
- SYPL1 p.Tyr6Cys Uncertain significance Single submitter
- SYPL1 p.Val107Met Uncertain significance Single submitter
- SYPL1 p.Val82Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- SYPL1 p.Arg129Cys Uncertain significance Single submitter
- SYPL1 p.Glu13Lys Uncertain significance Single submitter
- SYPL1 p.Leu220Pro Uncertain significance Single submitter
- SYPL1 p.Pro48Ser Uncertain significance Single submitter
- SYPL1 p.Thr40Ile Uncertain significance Single submitter
- SYPL1 p.Val119Phe Uncertain significance Single submitter
All SYPL1 variants
Uncertain significance 38
- p.Ser13Gly Multiple submitters ⚠
- p.Arg129Cys Single submitter ⚠
- p.Arg9His Single submitter ⚠
- p.Asn225Ser Single submitter ⚠
- p.Asp86Glu Single submitter ⚠
- p.Cys33Tyr Single submitter intellectual disability ⚠
- p.Cys80Gly Single submitter ⚠
- p.Gln232Glu Single submitter ⚠
- p.Glu13Lys Single submitter ⚠
- p.Glu68Lys Single submitter ⚠
- p.Gly165Ser Single submitter ⚠
- p.Gly16Arg Single submitter ⚠
- p.Gly200Ser Single submitter ⚠
- p.Ile169Thr Single submitter ⚠
- p.Ile42Phe Single submitter ⚠
- p.Ile42Val Single submitter ⚠
- p.Ile5Phe Single submitter ⚠
- p.Ile5Ser Single submitter ⚠
- p.Ile6Met Single submitter ⚠
- p.Leu109Pro Single submitter ⚠
- p.Leu181Val Single submitter ⚠
- p.Leu220Pro Single submitter ⚠
- p.Leu7Val Single submitter ⚠
- p.Lys54Glu Single submitter ⚠
- p.Met133Thr Single submitter ⚠
- p.Phe30Val Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro48Ser Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Thr102Asn Single submitter ⚠
- p.Thr122Lys Single submitter ⚠
- p.Thr40Ile Single submitter ⚠
- p.Thr59Ser Single submitter ⚠
- p.Tyr215Cys Single submitter ⚠
- p.Tyr6Cys Single submitter ⚠
- p.Val107Met Single submitter ⚠
- p.Val119Phe Single submitter ⚠
- p.Val82Ile Single submitter ⚠