TAS2R10 — 47 ClinVar variants
All ClinVar germline TAS2R10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
5 Likely benign · 42 Uncertain significance
Full TAS2R10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R10 p.Ala221Thr Uncertain significance Single submitter
- TAS2R10 p.Arg3Cys Uncertain significance Single submitter
- TAS2R10 p.Asn204Lys Uncertain significance Single submitter
- TAS2R10 p.Asn204Tyr Uncertain significance Single submitter
- TAS2R10 p.Asn218Lys Uncertain significance Single submitter
- TAS2R10 p.Asn24Thr Uncertain significance Single submitter
- TAS2R10 p.Cys249Arg Uncertain significance Single submitter
- TAS2R10 p.Cys249Ser Uncertain significance Single submitter
- TAS2R10 p.Gly181Ala Uncertain significance Single submitter
- TAS2R10 p.Gly49Ser Uncertain significance Single submitter
- TAS2R10 p.Gly78Ser Uncertain significance Single submitter
- TAS2R10 p.Ile198Thr Uncertain significance Single submitter
- TAS2R10 p.Ile61Val Uncertain significance Single submitter
- TAS2R10 p.Leu29Val Uncertain significance Single submitter
- TAS2R10 p.Lys168Thr Uncertain significance Single submitter
- TAS2R10 p.Lys283Asn Uncertain significance Single submitter
- TAS2R10 p.Lys39Gln Uncertain significance Single submitter
- TAS2R10 p.Met207Val Uncertain significance Single submitter
- TAS2R10 p.Phe135Tyr Uncertain significance Single submitter
- TAS2R10 p.Phe186Leu Uncertain significance Single submitter
- TAS2R10 p.Phe56Tyr Uncertain significance Single submitter
- TAS2R10 p.Ser189Tyr Uncertain significance Single submitter
- TAS2R10 p.Ser231Tyr Uncertain significance Single submitter
- TAS2R10 p.Ser282Arg Uncertain significance Single submitter
- TAS2R10 p.Ser282Cys Uncertain significance Single submitter
- TAS2R10 p.Ser71Phe Uncertain significance Single submitter
- TAS2R10 p.Thr264Ala Uncertain significance Single submitter
- TAS2R10 p.Tyr106Cys Uncertain significance Single submitter
- TAS2R10 p.Tyr269Cys Uncertain significance Single submitter
- TAS2R10 p.Val13Leu Uncertain significance Single submitter
- TAS2R10 p.Val5Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TAS2R10 p.Asn112Thr Uncertain significance Single submitter
- TAS2R10 p.Asn31Lys Uncertain significance Single submitter
- TAS2R10 p.Gly242Cys Uncertain significance Single submitter
- TAS2R10 p.His203Arg Uncertain significance Single submitter
- TAS2R10 p.Ile52Asn Uncertain significance Single submitter
- TAS2R10 p.Leu190Arg Uncertain significance Single submitter
- TAS2R10 p.Lys227Glu Uncertain significance Single submitter
- TAS2R10 p.Phe70Ser Uncertain significance Single submitter
- TAS2R10 p.Phe70Val Uncertain significance Single submitter
- TAS2R10 p.Phe98Ser Uncertain significance Single submitter
All TAS2R10 variants
Likely benign 5
- p.Ala145Pro Single submitter
- p.Gln68Lys Single submitter
- p.Ile176Val Single submitter
- p.Phe131Leu Single submitter
- p.Ser209Leu Single submitter
Uncertain significance 42
- p.Ala221Thr Single submitter ⚠
- p.Arg3Cys Single submitter ⚠
- p.Asn112Thr Single submitter ⚠
- p.Asn204Lys Single submitter ⚠
- p.Asn204Tyr Single submitter ⚠
- p.Asn218Lys Single submitter ⚠
- p.Asn24Thr Single submitter ⚠
- p.Asn31Lys Single submitter ⚠
- p.Cys249Arg Single submitter ⚠
- p.Cys249Ser Single submitter ⚠
- p.Gly181Ala Single submitter ⚠
- p.Gly242Cys Single submitter ⚠
- p.Gly49Ser Single submitter ⚠
- p.Gly78Ser Single submitter ⚠
- p.His203Arg Single submitter ⚠
- p.Ile198Thr Single submitter ⚠
- p.Ile52Asn Single submitter ⚠
- p.Ile61Val Single submitter ⚠
- p.Leu190Arg Single submitter ⚠
- p.Leu29Val Single submitter ⚠
- p.Lys168Thr Single submitter ⚠
- p.Lys227Glu Single submitter ⚠
- p.Lys283Asn Single submitter ⚠
- p.Lys39Gln Single submitter ⚠
- p.Met207Val Single submitter ⚠
- p.Phe135Tyr Single submitter ⚠
- p.Phe186Leu Single submitter ⚠
- p.Phe56Tyr Single submitter ⚠
- p.Phe70Ser Single submitter ⚠
- p.Phe70Val Single submitter ⚠
- p.Phe98Ser Single submitter ⚠
- p.Pro270Ser Single submitter
- p.Ser189Tyr Single submitter ⚠
- p.Ser231Tyr Single submitter ⚠
- p.Ser282Arg Single submitter ⚠
- p.Ser282Cys Single submitter ⚠
- p.Ser71Phe Single submitter ⚠
- p.Thr264Ala Single submitter ⚠
- p.Tyr106Cys Single submitter ⚠
- p.Tyr269Cys Single submitter ⚠
- p.Val13Leu Single submitter ⚠
- p.Val5Met Single submitter ⚠