TAS2R13 — 50 ClinVar variants
All ClinVar germline TAS2R13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Benign · 3 Likely benign · 46 Uncertain significance
Full TAS2R13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R13 p.Ala112Val Uncertain significance Single submitter
- TAS2R13 p.Ala286Thr Uncertain significance Single submitter
- TAS2R13 p.Ala4Ser Uncertain significance Single submitter
- TAS2R13 p.Arg223Thr Uncertain significance Single submitter
- TAS2R13 p.Asn144His Uncertain significance Single submitter
- TAS2R13 p.Asn21Ser Uncertain significance Single submitter
- TAS2R13 p.Asp45Asn Uncertain significance Single submitter
- TAS2R13 p.Gly270Arg Uncertain significance Single submitter
- TAS2R13 p.Gly270Glu Uncertain significance Single submitter
- TAS2R13 p.His151Arg Uncertain significance Single submitter
- TAS2R13 p.His277Leu Uncertain significance Single submitter
- TAS2R13 p.Ile196Val Uncertain significance Single submitter
- TAS2R13 p.Ile262Val Uncertain significance Single submitter
- TAS2R13 p.Ile59Thr Uncertain significance Single submitter
- TAS2R13 p.Ile62Met Uncertain significance Single submitter
- TAS2R13 p.Ile75Met Uncertain significance Single submitter
- TAS2R13 p.Ile84Val Uncertain significance Single submitter
- TAS2R13 p.Leu22Met Uncertain significance Single submitter
- TAS2R13 p.Leu41Val Uncertain significance Single submitter
- TAS2R13 p.Leu47Phe Uncertain significance Single submitter
- TAS2R13 p.Leu99Phe Uncertain significance Single submitter
- TAS2R13 p.Lys232Arg Uncertain significance Single submitter
- TAS2R13 p.Met185Val Uncertain significance Single submitter
- TAS2R13 p.Met264Val Uncertain significance Single submitter
- TAS2R13 p.Phe244Val Uncertain significance Single submitter
- TAS2R13 p.Phe245Leu Uncertain significance Single submitter
- TAS2R13 p.Phe9Ser Uncertain significance Single submitter
- TAS2R13 p.Pro190Ala Uncertain significance Single submitter
- TAS2R13 p.Pro222Leu Uncertain significance Single submitter
- TAS2R13 p.Ser88Gly Uncertain significance Single submitter
- TAS2R13 p.Thr10Ile Uncertain significance Single submitter
- TAS2R13 p.Thr10Ser Uncertain significance Single submitter
- TAS2R13 p.Thr137Asn Uncertain significance Single submitter
- TAS2R13 p.Thr163Ser Uncertain significance Single submitter
- TAS2R13 p.Thr182Ala Uncertain significance Single submitter
- TAS2R13 p.Thr182Ile Uncertain significance Single submitter
- TAS2R13 p.Thr268Met Uncertain significance Single submitter
- TAS2R13 p.Thr80Ile Uncertain significance Single submitter
- TAS2R13 p.Trp155Cys Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TAS2R13 variants
Benign 1
- p.Leu131= Multiple submitters
Likely benign 3
- p.Phe172Leu Single submitter
- p.Ser65Asn Single submitter
- p.Tyr159Cys Single submitter
Uncertain significance 46
- p.Ser23Arg Multiple submitters ⚠
- p.Ala112Val Single submitter ⚠
- p.Ala286Thr Single submitter ⚠
- p.Ala4Ser Single submitter ⚠
- p.Arg223Thr Single submitter ⚠
- p.Asn144His Single submitter ⚠
- p.Asn21Ser Single submitter ⚠
- p.Asn24His Single submitter ⚠
- p.Asn24Ile Single submitter
- p.Asp45Asn Single submitter ⚠
- p.Gly270Arg Single submitter ⚠
- p.Gly270Glu Single submitter ⚠
- p.His151Arg Single submitter ⚠
- p.His277Leu Single submitter ⚠
- p.Ile196Val Single submitter ⚠
- p.Ile262Val Single submitter ⚠
- p.Ile59Thr Single submitter ⚠
- p.Ile62Met Single submitter ⚠
- p.Ile75Met Single submitter ⚠
- p.Ile84Val Single submitter ⚠
- p.Leu109His Single submitter
- p.Leu22Met Single submitter ⚠
- p.Leu280Pro Single submitter ⚠
- p.Leu41Val Single submitter ⚠
- p.Leu47Phe Single submitter ⚠
- p.Leu58Arg Single submitter ⚠
- p.Leu99Phe Single submitter ⚠
- p.Lys232Arg Single submitter ⚠
- p.Met185Val Single submitter ⚠
- p.Met264Val Single submitter ⚠
- p.Phe244Val Single submitter ⚠
- p.Phe245Leu Single submitter ⚠
- p.Phe9Ser Single submitter ⚠
- p.Pro190Ala Single submitter ⚠
- p.Pro222Leu Single submitter ⚠
- p.Ser88Gly Single submitter ⚠
- p.Thr10Ile Single submitter ⚠
- p.Thr10Ser Single submitter ⚠
- p.Thr137Asn Single submitter ⚠
- p.Thr163Ser Single submitter ⚠
- p.Thr182Ala Single submitter ⚠
- p.Thr182Ile Single submitter ⚠
- p.Thr268Met Single submitter ⚠
- p.Thr80Ile Single submitter ⚠
- p.Trp155Cys Single submitter ⚠
- p.Val193Gly Single submitter ⚠