TAS2R16 — 41 ClinVar variants
All ClinVar germline TAS2R16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Benign · 2 Likely benign · 37 Uncertain significance
Full TAS2R16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R16 p.Arg56Cys Uncertain significance Single submitter
-
TAS2R16 p.Asn172Lys
Uncertain significance
Single submitter
alcohol dependence
- TAS2R16 p.Cys256Tyr Uncertain significance Single submitter
- TAS2R16 p.Cys79Phe Uncertain significance Single submitter
- TAS2R16 p.Gly249Asp Uncertain significance Single submitter
- TAS2R16 p.His174Arg Uncertain significance Single submitter
- TAS2R16 p.Ile114Thr Uncertain significance Single submitter
- TAS2R16 p.Ile141Val Uncertain significance Single submitter
- TAS2R16 p.Ile150Thr Uncertain significance Single submitter
- TAS2R16 p.Ile197Val Uncertain significance Single submitter
- TAS2R16 p.Ile243Met Uncertain significance Single submitter
- TAS2R16 p.Ile245Phe Uncertain significance Single submitter
- TAS2R16 p.Ile54Phe Uncertain significance Single submitter
- TAS2R16 p.Ile83Val Uncertain significance Single submitter
- TAS2R16 p.Leu232Ile Uncertain significance Single submitter
- TAS2R16 p.Leu244Phe Uncertain significance Single submitter
- TAS2R16 p.Leu65Pro Uncertain significance Single submitter
- TAS2R16 p.Leu74Trp Uncertain significance Single submitter
- TAS2R16 p.Met277Thr Uncertain significance Single submitter
- TAS2R16 p.Phe72Ser Uncertain significance Single submitter
- TAS2R16 p.Pro3Leu Uncertain significance Single submitter
- TAS2R16 p.Ser211Arg Uncertain significance Single submitter
- TAS2R16 p.Ser279Asn Uncertain significance Single submitter
- TAS2R16 p.Thr156Ile Uncertain significance Single submitter
- TAS2R16 p.Thr224Ala Uncertain significance Single submitter
- TAS2R16 p.Thr237Ile Uncertain significance Single submitter
- TAS2R16 p.Thr282Met Uncertain significance Single submitter
- TAS2R16 p.Thr7Ile Uncertain significance Single submitter
- TAS2R16 p.Trp261Cys Uncertain significance Single submitter
- TAS2R16 p.Tyr76Cys Uncertain significance Single submitter
- TAS2R16 p.Val107Phe Uncertain significance Single submitter
- TAS2R16 p.Val15Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TAS2R16 variants
Benign 2
- p.Arg222His No assertion criteria TAS2R16-related disorder
- p.Thr282= No assertion criteria TAS2R16-related disorder
Uncertain significance 37
- p.Arg40Ile Single submitter ⚠
- p.Arg56Cys Single submitter ⚠
- p.Asn172Lys Single submitter alcohol dependence ⚠
- p.Cys256Tyr Single submitter ⚠
- p.Cys79Phe Single submitter ⚠
- p.Glu17Lys Single submitter ⚠
- p.Gly249Asp Single submitter ⚠
- p.His174Arg Single submitter ⚠
- p.Ile114Thr Single submitter ⚠
- p.Ile141Val Single submitter ⚠
- p.Ile150Thr Single submitter ⚠
- p.Ile197Val Single submitter ⚠
- p.Ile207Arg Single submitter ⚠
- p.Ile243Met Single submitter ⚠
- p.Ile245Phe Single submitter ⚠
- p.Ile54Phe Single submitter ⚠
- p.Ile83Val Single submitter ⚠
- p.Leu232Ile Single submitter ⚠
- p.Leu244Phe Single submitter ⚠
- p.Leu65Pro Single submitter ⚠
- p.Leu74Trp Single submitter ⚠
- p.Met277Thr Single submitter ⚠
- p.Phe192Leu Single submitter ⚠
- p.Phe72Ser Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Ser211Arg Single submitter ⚠
- p.Ser279Asn Single submitter ⚠
- p.Thr156Ile Single submitter ⚠
- p.Thr224Ala Single submitter ⚠
- p.Thr237Ile Single submitter ⚠
- p.Thr282Met Single submitter ⚠
- p.Thr7Ile Single submitter ⚠
- p.Trp261Cys Single submitter ⚠
- p.Tyr76Cys Single submitter ⚠
- p.Val107Phe Single submitter ⚠
- p.Val15Ala Single submitter ⚠
- p.Val183Asp Single submitter ⚠