TAS2R20 — 48 ClinVar variants
All ClinVar germline TAS2R20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Benign · 5 Likely benign · 42 Uncertain significance
Full TAS2R20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R20 p.Ala44Val Uncertain significance Single submitter
- TAS2R20 p.Arg38Lys Uncertain significance Single submitter
- TAS2R20 p.Asn170Lys Uncertain significance Single submitter
- TAS2R20 p.Cys299Phe Uncertain significance Single submitter
- TAS2R20 p.Gly160Glu Uncertain significance Single submitter
- TAS2R20 p.Ile193Met Uncertain significance Single submitter
- TAS2R20 p.Ile223Phe Uncertain significance Single submitter
- TAS2R20 p.Ile223Thr Uncertain significance Single submitter
- TAS2R20 p.Ile269Leu Uncertain significance Single submitter
- TAS2R20 p.Ile30Thr Uncertain significance Single submitter
- TAS2R20 p.Ile7Thr Uncertain significance Single submitter
- TAS2R20 p.Leu116Arg Uncertain significance Single submitter
- TAS2R20 p.Leu177Phe Uncertain significance Single submitter
- TAS2R20 p.Met262Lys Uncertain significance Single submitter
- TAS2R20 p.Thr149Ser Uncertain significance Single submitter
- TAS2R20 p.Thr285Met Uncertain significance Single submitter
- TAS2R20 p.Thr289Ile Uncertain significance Single submitter
- TAS2R20 p.Trp295Cys Uncertain significance Single submitter
- TAS2R20 p.Trp35Cys Uncertain significance Single submitter
- TAS2R20 p.Trp60Cys Uncertain significance Single submitter
- TAS2R20 p.Tyr150Cys Uncertain significance Single submitter
- TAS2R20 p.Tyr241Cys Uncertain significance Single submitter
- TAS2R20 p.Val111Ile Uncertain significance Single submitter
- TAS2R20 p.Val131Leu Uncertain significance Single submitter
- TAS2R20 p.Val13Ala Uncertain significance Single submitter
- TAS2R20 p.Val153Glu Uncertain significance Single submitter
- TAS2R20 p.Val61Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- TAS2R20 p.Val70Gly Benign Multiple submitters
- TAS2R20 p.Gly135Glu Uncertain significance Single submitter
- TAS2R20 p.His143Pro Uncertain significance Single submitter
- TAS2R20 p.His148Pro Uncertain significance Single submitter
- TAS2R20 p.His205Arg Uncertain significance Single submitter
- TAS2R20 p.His93Gln Uncertain significance Single submitter
- TAS2R20 p.Ile47Ser Uncertain significance Single submitter
- TAS2R20 p.Leu102Phe Uncertain significance Single submitter
- TAS2R20 p.Leu238Pro Uncertain significance Single submitter
- TAS2R20 p.Lys122Glu Uncertain significance Single submitter
- TAS2R20 p.Pro219Arg Uncertain significance Single submitter
- TAS2R20 p.Pro73Ala Uncertain significance Single submitter
- TAS2R20 p.Ser103Arg Uncertain significance Single submitter
- TAS2R20 p.Val129Gly Uncertain significance Single submitter
-
TAS2R20 p.Ser85Cys
Uncertain significance
No assertion criteria
prostate cancer
All TAS2R20 variants
Benign 1
- p.Val70Gly Multiple submitters ⚠
Likely benign 5
- p.Lys226Arg Single submitter
- p.Met262Ile Single submitter
- p.Thr149Met Single submitter
- p.Val133Leu Single submitter
- p.Val162Ile Single submitter
Uncertain significance 42
- p.Ala44Val Single submitter ⚠
- p.Arg38Lys Single submitter ⚠
- p.Asn170Lys Single submitter ⚠
- p.Asn24Thr Single submitter
- p.Cys299Phe Single submitter ⚠
- p.Gly135Glu Single submitter ⚠
- p.Gly160Glu Single submitter ⚠
- p.His143Pro Single submitter ⚠
- p.His148Pro Single submitter ⚠
- p.His205Arg Single submitter ⚠
- p.His93Gln Single submitter ⚠
- p.Ile193Met Single submitter ⚠
- p.Ile223Phe Single submitter ⚠
- p.Ile223Thr Single submitter ⚠
- p.Ile269Leu Single submitter ⚠
- p.Ile30Thr Single submitter ⚠
- p.Ile47Ser Single submitter ⚠
- p.Ile7Thr Single submitter ⚠
- p.Leu102Phe Single submitter ⚠
- p.Leu116Arg Single submitter ⚠
- p.Leu177Phe Single submitter ⚠
- p.Leu238Pro Single submitter ⚠
- p.Lys122Glu Single submitter ⚠
- p.Met262Lys Single submitter ⚠
- p.Pro219Arg Single submitter ⚠
- p.Pro73Ala Single submitter ⚠
- p.Ser103Arg Single submitter ⚠
- p.Thr149Ser Single submitter ⚠
- p.Thr285Met Single submitter ⚠
- p.Thr289Ile Single submitter ⚠
- p.Trp295Cys Single submitter ⚠
- p.Trp35Cys Single submitter ⚠
- p.Trp60Cys Single submitter ⚠
- p.Tyr150Cys Single submitter ⚠
- p.Tyr241Cys Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val129Gly Single submitter ⚠
- p.Val131Leu Single submitter ⚠
- p.Val13Ala Single submitter ⚠
- p.Val153Glu Single submitter ⚠
- p.Val61Ala Single submitter ⚠
- p.Ser85Cys No assertion criteria prostate cancer ⚠