TAS2R30 — 48 ClinVar variants
All ClinVar germline TAS2R30 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
8 Likely benign · 40 Uncertain significance
Full TAS2R30 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R30 p.Ala227Thr Uncertain significance Single submitter
- TAS2R30 p.Ala315Thr Uncertain significance Single submitter
- TAS2R30 p.Ala52Ser Uncertain significance Single submitter
- TAS2R30 p.Arg295Gln Uncertain significance Single submitter
- TAS2R30 p.Arg304Lys Uncertain significance Single submitter
- TAS2R30 p.Asn112Ser Uncertain significance Single submitter
- TAS2R30 p.Gly215Arg Uncertain significance Single submitter
- TAS2R30 p.His296Tyr Uncertain significance Single submitter
- TAS2R30 p.His309Arg Uncertain significance Single submitter
- TAS2R30 p.His65Gln Uncertain significance Single submitter
- TAS2R30 p.Ile117Val Uncertain significance Single submitter
- TAS2R30 p.Ile121Met Uncertain significance Single submitter
- TAS2R30 p.Ile16Leu Uncertain significance Single submitter
- TAS2R30 p.Ile19Met Uncertain significance Single submitter
- TAS2R30 p.Ile225Val Uncertain significance Single submitter
- TAS2R30 p.Ile27Met Uncertain significance Single submitter
- TAS2R30 p.Leu130Met Uncertain significance Single submitter
- TAS2R30 p.Leu182Val Uncertain significance Single submitter
- TAS2R30 p.Lys122Arg Uncertain significance Single submitter
- TAS2R30 p.Lys302Thr Uncertain significance Single submitter
- TAS2R30 p.Met262Ile Uncertain significance Single submitter
- TAS2R30 p.Met262Leu Uncertain significance Single submitter
- TAS2R30 p.Phe9Leu Uncertain significance Single submitter
- TAS2R30 p.Ser10Phe Uncertain significance Single submitter
- TAS2R30 p.Ser77Asn Uncertain significance Single submitter
- TAS2R30 p.Thr69Ala Uncertain significance Single submitter
- TAS2R30 p.Thr83Ser Uncertain significance Single submitter
- TAS2R30 p.Trp164Cys Uncertain significance Single submitter
- TAS2R30 p.Trp60Leu Uncertain significance Single submitter
- TAS2R30 p.Tyr158Cys Uncertain significance Single submitter
- TAS2R30 p.Val146Leu Uncertain significance Single submitter
- TAS2R30 p.Val153Ile Uncertain significance Single submitter
- TAS2R30 p.Val249Ala Uncertain significance Single submitter
- TAS2R30 p.Val297Glu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TAS2R30 p.Asn21Lys Uncertain significance Single submitter
- TAS2R30 p.His205Leu Uncertain significance Single submitter
- TAS2R30 p.Leu279Val Uncertain significance Single submitter
- TAS2R30 p.Met209Arg Uncertain significance Single submitter
- TAS2R30 p.Phe118Leu Uncertain significance Single submitter
- TAS2R30 p.Ser248Pro Uncertain significance Single submitter
All TAS2R30 variants
Likely benign 8
- p.Ala52= Single submitter
- p.Arg109Lys Single submitter
- p.Glu34Asp Single submitter
- p.Leu138Val Single submitter
- p.Met104Ile Single submitter
- p.Phe263Leu Single submitter
- p.Ser96Asn Single submitter
- p.Trp154Arg Single submitter
Uncertain significance 40
- p.Ala227Thr Single submitter ⚠
- p.Ala315Thr Single submitter ⚠
- p.Ala52Ser Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg304Lys Single submitter ⚠
- p.Asn112Ser Single submitter ⚠
- p.Asn21Lys Single submitter ⚠
- p.Gly215Arg Single submitter ⚠
- p.His205Leu Single submitter ⚠
- p.His296Tyr Single submitter ⚠
- p.His309Arg Single submitter ⚠
- p.His65Gln Single submitter ⚠
- p.Ile117Val Single submitter ⚠
- p.Ile121Met Single submitter ⚠
- p.Ile16Leu Single submitter ⚠
- p.Ile19Met Single submitter ⚠
- p.Ile225Val Single submitter ⚠
- p.Ile27Met Single submitter ⚠
- p.Leu130Met Single submitter ⚠
- p.Leu182Val Single submitter ⚠
- p.Leu279Val Single submitter ⚠
- p.Lys122Arg Single submitter ⚠
- p.Lys302Thr Single submitter ⚠
- p.Met209Arg Single submitter ⚠
- p.Met262Ile Single submitter ⚠
- p.Met262Leu Single submitter ⚠
- p.Phe118Leu Single submitter ⚠
- p.Phe9Leu Single submitter ⚠
- p.Ser10Phe Single submitter ⚠
- p.Ser248Pro Single submitter ⚠
- p.Ser77Asn Single submitter ⚠
- p.Thr69Ala Single submitter ⚠
- p.Thr83Ser Single submitter ⚠
- p.Trp164Cys Single submitter ⚠
- p.Trp60Leu Single submitter ⚠
- p.Tyr158Cys Single submitter ⚠
- p.Val146Leu Single submitter ⚠
- p.Val153Ile Single submitter ⚠
- p.Val249Ala Single submitter ⚠
- p.Val297Glu Single submitter ⚠