TAS2R41 — 39 ClinVar variants
All ClinVar germline TAS2R41 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Likely benign · 36 Uncertain significance
Full TAS2R41 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R41 p.Ala22Val Uncertain significance Single submitter
- TAS2R41 p.Ala271Thr Uncertain significance Single submitter
- TAS2R41 p.Arg40Ser Uncertain significance Single submitter
- TAS2R41 p.Arg55His Uncertain significance Single submitter
- TAS2R41 p.Asn173Lys Uncertain significance Single submitter
- TAS2R41 p.Asp263Asn Uncertain significance Single submitter
- TAS2R41 p.Gln261Pro Uncertain significance Single submitter
- TAS2R41 p.Gln269Arg Uncertain significance Single submitter
- TAS2R41 p.Gln83Arg Uncertain significance Single submitter
- TAS2R41 p.Gly39Ala Uncertain significance Single submitter
- TAS2R41 p.His219Tyr Uncertain significance Single submitter
- TAS2R41 p.His86Arg Uncertain significance Single submitter
- TAS2R41 p.Ile161Met Uncertain significance Single submitter
- TAS2R41 p.Ile241Ser Uncertain significance Single submitter
- TAS2R41 p.Ile251Leu Uncertain significance Single submitter
- TAS2R41 p.Ile252Thr Uncertain significance Single submitter
- TAS2R41 p.Ile27Thr Uncertain significance Single submitter
- TAS2R41 p.Leu135Val Uncertain significance Single submitter
- TAS2R41 p.Leu19Val Uncertain significance Single submitter
- TAS2R41 p.Leu290Phe Uncertain significance Single submitter
- TAS2R41 p.Lys73Glu Uncertain significance Single submitter
- TAS2R41 p.Phe164Tyr Uncertain significance Single submitter
- TAS2R41 p.Phe285Ile Uncertain significance Single submitter
- TAS2R41 p.Pro192His Uncertain significance Single submitter
- TAS2R41 p.Ser238Tyr Uncertain significance Single submitter
- TAS2R41 p.Ser50Thr Uncertain significance Single submitter
- TAS2R41 p.Ser70Tyr Uncertain significance Single submitter
- TAS2R41 p.Thr145Pro Uncertain significance Single submitter
- TAS2R41 p.Val138Ile Uncertain significance Single submitter
- TAS2R41 p.Val293Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TAS2R41 variants
Likely benign 3
- p.Arg82Gln Single submitter
- p.Thr63Met Single submitter
- p.Val109Met Single submitter
Uncertain significance 36
- p.Ala228Asp Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala271Thr Single submitter ⚠
- p.Arg40Ser Single submitter ⚠
- p.Arg55His Single submitter ⚠
- p.Asn173Lys Single submitter ⚠
- p.Asp263Asn Single submitter ⚠
- p.Gln261Pro Single submitter ⚠
- p.Gln269Arg Single submitter ⚠
- p.Gln83Arg Single submitter ⚠
- p.Gly39Ala Single submitter ⚠
- p.His219Tyr Single submitter ⚠
- p.His86Arg Single submitter ⚠
- p.Ile161Met Single submitter ⚠
- p.Ile241Ser Single submitter ⚠
- p.Ile251Leu Single submitter ⚠
- p.Ile252Thr Single submitter ⚠
- p.Ile27Thr Single submitter ⚠
- p.Leu135Val Single submitter ⚠
- p.Leu19Pro Single submitter ⚠
- p.Leu19Val Single submitter ⚠
- p.Leu290Phe Single submitter ⚠
- p.Lys73Glu Single submitter ⚠
- p.Phe164Tyr Single submitter ⚠
- p.Phe239Leu Single submitter ⚠
- p.Phe285Ile Single submitter ⚠
- p.Pro192His Single submitter ⚠
- p.Ser206Tyr Single submitter ⚠
- p.Ser238Tyr Single submitter ⚠
- p.Ser50Thr Single submitter ⚠
- p.Ser70Tyr Single submitter ⚠
- p.Thr145Pro Single submitter ⚠
- p.Val130Glu Single submitter
- p.Val138Asp Single submitter ⚠
- p.Val138Ile Single submitter ⚠
- p.Val293Met Single submitter ⚠