TAS2R5 — 46 ClinVar variants
All ClinVar germline TAS2R5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
3 Likely benign · 43 Uncertain significance
Full TAS2R5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R5 p.Gly132Ser Uncertain significance Multiple submitters
- TAS2R5 p.Ala207Val Uncertain significance Single submitter
- TAS2R5 p.Ala214Thr Uncertain significance Single submitter
- TAS2R5 p.Ala293Val Uncertain significance Single submitter
- TAS2R5 p.Ala52Val Uncertain significance Single submitter
- TAS2R5 p.Ala91Thr Uncertain significance Single submitter
- TAS2R5 p.Ala96Thr Uncertain significance Single submitter
- TAS2R5 p.Arg112Cys Uncertain significance Single submitter
- TAS2R5 p.Arg159Gln Uncertain significance Single submitter
- TAS2R5 p.Arg210Gly Uncertain significance Single submitter
- TAS2R5 p.Arg213Trp Uncertain significance Single submitter
- TAS2R5 p.Arg76Cys Uncertain significance Single submitter
- TAS2R5 p.Asn124His Uncertain significance Single submitter
- TAS2R5 p.Asn40Thr Uncertain significance Single submitter
- TAS2R5 p.Cys129Gly Uncertain significance Single submitter
- TAS2R5 p.Gly145Arg Uncertain significance Single submitter
- TAS2R5 p.Gly298Ala Uncertain significance Single submitter
- TAS2R5 p.His199Arg Uncertain significance Single submitter
- TAS2R5 p.His199Tyr Uncertain significance Single submitter
- TAS2R5 p.His205Arg Uncertain significance Single submitter
- TAS2R5 p.Ile286Val Uncertain significance Single submitter
- TAS2R5 p.Ile48Phe Uncertain significance Single submitter
- TAS2R5 p.Ile83Thr Uncertain significance Single submitter
- TAS2R5 p.Leu127Arg Uncertain significance Single submitter
- TAS2R5 p.Leu185Phe Uncertain significance Single submitter
- TAS2R5 p.Lys245Glu Uncertain significance Single submitter
- TAS2R5 p.Met190Ile Uncertain significance Single submitter
- TAS2R5 p.Phe110Val Uncertain significance Single submitter
- TAS2R5 p.Phe17Cys Uncertain significance Single submitter
- TAS2R5 p.Pro239Ser Uncertain significance Single submitter
- TAS2R5 p.Ser241Cys Uncertain significance Single submitter
- TAS2R5 p.Ser89Cys Uncertain significance Single submitter
- TAS2R5 p.Trp41Arg Uncertain significance Single submitter
- TAS2R5 p.Tyr264Phe Uncertain significance Single submitter
- TAS2R5 p.Val12Gly Uncertain significance Single submitter
- TAS2R5 p.Val29Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TAS2R5 variants
Likely benign 3
- p.Ala220Val Single submitter
- p.Arg112His Single submitter
- p.Gln166His Single submitter
Uncertain significance 43
- p.Gly132Ser Multiple submitters ⚠
- p.Ala207Val Single submitter ⚠
- p.Ala214Thr Single submitter ⚠
- p.Ala293Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala91Thr Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg112Cys Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg210Gly Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg76Cys Single submitter ⚠
- p.Asn124His Single submitter ⚠
- p.Asn24Ser Single submitter
- p.Asn40Thr Single submitter ⚠
- p.Cys129Gly Single submitter ⚠
- p.Gly145Arg Single submitter ⚠
- p.Gly298Ala Single submitter ⚠
- p.His199Arg Single submitter ⚠
- p.His199Pro Single submitter ⚠
- p.His199Tyr Single submitter ⚠
- p.His205Arg Single submitter ⚠
- p.Ile107Phe Single submitter
- p.Ile286Val Single submitter ⚠
- p.Ile48Phe Single submitter ⚠
- p.Ile83Thr Single submitter ⚠
- p.Leu127Arg Single submitter ⚠
- p.Leu185Phe Single submitter ⚠
- p.Lys245Glu Single submitter ⚠
- p.Met190Ile Single submitter ⚠
- p.Met261Thr Single submitter ⚠
- p.Phe110Val Single submitter ⚠
- p.Phe17Cys Single submitter ⚠
- p.Phe227Cys Single submitter ⚠
- p.Pro239Ser Single submitter ⚠
- p.Pro265Ser Single submitter ⚠
- p.Ser241Cys Single submitter ⚠
- p.Ser67Arg Single submitter ⚠
- p.Ser89Cys Single submitter ⚠
- p.Trp41Arg Single submitter ⚠
- p.Tyr264Phe Single submitter ⚠
- p.Val12Gly Single submitter ⚠
- p.Val29Ala Single submitter ⚠