TAS2R50 — 35 ClinVar variants
All ClinVar germline TAS2R50 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 3 Likely benign · 31 Uncertain significance
Full TAS2R50 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R50 p.Ala147Thr Uncertain significance Single submitter
- TAS2R50 p.Ala28Val Uncertain significance Single submitter
- TAS2R50 p.Arg123Lys Uncertain significance Single submitter
- TAS2R50 p.Arg256Trp Uncertain significance Single submitter
- TAS2R50 p.Arg38Gly Uncertain significance Single submitter
- TAS2R50 p.Cys238Arg Uncertain significance Single submitter
- TAS2R50 p.Glu157Ala Uncertain significance Single submitter
- TAS2R50 p.His205Gln Uncertain significance Single submitter
- TAS2R50 p.His212Arg Uncertain significance Single submitter
- TAS2R50 p.Ile104Val Uncertain significance Single submitter
- TAS2R50 p.Ile186Leu Uncertain significance Single submitter
- TAS2R50 p.Ile56Thr Uncertain significance Single submitter
- TAS2R50 p.Leu71Ser Uncertain significance Single submitter
- TAS2R50 p.Lys287Asn Uncertain significance Single submitter
- TAS2R50 p.Lys39Arg Uncertain significance Single submitter
- TAS2R50 p.Lys40Asn Uncertain significance Single submitter
- TAS2R50 p.Met162Leu Uncertain significance Single submitter
- TAS2R50 p.Met166Ile Uncertain significance Single submitter
- TAS2R50 p.Met262Thr Uncertain significance Single submitter
- TAS2R50 p.Phe242Leu Uncertain significance Single submitter
- TAS2R50 p.Phe277Ile Uncertain significance Single submitter
- TAS2R50 p.Pro259Leu Uncertain significance Single submitter
- TAS2R50 p.Ser114Pro Uncertain significance Single submitter
- TAS2R50 p.Ser264Asn Uncertain significance Single submitter
- TAS2R50 p.Thr283Ile Uncertain significance Single submitter
- TAS2R50 p.Tyr76Cys Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TAS2R50 variants
Benign 1
- p.Leu29= Multiple submitters
Likely benign 3
- p.Ile297Leu Single submitter
- p.Leu177Met Single submitter
- p.Leu272Pro Single submitter
Uncertain significance 31
- p.Ala147Thr Single submitter ⚠
- p.Ala28Val Single submitter ⚠
- p.Arg123Lys Single submitter ⚠
- p.Arg124Gly Single submitter ⚠
- p.Arg256Trp Single submitter ⚠
- p.Arg38Gly Single submitter ⚠
- p.Cys238Arg Single submitter ⚠
- p.Glu157Ala Single submitter ⚠
- p.His205Gln Single submitter ⚠
- p.His212Arg Single submitter ⚠
- p.Ile104Val Single submitter ⚠
- p.Ile110Phe Single submitter ⚠
- p.Ile186Leu Single submitter ⚠
- p.Ile199Asn Single submitter ⚠
- p.Ile56Thr Single submitter ⚠
- p.Leu140Trp Single submitter ⚠
- p.Leu71Ser Single submitter ⚠
- p.Lys287Asn Single submitter ⚠
- p.Lys39Arg Single submitter ⚠
- p.Lys40Asn Single submitter ⚠
- p.Met162Leu Single submitter ⚠
- p.Met166Ile Single submitter ⚠
- p.Met262Thr Single submitter ⚠
- p.Phe242Leu Single submitter ⚠
- p.Phe277Ile Single submitter ⚠
- p.Pro259Leu Single submitter ⚠
- p.Ser114Pro Single submitter ⚠
- p.Ser216Trp Single submitter ⚠
- p.Ser264Asn Single submitter ⚠
- p.Thr283Ile Single submitter ⚠
- p.Tyr76Cys Single submitter ⚠