TAS2R60 — 49 ClinVar variants
All ClinVar germline TAS2R60 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
8 Likely benign · 41 Uncertain significance
Full TAS2R60 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R60 p.Ala123Ser Uncertain significance Single submitter
- TAS2R60 p.Ala245Ser Uncertain significance Single submitter
- TAS2R60 p.Ala248Val Uncertain significance Single submitter
- TAS2R60 p.Ala289Glu Uncertain significance Single submitter
- TAS2R60 p.Ala33Ser Uncertain significance Single submitter
- TAS2R60 p.Arg186Gln Uncertain significance Single submitter
- TAS2R60 p.Arg28His Uncertain significance Single submitter
- TAS2R60 p.Arg311His Uncertain significance Single submitter
- TAS2R60 p.Arg66His Uncertain significance Single submitter
- TAS2R60 p.Asn90Lys Uncertain significance Single submitter
- TAS2R60 p.Asp101Glu Uncertain significance Single submitter
- TAS2R60 p.Asp275Gly Uncertain significance Single submitter
- TAS2R60 p.Gln176Arg Uncertain significance Single submitter
- TAS2R60 p.Gly9Arg Uncertain significance Single submitter
- TAS2R60 p.His164Arg Uncertain significance Single submitter
- TAS2R60 p.Ile257Met Uncertain significance Single submitter
- TAS2R60 p.Ile257Val Uncertain significance Single submitter
- TAS2R60 p.Leu255Phe Uncertain significance Single submitter
- TAS2R60 p.Leu82Trp Uncertain significance Single submitter
- TAS2R60 p.Lys121Gln Uncertain significance Single submitter
- TAS2R60 p.Lys15Arg Uncertain significance Single submitter
- TAS2R60 p.Lys244Arg Uncertain significance Single submitter
- TAS2R60 p.Met144Ile Uncertain significance Single submitter
- TAS2R60 p.Met166Thr Uncertain significance Single submitter
- TAS2R60 p.Met254Leu Uncertain significance Single submitter
- TAS2R60 p.Met6Ile Uncertain significance Single submitter
- TAS2R60 p.Pro142Leu Uncertain significance Single submitter
- TAS2R60 p.Ser10Tyr Uncertain significance Single submitter
- TAS2R60 p.Ser184Gly Uncertain significance Single submitter
- TAS2R60 p.Ser232Ala Uncertain significance Single submitter
- TAS2R60 p.Ser258Pro Uncertain significance Single submitter
- TAS2R60 p.Ser309Thr Uncertain significance Single submitter
- TAS2R60 p.Trp132Ser Uncertain significance Single submitter
- TAS2R60 p.Trp202Gly Uncertain significance Single submitter
- TAS2R60 p.Tyr193Cys Uncertain significance Single submitter
- TAS2R60 p.Val264Leu Uncertain significance Single submitter
- TAS2R60 p.Val280Leu Uncertain significance Single submitter
- TAS2R60 p.Val30Leu Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All TAS2R60 variants
Likely benign 8
- p.Arg186Trp Single submitter
- p.Arg28Cys Single submitter
- p.Arg311Cys Single submitter
- p.Asp183Asn Single submitter
- p.Ile243Val Single submitter
- p.Met85Thr Single submitter
- p.Ser11Leu Single submitter
- p.Thr155Ser Single submitter
Uncertain significance 41
- p.Ala123Ser Single submitter ⚠
- p.Ala245Ser Single submitter ⚠
- p.Ala248Val Single submitter ⚠
- p.Ala289Glu Single submitter ⚠
- p.Ala33Ser Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg28His Single submitter ⚠
- p.Arg311His Single submitter ⚠
- p.Arg49Trp Single submitter ⚠
- p.Arg66His Single submitter ⚠
- p.Asn90Lys Single submitter ⚠
- p.Asp101Glu Single submitter ⚠
- p.Asp275Gly Single submitter ⚠
- p.Gln176Arg Single submitter ⚠
- p.Gly9Arg Single submitter ⚠
- p.His164Arg Single submitter ⚠
- p.Ile257Met Single submitter ⚠
- p.Ile257Val Single submitter ⚠
- p.Leu255Phe Single submitter ⚠
- p.Leu82Trp Single submitter ⚠
- p.Lys121Gln Single submitter ⚠
- p.Lys15Arg Single submitter ⚠
- p.Lys244Arg Single submitter ⚠
- p.Met144Ile Single submitter ⚠
- p.Met166Thr Single submitter ⚠
- p.Met254Leu Single submitter ⚠
- p.Met6Ile Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro196Thr Single submitter ⚠
- p.Pro293Leu Single submitter ⚠
- p.Ser10Tyr Single submitter ⚠
- p.Ser184Gly Single submitter ⚠
- p.Ser232Ala Single submitter ⚠
- p.Ser258Pro Single submitter ⚠
- p.Ser309Thr Single submitter ⚠
- p.Trp132Ser Single submitter ⚠
- p.Trp202Gly Single submitter ⚠
- p.Tyr193Cys Single submitter ⚠
- p.Val264Leu Single submitter ⚠
- p.Val280Leu Single submitter ⚠
- p.Val30Leu Single submitter ⚠