TAS2R7 — 53 ClinVar variants
All ClinVar germline TAS2R7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Benign · 4 Likely benign · 48 Uncertain significance
Full TAS2R7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R7 p.Thr227Ile Uncertain significance Multiple submitters
- TAS2R7 p.Ala52Val Uncertain significance Single submitter
- TAS2R7 p.Arg157Lys Uncertain significance Single submitter
- TAS2R7 p.Arg164Lys Uncertain significance Single submitter
- TAS2R7 p.Arg210Lys Uncertain significance Single submitter
- TAS2R7 p.Asn153Lys Uncertain significance Single submitter
- TAS2R7 p.Asn187Ser Uncertain significance Single submitter
- TAS2R7 p.Asn290His Uncertain significance Single submitter
- TAS2R7 p.Asp224Asn Uncertain significance Single submitter
- TAS2R7 p.Cys137Ser Uncertain significance Single submitter
- TAS2R7 p.Cys172Ser Uncertain significance Single submitter
- TAS2R7 p.Cys66Tyr Uncertain significance Single submitter
- TAS2R7 p.His116Gln Uncertain significance Single submitter
- TAS2R7 p.Ile130Phe Uncertain significance Single submitter
- TAS2R7 p.Ile130Thr Uncertain significance Single submitter
- TAS2R7 p.Ile253Thr Uncertain significance Single submitter
- TAS2R7 p.Ile306Thr Uncertain significance Single submitter
- TAS2R7 p.Ile318Asn Uncertain significance Single submitter
- TAS2R7 p.Ile44Val Uncertain significance Single submitter
- TAS2R7 p.Leu168Phe Uncertain significance Single submitter
- TAS2R7 p.Leu292Ile Uncertain significance Single submitter
- TAS2R7 p.Lys123Arg Uncertain significance Single submitter
- TAS2R7 p.Lys308Asn Uncertain significance Single submitter
- TAS2R7 p.Met33Ile Uncertain significance Single submitter
- TAS2R7 p.Met82Val Uncertain significance Single submitter
- TAS2R7 p.Phe88Leu Uncertain significance Single submitter
- TAS2R7 p.Pro73Thr Uncertain significance Single submitter
- TAS2R7 p.Ser296Tyr Uncertain significance Single submitter
- TAS2R7 p.Thr227Ser Uncertain significance Single submitter
- TAS2R7 p.Val129Leu Uncertain significance Single submitter
- TAS2R7 p.Val160Met Uncertain significance Single submitter
- TAS2R7 p.Val267Met Uncertain significance Single submitter
- TAS2R7 p.Val299Leu Uncertain significance Single submitter
- TAS2R7 p.Val75Leu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- TAS2R7 p.Arg310Gly Uncertain significance Single submitter
- TAS2R7 p.Gly136Glu Uncertain significance Single submitter
- TAS2R7 p.Ile253Asn Uncertain significance Single submitter
- TAS2R7 p.Ile62Thr Uncertain significance Single submitter
- TAS2R7 p.Leu134Gln Uncertain significance Single submitter
- TAS2R7 p.Leu140Pro Uncertain significance Single submitter
- TAS2R7 p.Leu203Pro Uncertain significance Single submitter
- TAS2R7 p.Met82Ile Uncertain significance Single submitter
- TAS2R7 p.Ser145Arg Uncertain significance Single submitter
- TAS2R7 p.Ser257Arg Uncertain significance Single submitter
- TAS2R7 p.Ser280Arg Uncertain significance Single submitter
- TAS2R7 p.Thr101Ile Uncertain significance Single submitter
- TAS2R7 p.Thr7Pro Uncertain significance Single submitter
All TAS2R7 variants
Benign 1
- p.Arg214Ter Multiple submitters
Likely benign 4
- p.Arg209Trp Single submitter
- p.Arg214Gln Single submitter
- p.Met260Ile Single submitter
- p.Val138Met Single submitter
Uncertain significance 48
- p.Thr227Ile Multiple submitters ⚠
- p.Ala52Val Single submitter ⚠
- p.Arg157Lys Single submitter ⚠
- p.Arg164Lys Single submitter ⚠
- p.Arg210Lys Single submitter ⚠
- p.Arg310Gly Single submitter ⚠
- p.Asn153Lys Single submitter ⚠
- p.Asn187Ser Single submitter ⚠
- p.Asn290His Single submitter ⚠
- p.Asp224Asn Single submitter ⚠
- p.Cys137Ser Single submitter ⚠
- p.Cys172Ser Single submitter ⚠
- p.Cys66Tyr Single submitter ⚠
- p.Gly136Glu Single submitter ⚠
- p.His116Gln Single submitter ⚠
- p.Ile130Phe Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile253Asn Single submitter ⚠
- p.Ile253Thr Single submitter ⚠
- p.Ile306Thr Single submitter ⚠
- p.Ile318Asn Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Ile62Thr Single submitter ⚠
- p.Leu134Gln Single submitter ⚠
- p.Leu140Pro Single submitter ⚠
- p.Leu168Phe Single submitter ⚠
- p.Leu203Pro Single submitter ⚠
- p.Leu292Ile Single submitter ⚠
- p.Lys123Arg Single submitter ⚠
- p.Lys308Asn Single submitter ⚠
- p.Met33Ile Single submitter ⚠
- p.Met82Ile Single submitter ⚠
- p.Met82Val Single submitter ⚠
- p.Phe88Leu Single submitter ⚠
- p.Pro73Thr Single submitter ⚠
- p.Ser145Arg Single submitter ⚠
- p.Ser200Tyr Single submitter
- p.Ser257Arg Single submitter ⚠
- p.Ser280Arg Single submitter ⚠
- p.Ser296Tyr Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr227Ser Single submitter ⚠
- p.Thr7Pro Single submitter ⚠
- p.Val129Leu Single submitter ⚠
- p.Val160Met Single submitter ⚠
- p.Val267Met Single submitter ⚠
- p.Val299Leu Single submitter ⚠
- p.Val75Leu Single submitter ⚠