TEAD2 — 51 ClinVar variants
All ClinVar germline TEAD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Benign · 48 Uncertain significance
Full TEAD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TEAD2 p.Ala224Thr Uncertain significance Single submitter
- TEAD2 p.Ala9Val Uncertain significance Single submitter
- TEAD2 p.Arg109Pro Uncertain significance Single submitter
- TEAD2 p.Arg225Gln Uncertain significance Single submitter
- TEAD2 p.Arg295His Uncertain significance Single submitter
- TEAD2 p.Arg439His Uncertain significance Single submitter
- TEAD2 p.Arg5Trp Uncertain significance Single submitter
- TEAD2 p.Asp11Glu Uncertain significance Single submitter
- TEAD2 p.Asp420His Uncertain significance Single submitter
- TEAD2 p.Gln207Glu Uncertain significance Single submitter
- TEAD2 p.Glu204Lys Uncertain significance Single submitter
- TEAD2 p.Glu385Lys Uncertain significance Single submitter
- TEAD2 p.Gly316Ser Uncertain significance Single submitter
- TEAD2 p.Gly37Arg Uncertain significance Single submitter
- TEAD2 p.Gly38Val Uncertain significance Single submitter
- TEAD2 p.His392Asn Uncertain significance Single submitter
- TEAD2 p.Ile145Val Uncertain significance Single submitter
- TEAD2 p.Leu191Ser Uncertain significance Single submitter
- TEAD2 p.Leu303Val Uncertain significance Single submitter
- TEAD2 p.Lys75Asn Uncertain significance Single submitter
- TEAD2 p.Pro175Leu Uncertain significance Single submitter
- TEAD2 p.Pro188Leu Uncertain significance Single submitter
- TEAD2 p.Pro195Leu Uncertain significance Single submitter
- TEAD2 p.Pro243Leu Uncertain significance Single submitter
- TEAD2 p.Pro297Thr Uncertain significance Single submitter
- TEAD2 p.Ser14Asn Uncertain significance Single submitter
- TEAD2 p.Ser210Leu Uncertain significance Single submitter
- TEAD2 p.Ser218Leu Uncertain significance Single submitter
- TEAD2 p.Ser249Thr Uncertain significance Single submitter
- TEAD2 p.Ser435Phe Uncertain significance Single submitter
- TEAD2 p.Ser46Asn Uncertain significance Single submitter
- TEAD2 p.Thr135Ile Uncertain significance Single submitter
- TEAD2 p.Thr17Met Uncertain significance Single submitter
- TEAD2 p.Thr216Pro Uncertain significance Single submitter
- TEAD2 p.Val181Ala Uncertain significance Single submitter
- TEAD2 p.Val235Leu Uncertain significance Single submitter
- TEAD2 p.Val275Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- TEAD2 p.Gln116His Benign Multiple submitters
- TEAD2 p.Ala308Val Uncertain significance Single submitter
- TEAD2 p.Arg225Trp Uncertain significance Single submitter
- TEAD2 p.Arg447Cys Uncertain significance Single submitter
- TEAD2 p.Glu438Lys Uncertain significance Single submitter
- TEAD2 p.Gly372Ser Uncertain significance Single submitter
- TEAD2 p.Ser349Phe Uncertain significance Single submitter
- TEAD2 p.Trp168Cys Uncertain significance Single submitter
- TEAD2 p.Val406Ile Uncertain significance Single submitter
All TEAD2 variants
Benign 3
- p.Gln116His Multiple submitters ⚠
- p.Gly226Ala Multiple submitters
- p.Pro213Ser Multiple submitters
Uncertain significance 48
- p.Ala224Thr Single submitter ⚠
- p.Ala308Val Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg109Pro Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg225Trp Single submitter ⚠
- p.Arg276Trp Single submitter
- p.Arg295His Single submitter ⚠
- p.Arg380Cys Single submitter
- p.Arg439His Single submitter ⚠
- p.Arg447Cys Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asp11Glu Single submitter ⚠
- p.Asp420His Single submitter ⚠
- p.Gln207Glu Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Glu385Lys Single submitter ⚠
- p.Glu438Lys Single submitter ⚠
- p.Gly316Ser Single submitter ⚠
- p.Gly372Ser Single submitter ⚠
- p.Gly37Arg Single submitter ⚠
- p.Gly38Val Single submitter ⚠
- p.His392Asn Single submitter ⚠
- p.Ile145Val Single submitter ⚠
- p.Leu191Ser Single submitter ⚠
- p.Leu303Val Single submitter ⚠
- p.Lys75Asn Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro195Leu Single submitter ⚠
- p.Pro243Leu Single submitter ⚠
- p.Pro297Ser Single submitter
- p.Pro297Thr Single submitter ⚠
- p.Ser14Asn Single submitter ⚠
- p.Ser210Leu Single submitter ⚠
- p.Ser218Leu Single submitter ⚠
- p.Ser249Thr Single submitter ⚠
- p.Ser349Phe Single submitter ⚠
- p.Ser435Phe Single submitter ⚠
- p.Ser46Asn Single submitter ⚠
- p.Thr135Ile Single submitter ⚠
- p.Thr17Met Single submitter ⚠
- p.Thr216Pro Single submitter ⚠
- p.Trp168Cys Single submitter ⚠
- p.Val181Ala Single submitter ⚠
- p.Val235Leu Single submitter ⚠
- p.Val275Ile Single submitter ⚠
- p.Val406Ile Single submitter ⚠