TEX10 — 92 ClinVar variants
All ClinVar germline TEX10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
4 Likely benign · 88 Uncertain significance
Full TEX10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 77
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TEX10 p.Ala112Thr Uncertain significance Single submitter
- TEX10 p.Ala273Thr Uncertain significance Single submitter
- TEX10 p.Ala651Thr Uncertain significance Single submitter
- TEX10 p.Arg178His Uncertain significance Single submitter
- TEX10 p.Arg350Gln Uncertain significance Single submitter
- TEX10 p.Arg550Cys Uncertain significance Single submitter
- TEX10 p.Arg703Gln Uncertain significance Single submitter
- TEX10 p.Arg7Cys Uncertain significance Single submitter
- TEX10 p.Arg7His Uncertain significance Single submitter
- TEX10 p.Arg848Gln Uncertain significance Single submitter
- TEX10 p.Asn415His Uncertain significance Single submitter
- TEX10 p.Asn426Ser Uncertain significance Single submitter
- TEX10 p.Asn480Ser Uncertain significance Single submitter
- TEX10 p.Asn850Asp Uncertain significance Single submitter
- TEX10 p.Asp10His Uncertain significance Single submitter
- TEX10 p.Asp203Asn Uncertain significance Single submitter
- TEX10 p.Asp575Asn Uncertain significance Single submitter
- TEX10 p.Asp677Glu Uncertain significance Single submitter
- TEX10 p.Gln120Arg Uncertain significance Single submitter
- TEX10 p.Gln123His Uncertain significance Single submitter
- TEX10 p.Gln280His Uncertain significance Single submitter
- TEX10 p.Gln511Lys Uncertain significance Single submitter
- TEX10 p.Gln885His Uncertain significance Single submitter
- TEX10 p.Gln8Arg Uncertain significance Single submitter
- TEX10 p.Glu102Asp Uncertain significance Single submitter
- TEX10 p.Glu132Gln Uncertain significance Single submitter
- TEX10 p.Gly286Val Uncertain significance Single submitter
- TEX10 p.Gly345Arg Uncertain significance Single submitter
- TEX10 p.Gly704Glu Uncertain significance Single submitter
- TEX10 p.Gly814Glu Uncertain significance Single submitter
- TEX10 p.Gly853Arg Uncertain significance Single submitter
- TEX10 p.His578Gln Uncertain significance Single submitter
- TEX10 p.His658Arg Uncertain significance Single submitter
- TEX10 p.His876Tyr Uncertain significance Single submitter
- TEX10 p.Ile279Val Uncertain significance Single submitter
- TEX10 p.Ile389Thr Uncertain significance Single submitter
- TEX10 p.Ile460Met Uncertain significance Single submitter
- TEX10 p.Ile492Leu Uncertain significance Single submitter
- TEX10 p.Ile530Leu Uncertain significance Single submitter
- TEX10 p.Ile576Val Uncertain significance Single submitter
- TEX10 p.Ile656Met Uncertain significance Single submitter
- TEX10 p.Ile757Val Uncertain significance Single submitter
- TEX10 p.Ile915Thr Uncertain significance Single submitter
- TEX10 p.Leu44Phe Uncertain significance Single submitter
- TEX10 p.Leu522Ser Uncertain significance Single submitter
- TEX10 p.Leu621Ile Uncertain significance Single submitter
- TEX10 p.Leu649Ser Uncertain significance Single submitter
- TEX10 p.Leu696Val Uncertain significance Single submitter
- TEX10 p.Lys34Arg Uncertain significance Single submitter
- TEX10 p.Lys36Glu Uncertain significance Single submitter
- TEX10 p.Lys419Arg Uncertain significance Single submitter
- TEX10 p.Lys693Glu Uncertain significance Single submitter
- TEX10 p.Met843Val Uncertain significance Single submitter
- TEX10 p.Phe266Leu Uncertain significance Single submitter
- TEX10 p.Pro611Ser Uncertain significance Single submitter
- TEX10 p.Pro922Ser Uncertain significance Single submitter
- TEX10 p.Ser220Phe Uncertain significance Single submitter
- TEX10 p.Ser232Asn Uncertain significance Single submitter
- TEX10 p.Ser397Asn Uncertain significance Single submitter
- TEX10 p.Ser472Cys Uncertain significance Single submitter
- TEX10 p.Ser591Asn Uncertain significance Single submitter
- TEX10 p.Ser648Asn Uncertain significance Single submitter
- TEX10 p.Ser790Gly Uncertain significance Single submitter
- TEX10 p.Ser803Gly Uncertain significance Single submitter
- TEX10 p.Thr29Ala Uncertain significance Single submitter
- TEX10 p.Thr31Ala Uncertain significance Single submitter
- TEX10 p.Thr422Ile Uncertain significance Single submitter
- TEX10 p.Thr499Ile Uncertain significance Single submitter
- TEX10 p.Thr689Ala Uncertain significance Single submitter
- TEX10 p.Thr771Ala Uncertain significance Single submitter
- TEX10 p.Thr810Ile Uncertain significance Single submitter
- TEX10 p.Thr810Ser Uncertain significance Single submitter
- TEX10 p.Thr893Ala Uncertain significance Single submitter
- TEX10 p.Tyr299Cys Uncertain significance Single submitter
- TEX10 p.Val103Met Uncertain significance Single submitter
- TEX10 p.Val291Ile Uncertain significance Single submitter
- TEX10 p.Val736Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- TEX10 p.Asp390Ala Uncertain significance Single submitter
- TEX10 p.Asp784Gly Uncertain significance Single submitter
- TEX10 p.His67Asp Uncertain significance Single submitter
- TEX10 p.Leu210Pro Uncertain significance Single submitter
- TEX10 p.Lys13Asn Uncertain significance Single submitter
- TEX10 p.Lys20Gln Uncertain significance Single submitter
- TEX10 p.Lys82Thr Uncertain significance Single submitter
- TEX10 p.Ser549Pro Uncertain significance Single submitter
All TEX10 variants
Likely benign 4
- p.Ala447= Single submitter
- p.Ala606Thr Single submitter
- p.Ile348Val Single submitter
- p.Phe776Leu Single submitter
Uncertain significance 88
- p.Ala112Thr Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Ala651Thr Single submitter ⚠
- p.Arg178His Single submitter ⚠
- p.Arg350Gln Single submitter ⚠
- p.Arg550Cys Single submitter ⚠
- p.Arg703Gln Single submitter ⚠
- p.Arg7Cys Single submitter ⚠
- p.Arg7His Single submitter ⚠
- p.Arg848Gln Single submitter ⚠
- p.Asn415His Single submitter ⚠
- p.Asn426Ser Single submitter ⚠
- p.Asn480Ser Single submitter ⚠
- p.Asn850Asp Single submitter ⚠
- p.Asp10His Single submitter ⚠
- p.Asp203Asn Single submitter ⚠
- p.Asp390Ala Single submitter ⚠
- p.Asp575Asn Single submitter ⚠
- p.Asp677Glu Single submitter ⚠
- p.Asp784Gly Single submitter ⚠
- p.Gln120Arg Single submitter ⚠
- p.Gln123His Single submitter ⚠
- p.Gln280His Single submitter ⚠
- p.Gln511Lys Single submitter ⚠
- p.Gln869Arg Single submitter
- p.Gln885His Single submitter ⚠
- p.Gln8Arg Single submitter ⚠
- p.Glu102Asp Single submitter ⚠
- p.Glu132Gln Single submitter ⚠
- p.Glu901Gln Single submitter
- p.Gly286Val Single submitter ⚠
- p.Gly345Arg Single submitter ⚠
- p.Gly704Glu Single submitter ⚠
- p.Gly814Glu Single submitter ⚠
- p.Gly853Arg Single submitter ⚠
- p.His578Gln Single submitter ⚠
- p.His658Arg Single submitter ⚠
- p.His67Asp Single submitter ⚠
- p.His876Tyr Single submitter ⚠
- p.Ile279Val Single submitter ⚠
- p.Ile389Thr Single submitter ⚠
- p.Ile460Met Single submitter ⚠
- p.Ile492Leu Single submitter ⚠
- p.Ile530Leu Single submitter ⚠
- p.Ile576Val Single submitter ⚠
- p.Ile656Met Single submitter ⚠
- p.Ile757Val Single submitter ⚠
- p.Ile915Thr Single submitter ⚠
- p.Leu210Pro Single submitter ⚠
- p.Leu44Phe Single submitter ⚠
- p.Leu522Ser Single submitter ⚠
- p.Leu621Ile Single submitter ⚠
- p.Leu649Ser Single submitter ⚠
- p.Leu649Trp Single submitter
- p.Leu696Val Single submitter ⚠
- p.Lys13Asn Single submitter ⚠
- p.Lys20Gln Single submitter ⚠
- p.Lys34Arg Single submitter ⚠
- p.Lys36Glu Single submitter ⚠
- p.Lys419Arg Single submitter ⚠
- p.Lys693Glu Single submitter ⚠
- p.Lys82Thr Single submitter ⚠
- p.Met843Val Single submitter ⚠
- p.Phe266Leu Single submitter ⚠
- p.Pro611Ser Single submitter ⚠
- p.Pro922Ser Single submitter ⚠
- p.Ser220Phe Single submitter ⚠
- p.Ser232Asn Single submitter ⚠
- p.Ser397Asn Single submitter ⚠
- p.Ser472Cys Single submitter ⚠
- p.Ser549Pro Single submitter ⚠
- p.Ser591Asn Single submitter ⚠
- p.Ser648Asn Single submitter ⚠
- p.Ser790Gly Single submitter ⚠
- p.Ser803Gly Single submitter ⚠
- p.Thr29Ala Single submitter ⚠
- p.Thr31Ala Single submitter ⚠
- p.Thr422Ile Single submitter ⚠
- p.Thr499Ile Single submitter ⚠
- p.Thr689Ala Single submitter ⚠
- p.Thr771Ala Single submitter ⚠
- p.Thr810Ile Single submitter ⚠
- p.Thr810Ser Single submitter ⚠
- p.Thr893Ala Single submitter ⚠
- p.Tyr299Cys Single submitter ⚠
- p.Val103Met Single submitter ⚠
- p.Val291Ile Single submitter ⚠
- p.Val736Ile Single submitter ⚠