Sugi Variant

Sugi Variant/TEX11

TEX11 — 127 ClinVar variants

All ClinVar germline TEX11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →

16 Pathogenic · 1 Likely pathogenic · 5 Conflicting · 7 Benign · 2 Benign/Likely benign · 31 Likely benign · 65 Uncertain significance

Full TEX11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 69

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 60

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 4

The independent predictors disagree with each other — read with care.

All TEX11 variants

Pathogenic 16

Likely pathogenic 1

  • p.Asp365fs Single submitter spermatogenic failure, X-linked, 2

Conflicting classifications of pathogenicity 5

Benign 7

Benign/Likely benign 2

Likely benign 31

Uncertain significance 65