TEX264 — 50 ClinVar variants
All ClinVar germline TEX264 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Likely benign · 49 Uncertain significance
Full TEX264 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TEX264 p.Ala127Ser Uncertain significance Multiple submitters
- TEX264 p.Ala208Thr Uncertain significance Single submitter
- TEX264 p.Ala25Thr Uncertain significance Single submitter
- TEX264 p.Arg162Gln Uncertain significance Single submitter
- TEX264 p.Arg186Gln Uncertain significance Single submitter
- TEX264 p.Arg236Gln Uncertain significance Single submitter
- TEX264 p.Arg258His Uncertain significance Single submitter
- TEX264 p.Asn45Ser Uncertain significance Single submitter
- TEX264 p.Glu281Lys Uncertain significance Single submitter
- TEX264 p.Glu35Lys Uncertain significance Single submitter
- TEX264 p.Gly255Ser Uncertain significance Single submitter
- TEX264 p.Gly270Ser Uncertain significance Single submitter
- TEX264 p.Gly8Ala Uncertain significance Single submitter
- TEX264 p.His152Arg Uncertain significance Single submitter
- TEX264 p.Ile10Thr Uncertain significance Single submitter
- TEX264 p.Leu100Pro Uncertain significance Single submitter
- TEX264 p.Leu15Phe Uncertain significance Single submitter
- TEX264 p.Leu302Phe Uncertain significance Single submitter
- TEX264 p.Leu56Ile Uncertain significance Single submitter
- TEX264 p.Leu7Val Uncertain significance Single submitter
- TEX264 p.Met54Thr Uncertain significance Single submitter
- TEX264 p.Phe190Val Uncertain significance Single submitter
- TEX264 p.Pro128Ser Uncertain significance Single submitter
- TEX264 p.Pro245Ala Uncertain significance Single submitter
- TEX264 p.Pro308Ser Uncertain significance Single submitter
- TEX264 p.Pro41Ser Uncertain significance Single submitter
- TEX264 p.Ser124Phe Uncertain significance Single submitter
- TEX264 p.Ser129Thr Uncertain significance Single submitter
- TEX264 p.Ser232Thr Uncertain significance Single submitter
- TEX264 p.Ser235Asn Uncertain significance Single submitter
- TEX264 p.Ser249Gly Uncertain significance Single submitter
- TEX264 p.Ser259Thr Uncertain significance Single submitter
- TEX264 p.Ser2Trp Uncertain significance Single submitter
- TEX264 p.Thr157Ile Uncertain significance Single submitter
- TEX264 p.Thr20Met Uncertain significance Single submitter
- TEX264 p.Thr216Arg Uncertain significance Single submitter
- TEX264 p.Thr220Ala Uncertain significance Single submitter
- TEX264 p.Thr224Met Uncertain significance Single submitter
- TEX264 p.Thr299Ser Uncertain significance Single submitter
- TEX264 p.Trp145Arg Uncertain significance Single submitter
- TEX264 p.Tyr167Cys Uncertain significance Single submitter
- TEX264 p.Tyr191Cys Uncertain significance Single submitter
- TEX264 p.Tyr81Cys Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TEX264 variants
Likely benign 1
- p.Val46Ile Single submitter
Uncertain significance 49
- p.Ala127Ser Multiple submitters ⚠
- p.Ala208Thr Single submitter ⚠
- p.Ala25Thr Single submitter ⚠
- p.Ala78Thr Single submitter
- p.Ala95Ser Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg258His Single submitter ⚠
- p.Asn45Ser Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Glu35Lys Single submitter ⚠
- p.Gly119Asp Single submitter ⚠
- p.Gly255Ser Single submitter ⚠
- p.Gly270Ser Single submitter ⚠
- p.Gly8Ala Single submitter ⚠
- p.His152Arg Single submitter ⚠
- p.Ile10Thr Single submitter ⚠
- p.Leu100Pro Single submitter ⚠
- p.Leu15Phe Single submitter ⚠
- p.Leu302Phe Single submitter ⚠
- p.Leu56Ile Single submitter ⚠
- p.Leu7Val Single submitter ⚠
- p.Met54Thr Single submitter ⚠
- p.Phe190Val Single submitter ⚠
- p.Pro128Ser Single submitter ⚠
- p.Pro245Ala Single submitter ⚠
- p.Pro308Ser Single submitter ⚠
- p.Pro41Ser Single submitter ⚠
- p.Ser124Phe Single submitter ⚠
- p.Ser129Thr Single submitter ⚠
- p.Ser232Thr Single submitter ⚠
- p.Ser235Asn Single submitter ⚠
- p.Ser249Gly Single submitter ⚠
- p.Ser259Thr Single submitter ⚠
- p.Ser2Trp Single submitter ⚠
- p.Ser67Asn Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Thr20Met Single submitter ⚠
- p.Thr216Arg Single submitter ⚠
- p.Thr220Ala Single submitter ⚠
- p.Thr224Met Single submitter ⚠
- p.Thr299Ser Single submitter ⚠
- p.Trp145Arg Single submitter ⚠
- p.Tyr167Cys Single submitter ⚠
- p.Tyr191Cys Single submitter ⚠
- p.Tyr81Cys Single submitter ⚠
- p.Val131Met Single submitter ⚠