TGOLN2 — 49 ClinVar variants
All ClinVar germline TGOLN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
3 Likely benign · 46 Uncertain significance
Full TGOLN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TGOLN2 p.Ala13Val Uncertain significance Single submitter
- TGOLN2 p.Ala22Val Uncertain significance Single submitter
- TGOLN2 p.Ala6Val Uncertain significance Single submitter
- TGOLN2 p.Arg259Pro Uncertain significance Single submitter
- TGOLN2 p.Asn96Ser Uncertain significance Single submitter
- TGOLN2 p.Asp163Asn Uncertain significance Single submitter
- TGOLN2 p.Asp261Asn Uncertain significance Single submitter
- TGOLN2 p.Gln256Pro Uncertain significance Single submitter
- TGOLN2 p.Gly32Val Uncertain significance Single submitter
- TGOLN2 p.His57Gln Uncertain significance Single submitter
- TGOLN2 p.Lys120Glu Uncertain significance Single submitter
- TGOLN2 p.Lys273Arg Uncertain significance Single submitter
- TGOLN2 p.Lys288Glu Uncertain significance Single submitter
- TGOLN2 p.Pro19Ala Uncertain significance Single submitter
- TGOLN2 p.Pro19Leu Uncertain significance Single submitter
- TGOLN2 p.Pro254Ala Uncertain significance Single submitter
- TGOLN2 p.Pro254Arg Uncertain significance Single submitter
- TGOLN2 p.Pro257Leu Uncertain significance Single submitter
- TGOLN2 p.Pro276Arg Uncertain significance Single submitter
- TGOLN2 p.Pro291Ser Uncertain significance Single submitter
- TGOLN2 p.Pro338Leu Uncertain significance Single submitter
- TGOLN2 p.Pro58Leu Uncertain significance Single submitter
- TGOLN2 p.Pro81Ser Uncertain significance Single submitter
- TGOLN2 p.Ser124Asn Uncertain significance Single submitter
- TGOLN2 p.Ser150Ile Uncertain significance Single submitter
- TGOLN2 p.Thr119Ala Uncertain significance Single submitter
- TGOLN2 p.Thr119Pro Uncertain significance Single submitter
- TGOLN2 p.Thr296Ser Uncertain significance Single submitter
- TGOLN2 p.Val312Ile Uncertain significance Single submitter
- TGOLN2 p.Val312Phe Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- TGOLN2 p.Ala393Gly Uncertain significance Single submitter
- TGOLN2 p.Ala397Val Uncertain significance Single submitter
- TGOLN2 p.Arg407Gln Uncertain significance Single submitter
- TGOLN2 p.Gln117Arg Uncertain significance Single submitter
- TGOLN2 p.Gln145His Uncertain significance Single submitter
- TGOLN2 p.Gln75His Uncertain significance Single submitter
- TGOLN2 p.Glu171Lys Uncertain significance Single submitter
- TGOLN2 p.Gly169Val Uncertain significance Single submitter
- TGOLN2 p.Leu399Phe Uncertain significance Single submitter
- TGOLN2 p.Lys97Glu Uncertain significance Single submitter
- TGOLN2 p.Ser382Gly Uncertain significance Single submitter
- TGOLN2 p.Thr109Asn Uncertain significance Single submitter
- TGOLN2 p.Thr119Arg Uncertain significance Single submitter
- TGOLN2 p.Val398Ala Uncertain significance Single submitter
All TGOLN2 variants
Likely benign 3
- c.1309-7C>T Single submitter
- p.Ala22Asp Single submitter
- p.Asn152Ser Single submitter
Uncertain significance 46
- c.*42T>C Single submitter
- c.*51C>G Single submitter
- p.Ala13Val Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala393Gly Single submitter ⚠
- p.Ala397Val Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Arg259Pro Single submitter ⚠
- p.Arg407Gln Single submitter ⚠
- p.Asn96Ser Single submitter ⚠
- p.Asp163Asn Single submitter ⚠
- p.Asp261Asn Single submitter ⚠
- p.Gln117Arg Single submitter ⚠
- p.Gln145His Single submitter ⚠
- p.Gln256Pro Single submitter ⚠
- p.Gln75His Single submitter ⚠
- p.Glu171Lys Single submitter ⚠
- p.Gly169Val Single submitter ⚠
- p.Gly32Val Single submitter ⚠
- p.His57Gln Single submitter ⚠
- p.Leu399Phe Single submitter ⚠
- p.Lys120Glu Single submitter ⚠
- p.Lys273Arg Single submitter ⚠
- p.Lys288Glu Single submitter ⚠
- p.Lys97Glu Single submitter ⚠
- p.Pro19Ala Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Pro254Ala Single submitter ⚠
- p.Pro254Arg Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro276Arg Single submitter ⚠
- p.Pro291Ser Single submitter ⚠
- p.Pro338Leu Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Pro81Ser Single submitter ⚠
- p.Ser124Asn Single submitter ⚠
- p.Ser150Ile Single submitter ⚠
- p.Ser382Gly Single submitter ⚠
- p.Thr109Asn Single submitter ⚠
- p.Thr119Ala Single submitter ⚠
- p.Thr119Arg Single submitter ⚠
- p.Thr119Pro Single submitter ⚠
- p.Thr296Ser Single submitter ⚠
- p.Val312Ile Single submitter ⚠
- p.Val312Phe Single submitter ⚠
- p.Val398Ala Single submitter ⚠