TIMM10 — 8 ClinVar variants
All ClinVar germline TIMM10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full TIMM10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TIMM10 p.Ala6Ser Uncertain significance Single submitter
- TIMM10 p.Arg31Gln Uncertain significance Single submitter
- TIMM10 p.Cys33Arg Uncertain significance Single submitter
- TIMM10 p.Glu47Lys Uncertain significance Single submitter
- TIMM10 p.Leu43Phe Uncertain significance Single submitter
- TIMM10 p.Lys81Arg Uncertain significance Single submitter
- TIMM10 p.Met65Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All TIMM10 variants
Uncertain significance 8
- p.Ala6Ser Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Cys33Arg Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.His62Gln Single submitter ⚠
- p.Leu43Phe Single submitter ⚠
- p.Lys81Arg Single submitter ⚠
- p.Met65Leu Single submitter ⚠